Bleomycin-induced structural chromosomal aberrations in spermatogonia and bone-marrow cells of mice

Buul, Paul P.W. van; Goudzwaard, Johan H.

doi:10.1016/0027-5107(80)90096-2

Cited by 46 publications

(6 citation statements)

References 12 publications

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“…This systemic progression of the drug is the reason why it is important not to treat pregnant and lactating women or infants. Although there is no known mutagenicity, chromosomal anomalies have been observed in the marrow and spermatogonia of mice that received high doses of drug by the systemic route (26). Moreover, a teratogenic effect was shown in mice pregnant for 7–12 days who were receiving intraperitoneal doses of 3–5 U/kg/day.…”

Section: Discussionmentioning

confidence: 99%

Raynaud Phenomenon After Treatment of Verruca Vulgaris of the Sole with Intralesional Injection of Bleomycin

Vanhooteghem

Richert

Brassinne

2001

Pediatric Dermatology

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Intralesional injection of bleomycin (BLM) for the treatment of warts resistant to all conventional therapies is of certain interest because of the drug's low toxicity and its efficacy. However, delayed side effects may appear, particularly Raynaud phenomenon. Accordingly, some precautions must be taken in patients with vascular or collagen diseases and, as a precaution, pregnant or lactating women and infants should not be treated with this drug.

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Section: Discussionmentioning

confidence: 99%

Raynaud Phenomenon After Treatment of Verruca Vulgaris of the Sole with Intralesional Injection of Bleomycin

Vanhooteghem

Richert

Brassinne

2001

Pediatric Dermatology

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“…Then, the association of BLM with different doses of ionizing radiation could be expected. BLM can induce reciprocal translocations in germ cells of mice, and although the frequency is lower than that obtained by ionizing radiations, the kind of multivalent configurations is similar in both cases (van Buul and Gouzdwaard, 1980). Likewise, whereas doses of 60 mg/kg BLM can be associated with 5 Gy of GR, lower doses (20 and 40 mg/kg) are not related (Figures 2 and 3).…”

Section: Discussionmentioning

confidence: 88%

“…2) Is it possible to compare the effects of different agents in order to establish similarities and differences? Attempts to answer this last question have included comparing the effect of chemicals and ionizing radiation (e.g., van Buul and Gouzdwaard, 1980) from a subjective point of view, without any statistical or mathematical evaluation. In order to accurately determine the degree of similarity or difference between the effects of chemicals and ionizing radiations in relation to the induction of reciprocal translocations in germ cells, multivariate analysis methods were used.…”

Section: Introductionmentioning

confidence: 99%

A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells

2000

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The degree of similarity between chemical and physical agents in their capacity to induce reciprocal translocations was analyzed by means of multivariate analysis techniques. The effect of three different doses of gamma rays, four doses of X-rays and different doses of adriamycin, mitomycin C, thio-tepa and bleomycin was analyzed. Data were arranged in a basic matrix by two methods: cluster analysis and ordination. Two main groups were found, one including doses of 9 and 10 Gy and the other including the remaining lower doses of ionizing radiation and the other chemicals. Various subgroups were found within the second group. Accordingly, using presence/absence data there was not a specific pattern of chromosomal damage induction for physical and chemical agents. The increase in the frequencies of reciprocal translocation observed with 9 and 10 Gy was due to an increase in the kind of multivalent configurations. This variability could be dose dependent. Likewise, the similarity observed in the second group between the chemicals and the lower doses of ionizing radiation could also be dose dependent.

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“…The induction of structural chromosomal aberrations by bleomycin was studied in the bone marrow cells and spermatogonia of mice at doses of 10, 20, 40, and 80 mg/kg. Bleomycin induced genetically important reciprocal translocations in stem-cell spermatogonia, as measured with the spermatocyte test, and the response of bone marrow cells to bleomycin was not markedly different from that of spermatogonia [56].…”

Section: Chemotherapymentioning

confidence: 99%

Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and Radiotherapy

Okada

Fujisawa

2019

World J Mens Health

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The survival rates of boys and men with cancer have increased due to advances in cancer treatments; however, maintenance of quality of life, including fertility preservation, remains a major issue. Fertile male patients who receive radiation and/or chemotherapy face temporary, long-term, or permanent gonadal damage, particularly with exposure to alkylating agents and whole-body irradiation, which sometimes induce critical germ cell damage. These cytotoxic treatments have a significant impact on a patient's ability to have their own biological offspring, which is of particular concern to cancer patients of reproductive age. Therefore, various strategies are needed in order to preserve male fertility. Sperm cryopreservation is an effective method for preserving spermatozoa. Advances have also been achieved in pre-pubertal germ cell storage and research to generate differentiated male germ cells from various types of stem cells, including embryonic stem cells, induced pluripotent stem cells, and spermatogonial stem cells. These approaches offer hope to many patients in whom germ cell loss is associated with sterility, but are still experimental and preliminary. This review examines the current understanding of the effects of chemotherapy and radiation on male fertility.

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Bleomycin-induced structural chromosomal aberrations in spermatogonia and bone-marrow cells of mice

Cited by 46 publications

References 12 publications

Raynaud Phenomenon After Treatment of Verruca Vulgaris of the Sole with Intralesional Injection of Bleomycin

Raynaud Phenomenon After Treatment of Verruca Vulgaris of the Sole with Intralesional Injection of Bleomycin

A multivariate approach to the association pattern of reciprocal translocations induced by chemicals and ionizing radiation in mouse germ cells

Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and Radiotherapy

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