Blockade of extracellular high-mobility group box 1 attenuates inflammation-mediated damage and haze grade in mice with corneal wounds

Zhou, Yongying; Wang, Ting; Wang, Yuchuan; Meng, Fanlan; Mao, Ying; Han, Ruifang; Peng, Hao; Wang, Liming; Li, Xuan

doi:10.1016/j.intimp.2020.106468

Cited by 24 publications

(20 citation statements)

References 28 publications

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“…These abnormal cells and their immediate neighbors release H 2 O 2 pulses that appear to draw innate immune cells to them; this is a necessary attractant, demonstrated by the finding that blocking Duox in zebrafish larval tissues prevents immune cells from homing to growing clones of precancer cells (52). Other damage attractants, including high mobility group box 1 (HMGB1), appear also to draw leukocytes to both acute wounds and to cancer cells (60)(61)(62), and studies in zebrafish have shown that various chemokines, including those binding to the receptor CXCR2, act as attractants for neutrophils to wounds and also to clones of preneoplastic cancer cells (51,63). Despite having the capacity to engulf and kill preneoplastic cells, innate immune cells are often instead subverted into nurturing them, as indicated by genetic knockdown studies wherein the depletion of leukocytes prevents further preneoplastic growth (51,52,64).…”

Section: Hallmark 3: Tumor-and Repair-promoting Inflammationmentioning

confidence: 99%

The hallmarks of cancer are also the hallmarks of wound healing

2020

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The Hanahan and Weinberg “hallmarks of cancer” papers provide a useful structure for considering the various mechanisms driving cancer progression, and the same might be useful for wound healing. In this Review, we highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer. From sustained proliferative signaling and the activation of invasion and angiogenesis to the promoting role of inflammation, there are many obvious parallels through which one process can inform the other. For some hallmarks, the parallels are more obscure. We propose some new prospective hallmarks that might apply to both cancer and wound healing and discuss how wounding, as in biopsy and surgery, might positively or negatively influence cancer in the clinic.

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Section: Hallmark 3: Tumor-and Repair-promoting Inflammationmentioning

confidence: 99%

The hallmarks of cancer are also the hallmarks of wound healing

2020

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“…When GLY at both acidic and neutral pH, was applied to the scarified normal, uninfected cornea, delayed wound closure was observed at 6 h, but not at 24 h, when compared to PBS. In contrast, in diabetic corneas that received a 2-mm trephine wound, GLY promoted regeneration of the corneal epithelium (Hou et al, 2021b), and closure was observed at 24 h vs. control (Zhou et al, 2020;Hou et al, 2021b). In the skin, licorice containing creams are commonly used to treat wounds (Mostafa et al, 2004, Ciganovićet al, 2019.…”

Section: Discussionmentioning

confidence: 99%

Ocular Effects of Glycyrrhizin at Acidic and Neutral pH

Somayajulu

McClellan

Bessert

et al. 2022

Front. Cell. Infect. Microbiol.

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PurposeTo test the effects of acidic vs. neutral pH glycyrrhizin (GLY) on the unwounded and wounded normal mouse cornea and after infection with Pseudomonas aeruginosa isolates KEI 1025 and multidrug-resistant MDR9.MethodsAcidic or neutral GLY vs. phosphate-buffered saline (PBS) was topically applied to normal or wounded corneas of C57BL/6 mice. In unwounded corneas, goblet cells and corneal nerves were stained and quantitated. After wounding, corneas were fluorescein stained and photographed using a slit lamp. Mice also were infected with KEI 1025 or MDR9 and the protective effects of GLY pH evaluated comparatively.ResultsIn the unwounded cornea, application of acidic or neutral GLY vs. PBS reduced the number of bulbar conjunctival goblet cells but did not alter corneal nerve density. Similar application of GLY to scarified corneas delayed wound closure. After KEI 1025 infection, none of the GLY vs. PBS-treated corneas perforated; GLY treatment also decreased plate count (neutral pH more effective) and reduced MPO and several cytokines. Similarly, for MDR9, GLY at either pH was protective and also enhanced the effects of moxifloxacin to which MDR9 is resistant.ConclusionAcidic or neutral pH GLY decreased goblet cell number but had no effect on nerve density. After corneal wounding, GLY at either pH (1) delayed wound closure and, (2) after infection, decreased keratitis when used alone or in combination with moxifloxacin. Neutral pH did not alter the therapeutic effect of GLY and would be preferred if used clinically.

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“…Therefore, we evaluated the anti-inflammatory effect of GC in the liver on HMGB1, TNF-α, and IL-Iβ, and anti-oxidation on SOD and MDA. Upon liver injury, the expression of HMGB1 would be transferred from nucleus to cytoplasm (Zhou et al, 2020). The positive expression of HMGB1 in livers of control was mostly observed in the cell nucleus ( Figure 4A), whereas transferred into the cytoplasm after CP treatment (p < 0.01), and the high expression in the cytoplasm was significantly reduced after GC-treatment (900 mg/kg).…”

Section: Effects Of Licorice On Indicators Related To Apoptosis Oxidmentioning

confidence: 96%