Blockade of a novel MAP4K4-LATS2-SASH1-YAP1 cascade inhibits tumorigenesis and metastasis in luminal breast cancer

Yang, Pingping; Li, Yadong; Hou, Jing; Wu, Daoqiu; Zeng, Xing; Zeng, Zhen; Zhang, Jing; Xiong, Yu; Chen, Lian; Yang, Dan; Wan, Xin; Wu, Zhixiong; Jia, Lei; Liu, Qianfan; Lu, Qingxiang; Zou, Xue; Fang, Wen; Zeng, Xiaohua; Zhou, Ding’an

doi:10.1016/j.jbc.2024.107309

Journal of Biological Chemistry

2024

DOI: 10.1016/j.jbc.2024.107309

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Blockade of a novel MAP4K4-LATS2-SASH1-YAP1 cascade inhibits tumorigenesis and metastasis in luminal breast cancer

Pingping Yang,

Yadong Li,

Jing Hou

et al.

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2024

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Hsp70 incompletely disaggregates the misfolding K488X-menin, promoting the tumorigenesis in a multiple endocrine neoplasia type 1 family

Zeng,

Zhang,

Liang

et al. 2024

Preprint

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Previous standpoints involved into the nonsense mutations and missense variants which caused truncated inactive menin protein of Multiple Endocrine Neoplasia Type 1(MEN1) gene, including loss of heterozygosity(LOH) and menin mutants degradation, cannot wholly interpret MEN1 pathogenesis. A c.1462A > T (p.K488X) mutation in exon10 of MEN1 was identified as the potential pathogenic mutation in an extended Chinese MEN1 family in this study. Ubiquitination modification degradation of K488X-menin result from the combined actions of carboxy-terminus of Hsc70-interacting protein (CHIP) and Hsp70 in vitro. K488X‒menin is a misfolding truncated protein that results in amyloid aggregation state in live cells or the affected tissues, the aggregation of which is promoted by Hsp70 and CHIP. Although Hsp70 disaggregate the aggregated of K488X-menin in vitro, the Hsp70 which is not upregulated in the MEN1 patients’ affected tissue can not completely disaggregate the aggregated K488X, which becomes a toxic intermediate to trigger development process of early tumorigenesis verified in the mutant zebrafish model and the affected tissues to cause the tumorigenic phenotypes in this MEN1 case. Our findings provide a complete novel interpretation to the mechanism of MEN1 tumorigenesis.

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Hsp70 incompletely disaggregates the misfolding K488X-menin, promoting the tumorigenesis in a multiple endocrine neoplasia type 1 family

Zeng,

Zhang,

Liang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Blockade of a novel MAP4K4-LATS2-SASH1-YAP1 cascade inhibits tumorigenesis and metastasis in luminal breast cancer

Cited by 1 publication

References 55 publications

Hsp70 incompletely disaggregates the misfolding K488X-menin, promoting the tumorigenesis in a multiple endocrine neoplasia type 1 family

Hsp70 incompletely disaggregates the misfolding K488X-menin, promoting the tumorigenesis in a multiple endocrine neoplasia type 1 family

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