Blockade of central kappa-opioid receptors inhibits the antidipsogenic effect of interleukin-1β

Luz, P. A. C.; Saraiva, Raquel Moreira; Almeida, Tarcísio S.; Fregoneze, J.B.; Silva, E. De Castro e

doi:10.1016/j.npep.2008.12.006

Cited by 7 publications

(1 citation statement)

References 42 publications

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“…This is not surprising given the several mediators activated by LPS. Recall, however, that icv injection of interleukin-1β inhibits all types of thirst [32]. Moreover, LPS given systemically also inhibits thirst induced by icv injections of either angiotensin II or hypertonic NaCl [15].…”

Section: Discussionmentioning

confidence: 99%

Lipopolysaccharide reduces sodium intake and sodium excretion in dehydrated rats

Almeida

Constancio

Vendramini

et al. 2011

Physiology & Behavior

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The objective of this study was to find out if lipopolysaccharide (LPS) administered intraperitoneally affects sodium and water intake and renal excretion in dehydrated rats. LPS (0.3-5 mg/kg b.w.) inhibited 0.3M NaCl intake induced by subcutaneous injection of the diuretic furosemide (FURO, 10 mg/kg b.w.) combined with the angiotensin converting enzyme inhibitor, captopril (CAP, 5 mg/kg b.w.). Only the highest doses of LPS (2.5 and 5 mg/kg) inhibited water intake induced by FURO/CAP. LPS (0.6 mg/kg) reduced urinary volume and sodium excretion, but had no effect on mean arterial pressure or heart rate of rats treated with FURO/CAP. LPS (0.3-5.0 mg/kg) abolished intracellular thirst and reduced by 50% the urine sodium concentration of rats that received 2 ml of 2M NaCl by gavage. LPS (0.3-5.0 mg/kg) also reduced thirst in rats treated with FURO alone (10 mg/rat sc). The results suggest that LPS has a preferential, but not exclusive, inhibitory effect on sodium intake and on intracellular thirst. The inhibition of hydro-mineral intake and the antinatriuresis caused by LPS in dehydrated rats may contribute to the multiple effects of the endotoxin on fluid and electrolyte balance and be part of the strategy to cope with infections.

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Section: Discussionmentioning

confidence: 99%