Block copolymer and organic salts in forming aqueous biphases: a platform to identify molecular interactions in aqueous medium

Abstract

An aqueous solution of a tri-block copolymer PPG–PEG–PPG has been used with two organic salts, sodium acetate and sodium citrate, to create new aqueous biphasic systems (ABS).

Using Ionic Liquids To Tune the Performance of Aqueous Biphasic Systems Based on Pluronic L-35 for the Purification of Naringin and Rutin

“…11−16 Scarcer are the studies evaluating the possibility of creating ABS composed of Pluronics and other polymers (e.g., dextran). 17,18 Foreseeing their future application, some authors unveiled the extraction aptitude of Pluronic-based ABS for metallic ions, 19,20 peptides/proteins, 12,13,17 and vitamins, 15 as well as their use for the extractive transformation of steroids. 21 Liu et al 22 reported the combined use of copolymers and cholinium-based ILs, focusing on the liquid−liquid equilibrium data and the impact of the copolymer nature on the ABS formation.…”

“…The use of (EO) x -(PO) y -(EO) x copolymers in ABS is not new, and their combination with conventional salts to induce liquid–liquid demixing in aqueous solution is well documented. Their phase separation phenomena were systematically studied considering distinct salts and Pluronics (varying both the molecular weight and EO/PO ratios) at distinct temperatures and pH. − Scarcer are the studies evaluating the possibility of creating ABS composed of Pluronics and other polymers (e.g., dextran). , Foreseeing their future application, some authors unveiled the extraction aptitude of Pluronic-based ABS for metallic ions, , peptides/proteins, ,, and vitamins, as well as their use for the extractive transformation of steroids . Liu et al reported the combined use of copolymers and cholinium-based ILs, focusing on the liquid–liquid equilibrium data and the impact of the copolymer nature on the ABS formation.…”

Comparison of Salt Cations in the Design of Nonionic Surfactant Based Aqueous Biphasic Systems: Application in Polyphenol Separations

“…The tie-line data were fitted to Othmer-Tobias and Bancroft equations, eqs and ): where W 1 t is the mass fraction of Brij 35 in the top phase; W 2 b is the mass fraction of the salt in the bottom phase; W 3 b and W 3 t are the mass fractions of water in the bottom and the top phases, respectively. K 1 , n , k 2 , and r are the fitting parameters.…”

“…Aqueous biphasic systems mainly comprise water as the solvent and have low interfacial tension, providing a mild and promising biocompatible environment for the efficient extraction and purification of metal species, drugs, and organic biomolecules. − Moreover lower cost, nontoxicity, and the possibility of large scale application make aqueous biphasic extraction systems handier over conventional extraction methods. ABSs are formed by mixing certain aqueous solutions of two hydrophilic polymers or a combination of a polymer with a salt or surfactant with a salt above a definite critical concentration. In recent days, ionic liquids are also involved in designing new ABSs. , …”

“…2−4 Moreover lower cost, nontoxicity, and the possibility of large scale application make aqueous biphasic extraction systems handier over conventional extraction methods. ABSs are formed by mixing certain aqueous solutions of two hydrophilic polymers 5 or a combination of a polymer with a salt 6 or surfactant with a salt 7 above a definite critical concentration. In recent days, ionic liquids are also involved in designing new ABSs.…”