Blistering dermatosis in a Yucatan minipig

A Brief Review of Infrequent Spontaneous Findings, Peculiar Anatomical Microscopic Features, and Potential Artifacts in Göttingen Minipigs

“…This disease was also described in 2009 (Veronin et al 2009), and the lesion consisted of epidermis separated from the dermis by a predominantly clear space that contained a small amount of cellular debris and necrotic mixed inflammatory cells (Figure 10). The superficial dermis contained a mixed, predominantly mononuclear, inflammatory cell population in and around foci of small arterioles, venules, and capillary vessels (Veronin et al 2009). The disease occurs due to the deposition of immunoglobulin (IgG) autoantibodies directed against major hemidesmosomal antigens (Veronin et al 2009).…”

“…Mirsky and coauthors described a spontaneous bullous pemphigoid in Yucatan minipigs in 2000, although this disease may be slightly different to that described in the minipig. This disease was also described in 2009(Veronin et al 2009, and the lesion consisted of epidermis separated from the dermis by a predominantly clear space that contained a small amount of cellular debris and necrotic mixed inflammatory cells (Figure 10). The superficial dermis contained a mixed, predominantly mononuclear, inflammatory cell population in and around foci of small arterioles, venules, and capillary vessels (Veronin et al 2009).…”

“…The superficial dermis contained a mixed, predominantly mononuclear, inflammatory cell population in and around foci of small arterioles, venules, and capillary vessels (Veronin et al 2009). The disease occurs due to the deposition of immunoglobulin (IgG) autoantibodies directed against major hemidesmosomal antigens (Veronin et al 2009). In the Yucatan minipig, IgG autoantibodies similar to those in humans directed against hemidesmosomes (bullous pemphigoid antigen) have been identified both in the skin and in circulation (Olivry et al 2000).…”