Blockade by burimamide of the effects of histamine and histamine analogues on cardiac adenylate cyclase

Verma, S. C.; McNeill, John H.

doi:10.1111/j.2042-7158.1974.tb09295.x

Cited by 19 publications

(9 citation statements)

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“…accepted since the introduction by BLACK et al [12] of the specific Hz-receptor antagonists. H~-receptors have been classified as mepyramine sensitive, and H2-receptors and burimamide, metiamide and cimetidine sensitive [6][7][8][9][10][11][12][13][14][15]. Species-variation has been reported with respect to histamine responses in heart and blood vessels [16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…Histamine, a highly active biogenic amine, is known to produce a variety of actions such as vasodilatation, increase in capillary permeability, positive inotropic and chronotropic action on guinea pig heart and gastric acid secretion [1][2][3][4][5][6]. It produces contraction in various smooth muscles, such as bronchioles, ileum and spleen [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological investigations into the effects of histamine and histamine analogs on guinea pig and rat uterus

Goyal

Verma

1981

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The effects of histamine and its analogs 2-(2-pyridyl) ethylamine (PEA) and 4-methylhistamine (4 MH) have been studied on uterine preparations obtained from estrogen-primed guinea pigs and rats. (1) Histamine and 4 MH, a specific H2-receptor agonist produced relaxation in estrogen-primed rat uterus, whereas these agonists produced contraction in the estrogen-primed guinea pig uterus. (2) PEA, a specific H1-receptor agonist produced contraction in the guinea pig uterus but had no effect on the rat uterus. (3) Metiamide blocked responses to histamine and 4 MH in the rat uterus, whereas mepyramine blocked responses to histamine and PEA in the guinea pig uterus. (4) Propranolol produced competitive antagonism with histamine in the rat uterus, whereas it had no significant effect on the histamine or PEA responses in the guinea pig uterus. (5) Reserpine pretreatment completely abolished the responses to histamine and 4 MH in the rat uterus but did not alter the response in the guinea pig uterus. (6) Our data suggest that in rat uterus only H2-receptors are present and they are indirectly through the release of noradrenaline. In the guinea pig uterus both H1- and H2-receptors are present and are excitatory and directly acting.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacological investigations into the effects of histamine and histamine analogs on guinea pig and rat uterus

Goyal

Verma

1981

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“…Tolazoline produced vasodilation, which is suggested to be due to H~-receptor stimulation [21] and also produced gastric acid secretion and tachycardia, these latter effects have been classified as HE-histaminergic effects [8,[22][23][24]. Previous work from our laboratory has suggested that the positive inotropic effect of histamine is indeed due to H Ereceptor stimulation in the isolated perfused guinea pig heart [8,9,25]. Other data, however, suggest that the inotropic effect of histamine is due to Hi-receptor stimulation and the chronotropic effects are due to the H2-receptor stimulation [15,16].…”

Section: Discussionmentioning

confidence: 97%

Investigations into the cardiac effects of tolazoline in guinea pig atria and ventricular strips

Verma

McNeill

1977

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The positive inotropic, chronotropic and cyclic AMP producing effects of tolazoline were studied on atrial and ventricular preparations obtained from guinea pig heart. (1) The direct positive inotropic effects of tolazoline on the paced left atrial preparation from the guinea pig hearts was blocked by promethazine, but not by burimamide. Tolazoline did not elevate cyclic AMP levels in this preparation. (2) Tolazoline produced a positive chronotropic effect which was blocked by burimamide and not by promethazine and caused a 2-3 fold elevation of cyclic AMP in spontaneously beating right atria. (3) Burimamide antagonized the inotropic and cyclic AMP increasing effects of tolazoline on electrically driven ventricular strips. (4) The effects of tolazoline were unchanged by reserpine pretreatment of the guinea pigs or by prior exposure to phentolamine or propranolol. (5) These results suggest that tolazoline can activate both H1 and H2 receptors in the guinea pig heart. Furthermore the data suggests that H2 receptors are present in right atria and ventricle and that such receptors are associated with cyclic AMP. H1 receptors are present in the left atria and are not associated with the cyclic nucleotide.

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“…In the heart, a number of early studies demonstrated that histamine stimulates adenylate cyclase in broken cell preparations of cardiac muscle (Klein & Levey, 1971), by means of an H2-response, since burimamide caused a parallel shift in the histamine dose-response curve, suggesting a competitive inhibition (Verma & McNeill, 1974).…”

Section: Concentration Of Drugs (M)mentioning

confidence: 99%

The antianaphylactic action of histamine H₂‐receptor agonists in the guinea‐pig isolated heart

Blandina

Brunelleschi

Fantozzi

et al. 1987

British J Pharmacology

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1 The effects of histamine and of H,-and H2-receptor agonists on the response to specific antigen were studied in isolated hearts taken from actively sensitized guinea-pigs. 2 Histamine and H2-receptor agonists (dimaprit, impromidine) dose-dependently decrease the positive chronotropic and inotropic effects, and the severity of arrhythmias evoked by the challenge of sensitized hearts with specific antigen. 3 Nordimaprit and the selective H,-receptor agonist 2-pyridyl-ethyl-amine (2-PEA) did not modify the patterns of cardiac anaphylaxis. 4 The positive inotropic and chronotropic responses of the isolated heart to exogenous histamine appear to be partly reduced in the presence of dimaprit. 5 The H2-receptor agonists decrease the amount of histamine released during cardiac anaphylaxis which is increased by cimetidine, while nordimaprit and PEA were ineffective, indicating an inhibitory function afforded by H2-receptors in cardiac anaphylaxis.

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Blockade by burimamide of the effects of histamine and histamine analogues on cardiac adenylate cyclase

Cited by 19 publications

References 5 publications

Pharmacological investigations into the effects of histamine and histamine analogs on guinea pig and rat uterus

Pharmacological investigations into the effects of histamine and histamine analogs on guinea pig and rat uterus

Investigations into the cardiac effects of tolazoline in guinea pig atria and ventricular strips

The antianaphylactic action of histamine H₂‐receptor agonists in the guinea‐pig isolated heart

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Blockade by burimamide of the effects of histamine and histamine analogues on cardiac adenylate cyclase

Cited by 19 publications

References 5 publications

Pharmacological investigations into the effects of histamine and histamine analogs on guinea pig and rat uterus

Pharmacological investigations into the effects of histamine and histamine analogs on guinea pig and rat uterus

Investigations into the cardiac effects of tolazoline in guinea pig atria and ventricular strips

The antianaphylactic action of histamine H2‐receptor agonists in the guinea‐pig isolated heart

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The antianaphylactic action of histamine H₂‐receptor agonists in the guinea‐pig isolated heart