Blinded Comparative Review of Lubricants Commonly Used for Split-Thickness Skin Graft Harvest

Beckett, Allison R.; Larson, Kaitlin J; Brooks, Ronald M.; Lintner, A; Patterson, Sierra; Roberts, Mike L; Blache, Anna L; Kahn, S.

doi:10.1093/jbcr/irz027

Cited by 1 publication

(1 citation statement)

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“…In the failure to comply with IVR trials, the generic topical drug is not eligible for biowaiver and requires in vivo bioequivalence studies, increasing its final price for consumers [ 32 ]. For this reason, the choice of a proper excipient is of great importance, not only for its clinical implications, but its economic consequence for the pharmaceutical industry [ 33 ]. Further research is also needed to know if the effect is similar in females and males or in patients of different ages.…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Skin Homeostasis Changes after Using Different Types of Excipients in Healthy Individuals

Ordoñez-Toro

Montero‐Vílchez

Muñoz-Baeza

et al. 2022

IJERPH

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Excipients are used as vehicles for topical treatments; however, there are not many studies that evaluate the impact of different excipients themselves. The aim of this research is to assess skin homeostasis changes in healthy individuals after using water/oil (W/O), oil/water (O/W), Beeler base, foam and Vaseline excipients. A within-person randomized trial was conducted that included healthy individuals without previous skin diseases. Skin barrier function parameters, including stratum corneum hydration (SCH), transepidermal water loss (TEWL), pH, temperature, erythema, melanin and elasticity (R0, R2, R5 and R7), were measured on the volar forearm before and after using each excipient. Sixty participants were included in the study, with a mean age of 32 years. After applying w/o excipient erythema decreased by 25 AU, (p < 0.001) and elasticity increased by 6%. After using the o/w excipient, erythema decreased by 39.36 AU (p < 0.001) and SCH increased by 6.85 AU (p = 0.009). When applying the Beeler excipient, erythema decreased by 41.23 AU (p < 0.001) and SCH increased by 15.92 AU (p < 0.001). Foam and Vaseline decreased TEWL and erythema. Excipients have a different impact on skin barrier function. Knowing the effect of excipients on the skin could help to develop new topical treatments and help specialists to choose the best excipient according to the pathology.

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Section: Discussionmentioning

confidence: 99%