Blepharitis Preferred Practice Pattern®

Amescua, Guillermo; Akpek, Esen K.; Farid, Marjan; Garcia-Ferrer, Francisco; Lin, Amy; Rhee, Michelle K.; Varu, Divya M; Musch, David C.; Dunn, Steven P.; Mah, Francis S.

doi:10.1016/j.ophtha.2018.10.019

Cited by 91 publications

(97 citation statements)

References 96 publications

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“…Demodex blepharitis is a chronic inflammatory disease caused by demodex infestation, affecting the lid margin and ocular surface, which can lead to serious eye problems ( 1 ). The typical symptoms include eye itching, burning, dryness, irritation, watering, blurry vision, or the sensation of heavy eyelids ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Association Between Demodex Infestation and Ocular Surface Microbiota in Patients With Demodex Blepharitis

Yan

Yao

et al. 2020

Front. Med.

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Purpose: The aim of this study was to compare the ocular microbial communities in humans with and without demodex blepharitis in order to elucidate the relationship between ocular microorganisms and demodex infestation. Methods: Bacterial 16S rRNA genes of conjunctival sac samples from 30 demodex blepharitis patients and 14 healthy controls were sequenced using a pyrosequencing method, and their bacterial community structures were compared by bioinformatics. Results: Bacterial community clustering of conjunctival sac in the demodex blepharitis group were significantly distinct from the healthy control group, with significantly higher relative abundances of Firmicutes and Corynebacterium at the phyla level, as well as higher abundances of Lactobacillus and Bifidobacterium at the genus level. The relative abundance of Staphylococcus epidermidis (0.07–2.27%) was positively correlated with the demodex amount and modified OSDI. The major potential factors contribute to demodex blepharitis were Bacilli, Firmicutes, Cyanobacteria, Lactobacillus and Streptophyta. Conclusions: Patients with demodex blepharitis have varying degrees of bacterial microbiota imbalance in the conjunctival sac. Demodex serving as vectors to transfer both skin and environmental flora might be the potential mechanism. In addition, the number and type of demodex affect the specific ocular surface bacteria, presenting as ocular discomfort and obvious signs of blepharitis.

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Section: Introductionmentioning

confidence: 99%

Association Between Demodex Infestation and Ocular Surface Microbiota in Patients With Demodex Blepharitis

Yan

Yao

et al. 2020

Front. Med.

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“…Współczynniki chorobowości dla niewydolności gruczołów Meiboma (MGD) kształtują się w światowej literaturze na bardzo różnych poziomach [6], ze wskazaniem na częstsze występowanie w populacjach azjatyckich niż kaukaskich. Duża jest także zmienność w definiowaniu choroby oraz w aspekcie wieku w badanych grupach [8]. Pacjenci cierpiący na MGD i zapalenie łojotokowe są statystycznie starsi [9] niż cierpiący na zapalenie gronkowcowe (ze średnią wieku wynoszącą w tej grupie 42 lata), które występuje też częściej u kobiet (80% chorych) [10].…”

Section: Występowanieunclassified

“…Ta dosyć droga procedura nie jest objęta refundacją. Aby osiągnąć długotrwałe efekty, powinna być powtarzana [8]. Choć udowodniono skuteczność IPL w leczeniu teleangiektazji, nie ma wystarczających dowodów skutecznego działania w przypadkach trądziku różowatego [46].…”

Section: Postępowanie Pomocniczeunclassified

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Zapalenie brzegów powiek – wszechstronne spojrzenie na powszechne schorzenie

et al. 2020

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Zapalenie brzegów powiek to rozpowszechniona na całym świecie, częsta, przewlekła choroba zapalna aparatu ochronnego oczu, której szczegółowa epidemiologia jest trudna do ustalenia. Również rola poszczególnych czynników etiologicznych, takich jak kolonizacja nużeńcem, pozostaje niedookreślona. Rozpoznanie opiera się na wszechstronnym badaniu przedmiotowym w połączeniu z dokładnym badaniem okulistycznym, uzupełnionym o ewentualne badania dodatkowe. Terapia jest długotrwała i zwykle nie prowadzi do pełnego wyleczenia, wymaga od pacjentów cierpliwości i systematycznego zaangażowania. Stale poszerzany wachlarz terapeutyczny pozostaje poza refundacją w ramach publicznej opieki zdrowotnej większości krajów.

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“…31 The diagnostic criteria considered for blepharitis comprised the presence of symptoms such as burning, tearing, itching, irritation, photophobia, and ndings like hyperemia and/or telangiectasia of eyelid margin, abnormal deposits at the base of the eyelashes, abnormalities of meibomian ori ces such as capping, pouting, and obliteration. 32 Body temperature was measured immediately before the ophthalmologic assessment with a thermo-scan thermometer.…”

mentioning

confidence: 99%

Ocular surface manifestation of COVID-19 and tear film analysis

Meduri

Oliverio

Mancuso

et al. 2020

Preprint

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Purpose: To evaluate the ocular manifestation in patients hospitalized with coronavirus disease 2019 (COVID-19) and to search for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in tears.Methods: This study was conducted in 29 hospitalized patients who were admitted to the COVID center at the Policlinic Hospital of the University of Messina, Italy.All patients underwent an ophthalmologic assessment comprising a Standardized Patient Evaluation of Eye Dryness (SPEED) questionnaire, anterior segment, and the ocular surface examination of both eyes using a portable slit lamp.The Schirmer I test was performed, and the filter paper strip was used to search for the presence of SARS-CoV-2 on the ocular surface by real-time quantitative polymerase chain reaction (RT-qPCR).Results: A total of 10 patients reported ocular symptoms; in particular, four reported eye burning, three reported foreign body sensation, and three reported tearing. Moreover, seven patients presented conjunctival hyperemia and/or chemosis, eleven patients presented blepharitis signs such as lid margin hyperemia and/or telangiectasia, crusted eyelashes, and meibomian orifices alterations. Tear analysis did not reveal the presence of SARS-CoV-2.Conclusion: Ocular symptoms are common in patients with COVID-19; although, tear analysis did not reveal the presence of SARS-CoV-2.

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Blepharitis Preferred Practice Pattern®

Abstract: for Quality Eye Care without any external financial support. Authors and reviewers of the guidelines are volunteers and do not receive any financial compensation for their contributions to the documents. The guidelines are externally reviewed by experts and stakeholders before publication.

Cited by 91 publications

References 96 publications

Association Between Demodex Infestation and Ocular Surface Microbiota in Patients With Demodex Blepharitis

Association Between Demodex Infestation and Ocular Surface Microbiota in Patients With Demodex Blepharitis

Zapalenie brzegów powiek – wszechstronne spojrzenie na powszechne schorzenie

Ocular surface manifestation of COVID-19 and tear film analysis

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