Bleomycin-induced flagellate hyperpigmentation: Clinical Image

Sutradhar, Shanta Das; Kar, Sumit; Varma, Sushil Kumar; Madke, Bhusan

doi:10.4103/0971-9903.126263

Cited by 1 publication

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“…Omission of bleomycin from treatment regime with oral prednisolone Sutradhar et al, Sewagram, India, 2014 [11] Ovarian dysgerminoma After first cycle of BEP chemotherapy Treatment details not available Lu et al, Taiwan, 2014 [12] Mixed germ cell tumor of mediastinum…”

Section: On Day Fourteen Of First Cycle Abvd Chemotherapymentioning

confidence: 99%

Flagellate rash: An unusual complication of bleomycin therapy – A case report with brief review of literature

Agrawal

Talwar

Saini

et al. 2017

Indian J Med Paediatr Oncol

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Chemotherapy-induced skin rashes are common toxicities encountered which require careful assessment and evaluation as rashes could be a manifestation of primary malignancy itself and a variety of drugs used in combination further complicate the clinical scenario. Bleomycin is an anticancer antibiotic derived from Streptomyces verticillus and has been commonly used in the treatment of Hodgkin's disease, germ cell tumors and for pleurodesis. There are various dermatological adverse effects of bleomycin which have been previously reported in literature including skin peeling, hyperkeratosis, nail bed changes, Raynaud's phenomenon, and palmoplantar desquamation. Bleomycin-induced skin rashes are seen infrequently now a day due to its declining use in clinical practice. We report here a 29-year-old male with Stage III germ cell tumor who developed widespread flagellate rash after receiving 3 cycles of bleomycin-based chemotherapy which responded to treatment with local steroids and omission of bleomycin from further chemotherapy cycles.

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Section: On Day Fourteen Of First Cycle Abvd Chemotherapymentioning

confidence: 99%