Bleomycin Sclerotherapy in Lymphangiomas of Head and Neck: Prospective Study of 8 Cases

Porwal, Prateek Kumar; Dubey, Kailash Prasad; Morey, Amit; Singh, Harshita; Pooja, S.; Bose, Alokendu

doi:10.1007/s12070-017-1243-x

Cited by 15 publications

(6 citation statements)

References 7 publications

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“…The most common drugs used for sclerotherapy are OK‐432 (Picibanil) and bleomycin 35 . Previous studies have shown that the efficacy of OK‐432 and bleomycin in treatment for lymphangiomas is either better than or comparable to that of surgical excision 36–39 . Furthermore, the complication rate of sclerotherapy performed with OK‐432 and bleomycin seems to be lower than that of surgical treatment 11,40 .…”

Section: Discussionmentioning

confidence: 99%

“… 35 Previous studies have shown that the efficacy of OK‐432 and bleomycin in treatment for lymphangiomas is either better than or comparable to that of surgical excision. 36 , 37 , 38 , 39 Furthermore, the complication rate of sclerotherapy performed with OK‐432 and bleomycin seems to be lower than that of surgical treatment. 11 , 40 However, an effective response (shrinkage ≥60%) to sclerotherapy mainly occurs in macrocystic lesions, and the disease recurrence rate is ~9%.…”

Section: Discussionmentioning

confidence: 99%

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Cervical lymphangioma in adults: A report of seven cases and review of the literature

Wang

Yang

Guo

et al. 2022

Laryngoscope Investig Oto

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Background Cervical lymphangioma usually occurs in children and is relatively rare in adults. The purpose of this study was to investigate the characteristics of cervical lymphangiomas in adults. Methods We retrospectively reviewed the medical records and analyzed clinical data obtained from seven adult patients who suffered from cervical lymphangioma from January 2008 to June 2021. Results Five (71.43%) of seven cases were asymptomatic and four (57.14%) lymphangiomas had a maximum diameter ≥ 10 cm. Each cervical lymphangioma was located adjacent to the carotid sheath. All the cervical lymphangiomas were completely surgically excised and were pathologically diagnosed as cystic lymphangioma. After a median 32 months follow‐up period, no recurrence was observed. Conclusion Cervical lymphangiomas from adults are often large asymptomatic masses infiltrating or adjacent to surrounding vital structures which brings many difficulties to the surgery, requiring an experienced surgeon to remove the mass.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cervical lymphangioma in adults: A report of seven cases and review of the literature

Wang

Yang

Guo

et al. 2022

Laryngoscope Investig Oto

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“…The principles and methods of interventional sclerotherapy [ 17 ] (using bleomycin at the recommended dose of 0.5 mg/kg in an aqueous solution of 1.5 mg/mL) were as follows: (1) to prevent the side effects of sclerosing agents in infants, patients were > 6 months old unless symptoms of oppression occurred; (2) individual cysts had to be > 1 cm in diameter; (3) imaging findings should suggest infiltration of the lesion into adjacent critical structures; (4) Patients with cervical lymphatic malformation and patients complicated by infection first had to undergo anti-inflammatory treatment for 3–5 days before a sclerosing agent will be injected into the lesion; (5) For abscess formation complicating cervical lymphatic malformation, ultrasound-guided puncture and drainage was administered to patients followed by a simultaneous injection of a sclerosing agent; (6) cervical lymphatic malformation patients with haemorrhage first had to undergo haemostasis, after which a sclerosing agent was injected into the lesion; and (7) for patients without complications, a sclerosing agent had to be injected into the lesion or they had to undergo follow-up ultrasonography.…”

Section: Methodsmentioning

confidence: 99%

Ultrasonographic diagnosis, classification, and treatment of cervical lymphatic malformation in paediatric patients: a retrospective study

