Blister roof grafting, cultured melanocytes transplantation and non-cultured epidermal cell suspension transplantation in treating stable vitiligo: A mutual self-control study

Bao, Huaye; Hong, Weisong; Fu, Libi; Wei, Xiaodong; Qian, Guoqing; Xu, Aie

doi:10.3109/09546634.2015.1034068

Cited by 21 publications

(25 citation statements)

References 14 publications

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“…27 A greater percentage of satisfactory responses was observed by Bao et al (2015) when treating patients with segmental and non-segmental vitiligo with melanocyte transplantation. 20 The authors observed 53% of the results with excellent repigmentation and 28% with good repigmentation, with noncultured cell suspension. In their study, the authors also compared three different surgical techniques, treating, in the same session, the lesion area divided into three parts (suction blistering grafting, cultured epidermal cell suspension transplantation, and noncultured cell transplantation).…”

Section: Discussionmentioning

confidence: 96%

“…They concluded that the three methods are safe and efficient and should be chosen according to the size and location of the lesions and available laboratory resources. 20 …”

Section: Discussionmentioning

confidence: 99%

“…Some observed worse responses when compared to those observed in the present study, while others demonstrated more favorable responses. 20,22 Many of these differences still cannot be fully explained due to the complex mechanisms related to the pathogenesis of the vitiligo and to diverse factors that can influence the course and response to different treatments.…”

Section: Discussionmentioning

confidence: 99%

“…The rate considered satisfactory was greater than 50% of repigmentation (sum of the results considered excellent and good), such as that used by researchers. 20 Adverse effects during the procedure, such as pain and discomfort, were observed and registered and, after the procedure, the coloration and aspect of the treated areas were evaluated as compared to the adjacent skin. The occurrence of hyperpigmentation, diffuse hypopigmentation or hypopigmentation on the edges was evaluated.…”

Section: Methodsmentioning

confidence: 99%

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Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Ramos

Ramos³

2017

An. Bras. Dermatol.

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BackgroundVitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases. ObjectivesTo evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo.MethodsCase series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. The maximum follow-up period for some patients was 24 months.ResultsOf the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area.Study limitationsSome limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results. CONCLUSION: Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck.

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Section: Discussionmentioning

confidence: 96%

“…They concluded that the three methods are safe and efficient and should be chosen according to the size and location of the lesions and available laboratory resources. 20 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Ramos

Ramos³

2017

An. Bras. Dermatol.

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“…Patients who underwent suction blister epidermal grafting showed excellent repigmentation results and maintained persistent pigment retention at follow‐up when grafts were applied to the face or lips . Additionally, 92% of patients in the Bao et al study developed satisfactory repigmentation (>50% repigmentation) after 10 days . Li and colleagues used a modified suction blister method in 1100 patients .…”

Section: Discussionmentioning

confidence: 99%

Epidermal skin grafting in vitiligo: a pilot study

Janowska

Dini

Panduri

et al. 2016

International Wound Journal

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Vitiligo is a multifactorial acquired dermatosis characterised by achromic or hypochromic macules and by the absence of functioning melanocytes. Treatment depends on the extent of the affected areas and on disease activity. Surgical techniques have proven to be effective in stable cases but can be time-consuming and, in some cases, aesthetically unsatisfying or painful for the patients. The aim of the study was to assess the clinical safety and effectiveness of a new automatic epidermal skin harvesting device in patients with stable localised vitiligo over a minimum 12-month period. This new system (CELLUTOME™ Epidermal Harvesting System, KCI, an ACELITY Company, San Antonio, TX) is a commercially available epidermal skin harvesting system that can be used without local anaesthesia or other pre-treatments and has been shown to have low rates of donor site morbidity. Epidermal skin grafts can used in patients with acute and hard to heal chronic wounds, burns and stable vitiligo. The use of advanced therapies may improve the quality of life, have cost benefits and accelerate re-pigmentation of patients with vitiligo. In our preliminary study, this system was seen to be a safe and efficacious means of harvesting epidermal micrografts containing melanocytes for use in patients with stable vitiligo unresponsive to standard therapies.

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Efficacy of Transplantation of Combination of Noncultured Dermal and Epidermal Cell Suspension vs Epidermal Cell Suspension Alone in Vitiligo

et al. 2019

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IMPORTANCE Surgical interventions, notably noncultured epidermal suspension (NCES), are the next line of treatment in patients with vitiligo who fail to respond to medical therapy. Noncultured epidermal suspension is usually performed in patients with vitiligo with duration of clinical stability (DS) of 12 months or longer because DS is a vital parameter in determining outcome of NCES. In this pilot study, we planned to assess the efficacy of a novel combination of noncultured epidermal cell suspension and noncultured dermal cell suspension (NCES and NDCS) in patients with vitiligo with shorter DS (3-6 months). OBJECTIVE To compare the efficacy of transplantation of NCES and NDCS vs NCES alone in patients with vitiligo with DS of 3 to 6 months. DESIGN, SETTING, AND PARTICIPANTS A single-center randomized clinical trial including 40 patients with focal, segmental, or generalized vitiligo with DS of 3 to 6 months or more than 12 months was carried out. Based on DS, 2 groups including 20 patients each were recruited (DS in group 1, 3 to 6 months; DS in group 2, more than 12 months). Each group was further randomized into 2 subgroups, A and B. INTERVENTION Patients in subgroups 1A and 2A underwent NCES alone, whereas patients in subgroups 1B and 2B underwent NCES and NDCS. MAIN OUTCOMES AND MEASURES Extent of repigmentation, color match, and pattern of repigmentation at 24 weeks. RESULTS Of the 40 study participants, mean (SD) age was 24.9 (4.0) years and 24 (60%) were women; in group 1 with DS for 3 to 6 months, more than 75% repigmentation at 24 weeks was observed in all 10 patients in subgroup 1B (NCES and NDCS) compared with 3 of 10 patients in subgroup 1A (NCES) (100% vs 30%, P = .003). In group 2 (DS > 12 months), the same was observed in 6 of 10 patients in subgroup 2A and 7 of 10 patients in subgroup 2B (NCES) (60% vs 70%, P > .99). The 2 groups and subgroups did not show any significant differences with respect to color matching and pattern of repigmentation. CONCLUSIONS AND RELEVANCE Combination of NCES and NDCS resulted in excellent response in patients with vitiligo with shorter duration of clinical stability compared with NCES alone. This combination may be used early in the course of stable vitiligo without waiting for a period of 12 months or more since last clinical activity.

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Blister roof grafting, cultured melanocytes transplantation and non-cultured epidermal cell suspension transplantation in treating stable vitiligo: A mutual self-control study

Abstract: All the three methods are safe and effective to treat vitiligo. Future studies with larger groups are warranted to confirm our results.

Cited by 21 publications

References 14 publications

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo

Epidermal skin grafting in vitiligo: a pilot study

Efficacy of Transplantation of Combination of Noncultured Dermal and Epidermal Cell Suspension vs Epidermal Cell Suspension Alone in Vitiligo

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