Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis

Fu, Yang; Wang, Denian; Wang, Shuang; Zhang, Qi; Líu, Hao; Yang, Shanshan; Xu, Yanming; Ying, Binwu

doi:10.1007/s00011-021-01493-8

Cited by 12 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Juan et al (95) proved that M1 and M2 macrophages have opposite effects on the pyroptosis of renal TECs in a co-culture system, which may lead to functional differences of their different phenotypes in the pathology of sepsis-AKI. Additional evidence showed that either CLP or LPS caused macrophage pyroptosis (93,96). Activated NLRP3 forms a protein complex (NLRP3 inflammasome) consisting of NLRP3, ASC and precaspase-1, and activated caspase-1 causes macrophage pyroptosis (97).…”

Section: Pyroptosismentioning

confidence: 99%

See 1 more Smart Citation

The Programmed Cell Death of Macrophages, Endothelial Cells, and Tubular Epithelial Cells in Sepsis-AKI

Wang

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Sepsis is a systemic inflammatory response syndrome caused by infection, following with acute injury to multiple organs. Sepsis-induced acute kidney injury (AKI) is currently recognized as one of the most severe complications related to sepsis. The pathophysiology of sepsis-AKI involves multiple cell types, including macrophages, vascular endothelial cells (ECs) and renal tubular epithelial cells (TECs), etc. More significantly, programmed cell death including apoptosis, necroptosis and pyroptosis could be triggered by sepsis in these types of cells, which enhances AKI progress. Moreover, the cross-talk and connections between these cells and cell death are critical for better understanding the pathophysiological basis of sepsis-AKI. Mitochondria dysfunction and oxidative stress are traditionally considered as the leading triggers of programmed cell death. Recent findings also highlight that autophagy, mitochondria quality control and epigenetic modification, which interact with programmed cell death, participate in the damage process in sepsis-AKI. The insightful understanding of the programmed cell death in sepsis-AKI could facilitate the development of effective treatment, as well as preventive methods.

show abstract

Section: Pyroptosismentioning

confidence: 99%

“…In sepsis-AKI, pyroptosis is observed in the cell types of macrophages, ECs and TECs ( 91 – 93 ). Compared to in vitro experiments, in vivo experiments showed even more severe pyroptosis in TECs.…”

Section: Types Of Programmed Cell Death In Sepsis-akimentioning

confidence: 99%

The Programmed Cell Death of Macrophages, Endothelial Cells, and Tubular Epithelial Cells in Sepsis-AKI

Wang

et al. 2021

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Subjects who died from multiple organ failure resulting from sepsis exhibited increased PD-L1 on macrophages and other APCs [ 121 ]. Additionally, a gradual increase in the level of PD-L1 was also seen in monocytes based on the increasing severity of sepsis, supporting the idea that unusual activation of the PD-1/PD-L1 pathway is a major cause of immunoparalysis in sepsis patients [ 122 , 123 ]. Nivolumab is a mAb targeting drug that has proven to be successful at immunomodulation during the treatment of cancer [ 124 ].…”

Section: Current Therapeutic Approaches To Treat Sepsismentioning

confidence: 61%

Recent Advances in Monoclonal Antibody-Based Approaches in the Management of Bacterial Sepsis

2023

View full text Add to dashboard Cite

Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory response to an infectious agent and its antigens. Immune cell activation against the antigens causes severe distress that mediates a strong inflammatory response in vital organs. Sepsis is responsible for a high rate of morbidity and mortality in immunosuppressed patients. Monoclonal antibody (mAb)-based therapeutic strategies are now being explored as a viable therapy option for severe sepsis and septic shock. Monoclonal antibodies may provide benefits through two major strategies: (a) monoclonal antibodies targeting the pathogen and its components, and (b) mAbs targeting inflammatory signaling may directly suppress the production of inflammatory mediators. The major focus of mAb therapies has been bacterial endotoxin (lipopolysaccharide), although other surface antigens are also being investigated for mAb therapy. Several promising candidates for mAbs are undergoing clinical trials at present. Despite several failures and the investigation of novel targets, mAb therapy provides a glimmer of hope for the treatment of severe bacterial sepsis and septic shock. In this review, mAb candidates, their efficacy against controlling infection, with special emphasis on potential roadblocks, and prospects are discussed.

show abstract

“…Similarly, in indirect ARDS, the concentration of sPD-1 in serum and BALF increased [ 143 ]. It is reported that high expression of PD-1 in monocytes may be involved in developing sepsis [ 144 ].…”

Section: Therapeutic Targets and Biomarkersmentioning

confidence: 99%

The role of lung macrophages in acute respiratory distress syndrome

Dang

Tao

et al. 2022

Inflamm. Res.

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) is an acute and diffuse inflammatory lung injury in a short time, one of the common severe manifestations of the respiratory system that endangers human life and health. As an innate immune cell, macrophages play a key role in the inflammatory response. For a long time, the role of pulmonary macrophages in ARDS has tended to revolve around the polarization of M1/M2. However, with the development of single-cell RNA sequencing, fate mapping, metabolomics, and other new technologies, a deeper understanding of the development process, classification, and function of macrophages in the lung are acquired. Here, we discuss the function of pulmonary macrophages in ARDS from the two dimensions of anatomical location and cell origin and describe the effects of cell metabolism and intercellular interaction on the function of macrophages. Besides, we explore the treatments for targeting macrophages, such as enhancing macrophage phagocytosis, regulating macrophage recruitment, and macrophage death. Considering the differences in responsiveness of different research groups to these treatments and the tremendous dynamic changes in the gene expression of monocyte/macrophage, we discussed the possibility of characterizing the gene expression of monocyte/macrophage as the biomarkers. We hope that this review will provide new insight into pulmonary macrophage function and therapeutic targets of ARDS.

show abstract

Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis

Cited by 12 publications

References 28 publications

The Programmed Cell Death of Macrophages, Endothelial Cells, and Tubular Epithelial Cells in Sepsis-AKI

The Programmed Cell Death of Macrophages, Endothelial Cells, and Tubular Epithelial Cells in Sepsis-AKI

Recent Advances in Monoclonal Antibody-Based Approaches in the Management of Bacterial Sepsis

The role of lung macrophages in acute respiratory distress syndrome

Contact Info

Product

Resources

About