Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats

Bialy, Michał; Nikolaev-Diak, Anna; Kalata, Urszula; Nikolaev, Evgeni

doi:10.1016/j.physbeh.2011.02.003

Cited by 21 publications

(10 citation statements)

References 45 publications

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“…Chemosignals from estrous females activate the MeA in male hamsters, as seen by Fos expression [4] . Androgen receptors are found in the MeA, and testosterone or dihydrotestosterone are required for NCE stimulated by an estrous female [5] and blocking of androgen receptors in the MeA prevents NCE [6] . Administration of androgens directly into the posterodorsal subnucleus of the medial amygdala (MePD) does not cause spontaneous erection, without the presence of an estrous female [7] therefore, the MePD may be responsible for causing erections when activated by olfactory cues or chemosignals.…”

Section: Introductionmentioning

confidence: 99%

Kisspeptin in the medial amygdala and sexual behavior in male rats

Gresham

Adekunbi

et al. 2016

Neuroscience Letters

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Section: Introductionmentioning

confidence: 99%

Kisspeptin in the medial amygdala and sexual behavior in male rats

Gresham

Adekunbi

et al. 2016

Neuroscience Letters

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“…Testosterone is required for sexual dimorphism of the MeA neurons [8] and also for AVP expression in the MeA [12,13]. The essential nature of testosterone is further supported by the observations that antagonism of androgen receptors in the MeA inhibits penile erection in male rats in presence of estrus females [14]; an effect reversed by testosterone implants within the MeA of castrates [15,16]. …”

Section: Introductionmentioning

confidence: 99%

Copulation or sensory cues from the female augment Fos expression in arginine vasopressin neurons of the posterodorsal medial amygdala of male rats

Dass

Vyas

2014

Front Zool

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BackgroundThe posterodorsal part of the medial amygdala is essential for processing reproductively salient sensory information in rodents. This is the initial brain structure where information from olfactory system and male hormones intersect. The neurochemical identity of the neurons participating in the sensory processing in medial amygdala remains presently undetermined. Many neurons in this brain structure express arginine vasopressin in a testosterone-dependent manner, suggesting that this neuropeptide is maintained by the androgenic milieu.MethodHere we use Fos, a protein expressed by recently active neurons, to quantify activation of arginine vasopressin neurons after exposure to odor from physically inaccessible female. We compare it to mating with accessible female and to reproductively innocuous odor.ResultsWe show that inaccessible female activate arginine vasopressin neurons in the male posterodorsal medial amygdala. The magnitude of activation is not further enhanced when physical access with resultant mating is granted, even though it remains undetermined if same population of AVP neurons is activated by both inaccessible female and copulation. We also show that arginine vasopressin activation cannot be fully accounted for by mere increase in the number of Fos and AVP neurons.ConclusionThese observations posit a role for the medial amygdala arginine vasopressin in reproductive behaviors, suggesting that these neurons serve as integrative node between the hormonal status of the animal and the availability of reproductive opportunities.

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“…Such males displayed longer latencies before their first sexual comportment and had less noncontact erections. Furthermore, they spent less total time in genital grooming in comparison to the control group (Bialy et al, 2011).…”

Section: Pre-copulatory Behaviormentioning

confidence: 81%

Role of the androgen receptor in the central nervous system

Mhaouty-Kodja

2018

Molecular and Cellular Endocrinology

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The involvement of gonadal androgens in functions of the central nervous system was suggested for the first time about half a century ago. Since then, the number of functions attributed to androgens has steadily increased, ranging from regulation of the hypothalamic-pituitary-gonadal axis and reproductive behaviors to modulation of cognition, anxiety and other non-reproductive functions. This review focuses on the implication of the neural androgen receptor in these androgen-sensitive functions and behaviors.

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Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats

Cited by 21 publications

References 45 publications

Kisspeptin in the medial amygdala and sexual behavior in male rats

Kisspeptin in the medial amygdala and sexual behavior in male rats

Copulation or sensory cues from the female augment Fos expression in arginine vasopressin neurons of the posterodorsal medial amygdala of male rats

Role of the androgen receptor in the central nervous system

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