Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus Gallus domesticus)

Aoki, Naoya; Fujita, Toshiyuki; Mori, Chihiro; Fujita, Eiko; Yamaguchi, Shinjiro; Matsushima, Toshiya; Homma, Koichi J.

doi:10.1016/j.bbr.2019.112291

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…In this study, a disc-based behavioral apparatus was found to be advantageous for the analysis of the learning process in imprinting. In previous studies, the runway-type ( Hess, 1959 ), wheel-type ( Horn, 1986 ), and treadmill-type apparatus have been used for the analysis of filial imprinting ( Izawa et al, 2001 ; Yamaguchi et al, 2012 ; Aoki et al, 2020 ). The wheel-type apparatus is advantageous while analyzing approach distances to the object because approach distances are automatically measurable ( Versace et al, 2017a , b ).…”

Section: Discussionmentioning

confidence: 99%

“…The learning processes of imprinting have been investigated in a laboratory setting since the 1960s ( Bateson, 1966 ; Horn, 1998 ). In these studies, the neuronal and molecular mechanisms of imprinting have been investigated extensively ( Horn, 1998 , 2004 ; Yamaguchi et al, 2012 ; Solomonia and McCabe, 2015 ; Aoki et al, 2018 , 2020 ). Additionally, several genes involved in memory formation during imprinting have been detected using comprehensive gene screening strategies ( Yamaguchi et al, 2008 , 2011a , 2011b , 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc

et al. 2022

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In filial imprinting, newly hatched chicks repeatedly approach a conspicuous object nearby and memorize it, even though it is an artificial object instead of their mother hen. Imprinting on an artificial object in a laboratory setting has a clear sensitive period from post hatch days 1–3 in the case of domestic chicks. However, the establishment of imprintability are difficult to investigate because of the limitations of the behavioral apparatus. In this study, we developed a novel behavioral apparatus, based on a running disc, to investigate the learning processes of imprinting in newly hatched domestic chicks. In the apparatus, the chick repeatedly approaches the imprinting object on the disc. The apparatus sends a transistor-transistor-logic signal every 1/10 turn of the disc to a personal computer through a data acquisition system following the chick’s approach to the imprinting object on the monitor. The imprinting training and tests were designed to define the three learning processes in imprinting. The first process is the one in which chicks spontaneously approach the moving object. The second is an acquired process in which chicks approach an object even when it is static. In the third process, chicks discriminate between the differently colored imprinting object and the control object in the preference test. Using the apparatus, the difference in the chicks’ behavior during or after the sensitive period was examined. During the sensitive period, the chicks at post hatch hour 12 and 18 developed the first imprinting training process. The chicks at post hatch hour 24 maintained learning until the second process. The chicks at post hatch hour 30 reached the discrimination process in the test. After the sensitive period, the chicks reared in darkness until post hatch day 4 exhibited poor first learning process in the training. Thus, this apparatus will be useful for the detection of behavioral changes during neuronal development and learning processes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc

et al. 2022

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“…These small molecules act on the corresponding targets and affect the human nervous system, with effects on learning and memory. 108,109 Polyphenols and their intestinal metabolites stimulate the production of intestinal secretions to affect the CNS. Gut microbes produce large amounts of neurotransmitters, which can produce specific signals to regulate the CNS.…”

Section: Through the Microbiota-gut-brain Axismentioning

confidence: 99%

Raspberry polyphenols alleviate neurodegenerative diseases: through gut microbiota and ROS signals

Shi

et al. 2023

Food Funct.

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“…Visual imprinting is a form of learning whereby newborn chicks form social attachment and depends on an area called the "intermediate medial mesopallium," in the medial part of the lateral pallium as well as other areas (Tiunova et al, 2019). M3 muscarinic cholinergic receptors of the intermediate medial mesopallium are necessary for imprinting (Aoki et al, 2020). M3 receptors are G q/11 -linked receptors and could potentially activate TRPC5.…”

Section: Pallium Hippocampus and Amygdalamentioning

confidence: 99%

Novel localizations of TRPC5 channels suggest novel and unexplored roles: A study in the chick embryo brain

Ahmed

Liu

Yip

et al. 2021

Developmental Neurobiology

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Mammalian TRPC5 channels are predominantly expressed in the brain, where they increase intracellular Ca 2+ and induce depolarization. Because they augment presynaptic vesicle release, cause persistent neural activity, and show constitutive activity, TRPC5s could play a functional role in late developmental brain events. We used immunohistochemistry to examine TRPC5 in the chick embryo brain between 8 and 20 days of incubation, and provide the first detailed description of their distribution in birds and in the whole brain of any animal species. Stained areas substantially increased between E8 and E16, and staining intensity in many areas peaked at E16, a time when chick brains first show organized patterns of whole-brain metabolic activation like what is seen consistently after hatching. Areas showing cell soma staining match areas showing Trpc5 mRNA or protein in adult rodents (cerebral cortex, hippocampus, amygdala, cerebellar Purkinje cells). Chick embryos show protein staining in the optic tectum, cerebellar nuclei, and several brainstem nuclei; equivalent areas in the Allen Institute mouse maps express Trpc5 mRNA. The strongest cell soma staining was found in a dorsal hypothalamic area (matching a group of parvicellular arginine vasotocin neurons and a pallial amygdalohypothalamic cell corridor) and the vagal motor complex. Purkinje cells showed strong dendritic staining at E20. Unexpectedly, we also describe neurite staining in the septum, several hypothalamic nuclei, and a paramedian raphe area; the strongest neurite staining was in the median eminence. These novel localizations suggest new unexplored TRPC5 functions, and possible roles in late embryonic brain development.

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Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus Gallus domesticus)

Cited by 10 publications

References 22 publications

Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc

Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc

Raspberry polyphenols alleviate neurodegenerative diseases: through gut microbiota and ROS signals

Novel localizations of TRPC5 channels suggest novel and unexplored roles: A study in the chick embryo brain

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