Blisters over burn scars in a child

Pedragosa, R; S, Serrano Ortega; Carol-Murillo, J.; Hernández, Jeddú Cruz; Vidal, José Ernesto

doi:10.1111/j.1365-2133.1986.tb06246.x

Cited by 11 publications

(4 citation statements)

References 14 publications

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“…3 Electron microscopic evaluation of the blisters reveals a discontinuous basement membrane within the roof of the blister and a deficiency of anchoring fibrils within the blistered tissue when compared with surrounding uninjured skin. 4 The discontinuity of the basement membrane at the epidermal-dermal junction is related either to defects in reassembly during healing or a latent breakdown of the basement membrane components.…”

Section: Discussionmentioning

confidence: 99%

Local Tissue Flaps: Definitive Treatment for Chronic Blisters After Chemical Burns

Maguina

Busse

2011

Journal of Burn Care & Research

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Chronic blistering in grafted burn wounds is an infrequently described but severely debilitating complication that can appear after alkali burns and seems to coincide with a delay in initial treatment. Histological studies have concluded that the pathogenesis of chronic subepidermal blister formation in previously grafted burn wounds is related to abnormalities in the basement membrane. Although several reports have described this problem, none have reported adequate treatment for the chronic blistering in previously grafted alkali burns. The authors describe the case of a 30-year-old man in whom caustic soda burns treated with excision and split-thickness skin grafting resulted in chronic subepidermal blistering that failed to improve over the next 2 years. The problem was resolved with full-thickness skin excision and reconstruction with bipedicled fasciocutaneous flaps.

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Section: Discussionmentioning

confidence: 99%

Local Tissue Flaps: Definitive Treatment for Chronic Blisters After Chemical Burns

Maguina

Busse

2011

Journal of Burn Care & Research

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“…[7] Minor traumas such as rubbing or friction is also some other etiologic factors for blistering. [8] In either etiology, graft lysis due to delayed blistering is rarely reported at the transplantation sites of autologous split thickness skin grafts after full take. [7] Likewise, blistering of the skin graft after caustic burn is also rare.…”

Section: Discussionmentioning

confidence: 99%

Recalcitrant Caustic Burn Wound and Definitive Treatment with Medial Plantar Flap

Öksüz

Eren

Sever

et al. 2015

Ulus Travma Acil Cerrahi Derg

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Caustic chemicals cause destruction in tissues even long after the initial exposure. This study reported a case of recurrent graft lysis encountered throughout the treatment of a sodium hydroxide burn. A caustic burn on the ankle of a patient was reconstructed with split thickness skin grafts thrice in a period of four months. The burn site healed uneventfully after each skin grafting. However, weeks after each successful graft take, even though the patient did not experience any trauma at his operated ankle, an eczematous blistering at the skin graft site was observed. Thereafter, skin grafts almost totally sloughed over time even after each successful graft take. Six months after the initial burn and recurrent skin graft lysis, the defect site was reconstructed with medial plantar flap. At the postoperative ninth month follow-up, there was no sign of the blistering or skin loss at the burn area after definitive flap surgery. Recurrent graft lysis, in a few weeks after total skin graft take is an unusual complication for most of the burn cases. Caustic burns may have a deceptively superficial appearance concealing the chemical reactions that further damage the tissue. Therefore, early surgical interventions such as deep debridement and graft surgery should be kept in mind as primary treatment options.

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“…. , was performed, the blisters have been found to be subepidermal (2)(3)(4). Therefore, it has been assumed that the problem lies in the basement membrane zone and/or the superficial subepidermal connective tissue (1).…”

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confidence: 99%

Delayed postburn blisters: an immunohistochemical and ultrastructural study

Bergman¹,

David²,

Ramon³

et al. 1997

J Cutan Pathol

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This study was performed in an attempt to further elucidate the pathogenesis of delayed postburn blistering. Two cases were studied ultrastructurally and immunohistochemically, 1 with blisters on the recipient site of autologous split-thickness skin grafts and the other on the donor site. Ultrastructurally, the basement membrane was on the roof of the blisters in both cases, except for a single small blister in the first case where it was on the dermal floor. In the blister roofs, the basement membrane showed small or marked segments of discontinuity. In the adjacent non-blistered healed skin, the basement membrane was usually continuous, and anchoring fibrils were present. Immunoperoxidase staining on frozen sections, using antibodies to laminin, laminin 5, collagen IV, and collagen VII, showed a mostly continuous linear pattern in the adjacent non-blistered skin, which often became discontinuous near the blisters and markedly discontinuous in the blister roofs. In the blister floors, weakly stained linear or granular deposits of some of these components were sometimes also present. The results of this study support discontinuity of the basement membrane as the main anomaly in delayed postburn blistering. Disturbance in the reassembly or local breakdown of the basement membrane components might be the underlying defect.

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Blisters over burn scars in a child

Cited by 11 publications

References 14 publications

Local Tissue Flaps: Definitive Treatment for Chronic Blisters After Chemical Burns

Local Tissue Flaps: Definitive Treatment for Chronic Blisters After Chemical Burns

Recalcitrant Caustic Burn Wound and Definitive Treatment with Medial Plantar Flap

Delayed postburn blisters: an immunohistochemical and ultrastructural study

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