Blends as a strategy towards tailored hydrolytic degradation of poly(ɛ-caprolactone-co-d,l-lactide)–poly(ethylene glycol)–poly(ɛ-caprolactone-co-d,l-lactide) co-polymers

Bramfeldt, Hanna; Sarazin, Pierre; Vermette, Patrick

doi:10.1016/j.polymdegradstab.2008.01.023

Cited by 15 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bramfeldt and colleagues (2008) have recently reported binary blends which were prepared from poly(ε-caprolactone) (PCL), and P(CL-co-D,Llactic acid)-P(ethylene glycol)-P(CL-co-D,L-lactic acid) co-polymers, where the D,L-LA content in the side chains varied from 0 to 70 mol% 14 . Blend discs were fabricated by melt-molding, and the effect of blend composition on hydrolytic degradation was studied.…”

Section: Fig 3: Efv Cumulative Release From Different Drug-loaded Pamentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2017

IJPSR

View full text Add to dashboard Cite

ABSTRACT:The number of medical applications for natural or synthetic biomaterials contin\ues to expand. One particularly interesting development concerns the use of injectable polymeric biomaterials. The forms in which the biomaterials are injected can vary from particulate matter, e.g., microspheres or irregularly shaped particles, to gels and cements that are injected in liquid form and which harden inside the body. Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. The development of using polymer combination have attracted much attention because the biodegradation rate of the copolymer is easily controlled by altering its composition. In this review, the fundamental drug delivery systems from polymer blends including the origins and applications of polymer blend systems and polymer blend therapeutics are highlighted. The PCL microparticledispersed PLGA solution may be a good candidate as an injectable bulking agent. Using PCL-PLGA blend, the porous structure of the polymer blends dependent on the blend ratio under the same conditions other than the ratio. When blending PLGA with PEG, the in vitro release studies showed that the initial burst effect was dependent on the PLGA/PEG blend ratio. Moreover, the release rate increased in direct relation to PEG content. Blending PCL with poly(methacrylate) showed that the greater the poly(methacrylate) content, the less pronounced the burst effect and the more sustained the release effect. The latest developments in polymer blend capable of molecular recognition or directing intracellular delivery are surveyed to illustrate areas of research advancing the frontiers of drug delivery.

show abstract

Section: Fig 3: Efv Cumulative Release From Different Drug-loaded Pamentioning

confidence: 99%

“…Furthermore, all blend samples maintained their initial shape throughout the study. Such materials may be interesting for further investigations for applications in cellular therapy and controlled release 14,15,16 .…”

Section: Fig 3: Efv Cumulative Release From Different Drug-loaded Pamentioning

confidence: 99%

Untitled

2017

IJPSR

View full text Add to dashboard Cite

show abstract

“…However, the inability of a neat biocompatible polymer to fulfill all the demands for tissue engineering scaffolds has led to increased interest in blends and composites amid advantages of more improved and tunable properties (degradation, biocompatibility, thermal, barrier, and mechanical), improved integration with native tissue, and lower cost . Polymer blends offer a simple approach to combine the properties of materials without the added complexity of development of a new copolymer . Blending polymers with different degradation profiles may allow customization of the physical and mechanical properties along with the rate of degradation …”

Section: Introductionmentioning

confidence: 99%

“…Polymer blends offer a simple approach to combine the properties of materials without the added complexity of development of a new copolymer . Blending polymers with different degradation profiles may allow customization of the physical and mechanical properties along with the rate of degradation …”

Section: Introductionmentioning

confidence: 99%

Fabrication of co‐continuous poly(ε‐caprolactone)/polyglycolide blend scaffolds for tissue engineering

Allaf

Rivero

Ivanov

2015

J of Applied Polymer Sci

View full text Add to dashboard Cite

The apparent inability of a single biomaterial to meet all the requirements for tissue engineering scaffolds has led to continual research in novel engineered biomaterials. One method to provide new materials and fine‐tune their properties is via mixing materials. In this study, a biodegradable powder blend of poly(ε‐caprolactone) (PCL), polyglycolide (PGA), and poly(ethylene oxide) (PEO) was prepared and three‐dimensional interconnected porous PCL/PGA scaffolds were fabricated by combining cryomilling and compression molding/polymer leaching techniques. The resultant porous scaffolds exhibited co‐continuous morphologies with ∼50% porosity. Mean pore sizes of 24 and 56 μm were achieved by varying milling time. The scaffolds displayed high mechanical properties and water uptake, in addition to a remarkably fast degradation rate. The results demonstrate the potential of this fabrication approach to obtain PCL/PGA blend scaffolds with interconnected porosity. In general, these results provide significant insight into an approach that will lead to the development of new composites and blends in scaffold manufacturing. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42471.

show abstract

“…Current worldwide market volume for polymer blends and alloys is estimated to be more than 700,000 metric tons/year with an average growth rate of 6 to 7 % [1][2][3][4][5][6]. Polymer blends are mixtures of two or more polymers and/or copolymers in which the minor component contributes at least 2 wt%.…”

Section: Introductionmentioning

confidence: 99%