The health status of an individual in adulthood
is proposed to be determined by events occurring in the
prenatal and early postnatal period. A common early life
event proven to have long lasting effects on the developing
fetus is stress, including pain. Exposure of fetal and neonatal
infants to repetitive psychological (e.g., maternal stress)
or physiological (e.g., pain, infection, and noise) stress during
this period is proposed to alter mechanisms involved in
the regulation of stress, immunological maturation, pain
perception, and cognition. Such changes, which persist into
adulthood, may occur via alterations in the development of
the hypothalamic-pituitary-adrenal (HPA) axis. This process
is typically referred to as ‘perinatal programming’. Ontogenic
alterations in the development of the HPA-axis have
been related to a number of adult pathologies such as cardiovascular
disease, type 2 diabetes, asthma, as well as psychopathologies
such as anxiety and depression. Objective:
In this review, the effectiveness of complementary and alternative
medicine (CAM), such as music, dietary supplements,
massage and aromatherapy, in reducing perinatal stress in
mothers and infants is examined. An emphasis is placed on
these therapies as preventative measures which may be of
value to individuals at risk of developing disease profiles associated
with the consequences of adverse perinatal programming.
The widening interest in perinatal programming
and CAM suggests the potential for CAM to become a valuable
tool in offsetting negative adult health outcomes resulting
from perinatal programming associated with adverse
gestational early life environments.