Blockade of Ovulation in the Hen with Adrenolytic and Parasympatholytic Drugs.

Zarrow, M. X.; Bastian, J. W.

doi:10.3181/00379727-84-20676

Cited by 24 publications

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“…This phenomenon is dependent upon the nerve supply to the distended area of the uterine horn. These observations suggest an interrelation between the uterus and the pituitary gland not unlike that involved in the neurogenic activation of the adenohypophysis which may result in the discharge of ovulating hormone (LH) in the rat (Everett, 1952), rabbit (Markee et al, 1952), cow (Hansel andTrimberger, 1951) and the chicken (Zarrow andBastian, 1953, van Tienhoven et al, 1954). It is said that the introduction of lead shot into the uterine horns of swine causes a cessation of estrous cycles and a general physiological state not unlike anestrus (Keller, 1924).…”

mentioning

confidence: 99%

FURTHER STUDIES ON THE NEUROGENIC CONTROL OF THE ESTROUS CYCLE BY UTERINE DISTENTION¹

1955

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T HE mechanism by which the corpus luteum is caused to persist following fertilization in mammals which ovulate spontaneously during each reproductive cycle and which do not show pseudopregnancy following cervical stimulation is not known. The effects of uterine distention and the apparent importance of the" uterine afferent nerve supply on the regulation of the estrous cycle of the ewe have been observed by Moore and Nalbandov (1953). They have shown that a foreign body introduced into the sheep uterus during the early luteal phase of the estrous cycle causes a marked decrease in the mean length of the estrous cycle. This phenomenon is dependent upon the nerve supply to the distended area of the uterine horn. Similarly Huston and Nalbandov (1953) and van Tienhoven (1953) have shown that oviducal stimulation may alter the qualitative and quantitative gondadotrophin secretion in the chicken. It is said that the introduction of lead shot into the uterine horns of swine causes a cessation of estrous cycles and a general physiological state not unlike anestrus (Keller, 1924). Velardo and co-workers (1953) found that prolongation of pseudopregnancy in the rat is related quantitatively to the amount of decidual tissue present, and ovulation and vaginal cornification are suppressed and the functional life of the corpora lutea is extended. These observations suggest an interrelation between the uterus and the pituitary gland not unlike that involved in the neurogenic activation of the adenohypophysis

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confidence: 99%

FURTHER STUDIES ON THE NEUROGENIC CONTROL OF THE ESTROUS CYCLE BY UTERINE DISTENTION¹

1955

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“…There are reports of androgen receptors in avian ( Yoshimura et al, 1995 ) and mammalian granulosa cells ( Hsueh et al, 1983 ). Nuclear estrogen receptor has been reported to be present in granulosa cells of the hen ( Zarrow and Bastian, 1953 ; Kamiyoshi et al, 1986 ). Action of steroid hormones, via nuclear receptors is required for long duration to induce de novo synthesis of protein ( Knecht et al, 1985 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Steroid Hormone in Avian Follicles

Rivas

Nieto

Kamiyoshi

2016

Asian Australas. J. Anim. Sci

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The aim of the present study was to examine the effects of testosterone (T) and estradiol-17β (E2) on the production of progesterone (P4) by granulosa cells, and of the E2 on the production of P4 and T by theca internal cells. In the first experiment, granulosa cells isolated from the largest (F1) and third largest (F3) preovulatory follicle were incubated for 4 h in short-term culture system, P4 production by granulosa cells of both F1 and F3 was increased in a dose-dependent manner by ovine luteinizing hormone (oLH), but not T or E2. In the second experiment, F1 and F3 granulosa cells cultured for 48 h in the developed monolayer culture system were recultured for an additional 48 h with increasing doses of various physiological active substances existing in the ovary, including T and E2. Basal P4 production for 48 h during 48 to 96 h of the cultured was about nine fold greater by F1 granulosa cells than by F3 granulosa cells. In substances examined oLH, chicken vasoactive intestinal polypeptide (cVIP) and T, but not E2, stimulated in a dose-dependent manner P4 production in both F1 and F3 granulosa cells. In addition, when the time course of P4 production by F1 granulosa cells in response to oLH, cVIP, T and E2 was examined for 48 h during 48 to 96 h of culture, although E2 had no effect on P4 production by granulosa cells of F1 during the period from 48 to 96 h of culture, P4 production with oLH was found to be increased at 4 h of the culture, with a maximal 9.14 fold level at 6 h. By contrast, P4 production with cVIP and T increased significantly (p<0.05) from 8 and 12 h of the culture, respectively, with maximal 6.50 fold response at 12 h and 6, 48 fold responses at 36 h. Furthermore, when F1 granulosa cells were precultured with E2 for various times before 4 h culture with oLH at 96 h of culture, the increase in P4 production in response to oLH with a dose-related manner was only found at a pretreatment time of more than 12 h. In the third experiment, theca internal cells of F1, F2 and the largest third to fifth preovulatory follicles (F3-5) were incubated for 4 h in short-term culture system with increasing doses of E2. The production of P4 and T by theca internal cells were increased with the addition of E2 of 10−6 M. These increases were greater in smaller follicles. These results indicate that, in granulosa cells of the hen, T may have a direct stimulatory action in the long term on P4 production, and on E2 in long-term action which may enhance the sensitivity to LH for P4 production, and thus, in theca internal cells, E2 in short term action may stimulate the production of P4 and T.

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“…In the hen, ovulation can be blocked by drugs, but pharma? cological details seem to differ from those seen in mammals: the barbiturates are inactive, but atropine and SKF-501 work (10 …”

Section: March 1961 615mentioning

confidence: 90%

Endocrine Pharmacology

Gaunt¹,

Chart²,

Renzi³

1961

Science

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Blockade of Ovulation in the Hen with Adrenolytic and Parasympatholytic Drugs.

Cited by 24 publications

References 1 publication

FURTHER STUDIES ON THE NEUROGENIC CONTROL OF THE ESTROUS CYCLE BY UTERINE DISTENTION¹

FURTHER STUDIES ON THE NEUROGENIC CONTROL OF THE ESTROUS CYCLE BY UTERINE DISTENTION¹

Effects of Steroid Hormone in Avian Follicles

Endocrine Pharmacology

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Blockade of Ovulation in the Hen with Adrenolytic and Parasympatholytic Drugs.

Cited by 24 publications

References 1 publication

FURTHER STUDIES ON THE NEUROGENIC CONTROL OF THE ESTROUS CYCLE BY UTERINE DISTENTION1

FURTHER STUDIES ON THE NEUROGENIC CONTROL OF THE ESTROUS CYCLE BY UTERINE DISTENTION1

Effects of Steroid Hormone in Avian Follicles

Endocrine Pharmacology

Contact Info

Product

Resources

About

FURTHER STUDIES ON THE NEUROGENIC CONTROL OF THE ESTROUS CYCLE BY UTERINE DISTENTION¹

FURTHER STUDIES ON THE NEUROGENIC CONTROL OF THE ESTROUS CYCLE BY UTERINE DISTENTION¹