Bleomycin

Abstract

Bleomycin Flagellate erythema: case reportA 20-year-old woman developed flagellate erythema during therapy with bleomycin [route not stated].The woman underwent fertility-preserving ovarian cancer resection with left oophorectomy. Subsequently, she received 4 cycles of 5-day schedule BEP regimen, which included bleomycin 30000IU on days 1, 8, and 15, etoposide and cisplatin. Four months after the initiation of chemotherapy, she noticed a dark streaked rash affecting her chest and the upper part of the dorsum. Dermatological evaluation showed an extensive violaceous and erythematous excoriated rash with a striking linear configuration and a postinflammatory hyperpigmentation.The woman's lesions resolved completely 6 months after the withdrawal of bleomycin.Author comment: "An additional proposed mechanism for bleomycin-induced flagellate hyperpigmentation includes stimulation of melanocytes by adrenocorticotrophic hormone." Boussios S, et al. Bleomycin-induced flagellate erythema in a patient diagnosed with ovarian yolk sac tumor. Case Reports in Oncological Medicine 2015: 2015. Available from: URL: http://doi.org/10.