Zhong

Geng

et al. 2020

BMC Pediatr

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Background To explore the imaging features, key diagnostic points, classification, treatment, and prognosis of cervical lymphatic malformation. Methods Overall, 320 patients diagnosed with cervical lymphatic malformation were retrospectively analysed in our hospital between 1 January 2014 and 31 December 2017. Imaging modalities included colour Doppler ultrasound, magnetic resonance imaging, and contrast-enhanced computed tomography. Cervical lymphatic malformations were classified by cyst diameter. Treatments included interventional therapy, surgery, and expectant treatment. Results Cervical lymphatic malformation was identified in 320 of 1192 patients with lymphatic malformation. Four were excluded due to misdiagnosis by ultrasonography. Cervical lymphatic malformation was classified as mixed, macrocystic, and microcystic in 184 (57.5%), 117 (36.56%), and 19 (5.94%) patients, respectively. Sixty-four (20%), ten (3.12%), seven (2.19%), and three (0.94%) patients experienced intracystic haemorrhage, infection, concurrent intracystic haemorrhage and infection, and calcification, respectively. Among 260 (81.25%) patients who underwent interventional sclerotherapy, 163 (50.94%) received it once and 96 (30%) received it two or more times. Twenty-eight (8.75%), five (1.56%), and 27 (8.44%) patients underwent surgical resection, interventional sclerotherapy plus surgery, and expectant management, respectively. Conclusions Ultrasonography is useful for diagnosing definite cervical lymphatic malformation. Interventional therapy is the first choice for children with confirmed cervical lymphatic malformation.

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“…33 The other major complications included abscess in one patient and two patients needing surgical decompression after bleomycin injection for orbital lymphagiomas to improve eyelid position. 39,40 The mean duration of follow-up from the last treatment was 17 months (range -1 month to 7 years). The imaging modality on follow-up was reported only in 817 patients.…”

Section: Outcomementioning

confidence: 99%

Bleomycin for Head and Neck Venolymphatic Malformations: A Systematic Review

Finitsis

Faiz

Linton

et al. 2020

Can. J. Neurol. Sci.

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Background: Venolymphatic malformations are rare benign vascular lesions of the head and neck. Sclerotherapy has become the first-line therapy of these lesions with bleomycin being a sclerosing agent commonly used. Purpose: To perform a systematic review of the published literature to synthesize evidence on the safety and efficacy of bleomycin for the treatment of head and neck venolymphatic malformations. Data sources: A systematic review of the literature (January 1995–May 2019) was performed in PubMed, Embase, and Cochrane Library databases to identify studies on sclerotherapy of venolymphatic malformations of the head and neck. Study selection: A total of 32 studies with participants met the inclusion criteria among which 1121 patients were included in the systematic review. Data analysis: Two reviewers independently screened and extracted data and assessed the risk of bias. The primary outcome was the subjective or objective reduction of lesion size as well as minor and major complications. Data synthesis: The bleomycin/pingyangmycin sclerotherapy achieved subjective or objective lesion size reduction in 96.3% (95% CI 94.1%–98.5%) of patients. Minor complications were observed in 16.2% and major complications in 1.1%. Conclusion: Bleomycin is a highly effective treatment of venolymphatic malformations of the head and neck with a low rate of major adverse events. This study represents an update on the “available” evidence, but only low-to-moderate quality studies were available. Limitations: This study reviewed 32 studies performed in different parts of the world, but there was heterogeneity of the study designs and interventions.

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Bleomycin Sclerotherapy in Lymphangiomas of Head and Neck: Prospective Study of 8 Cases

Cited by 15 publications

References 7 publications

Cervical lymphangioma in adults: A report of seven cases and review of the literature

Cervical lymphangioma in adults: A report of seven cases and review of the literature

Ultrasonographic diagnosis, classification, and treatment of cervical lymphatic malformation in paediatric patients: a retrospective study

Bleomycin for Head and Neck Venolymphatic Malformations: A Systematic Review

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