Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801

Karler, Ralph; Calder, Larry D.; Chaudhry, Imtiaz A.; Turkanis, Stuart A.

doi:10.1016/0024-3205(89)90045-3

Cited by 471 publications

(211 citation statements)

References 8 publications

Supporting

Mentioning

201

Contrasting

Unclassified

Order By: Relevance

“…Most research has studied this process using locomotor sensitization as a model (Kilbey and Ellinwood, 1977;Karler et al, 1989Karler et al, , 1990Kalivas and Duffy, 1993a, b;Vanderschuren et al, 1999), and a number of labs are now examining the link between psychostimulantinduced locomotor activation and self-administration. For example, self-administration of cocaine produces sensitization to the locomotor-activating effects (Hooks et al, 1994;Phillips and Di Ciano, 1996;Zapata et al, 2003;Ben-Shahar et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

Morgan

Liu

Roberts

2005

Neuropsychopharmacol

View full text Add to dashboard Cite

The development of drug addiction involves a transition from recreational use to compulsive drug seeking and taking, and this progression can occur rapidly with cocaine use. These data highlight the importance of early drug exposure and the development of drug dependence; however, little experimental attention has been paid to this phenomenon in animal models of drug abuse. The present experiments demonstrate a progressive and rapid sensitization to the reinforcing strength of cocaine assessed using a progressive ratio (PR) schedule in rats. The first experiment found that rats show increased breakpoints over a 2-week period following acquisition. Subsequent experiments examined the role of total cocaine intake during the initial exposure period and found that low intakes (20 mg/ kg/day Â 5 days) resulted in sensitization, whereas relatively higher intake (60 or 100 mg/kg/day Â 5 days) suppressed the development of sensitization. In contrast, this higher level of intake (60 mg/kg/day Â 5 days) only transiently suppressed the expression of sensitization. Examination of breakpoints maintained by various doses of cocaine revealed an upward and leftward displacement of the cocaine doseeffect curve, relative to nonsensitized animals. These studies describe a form of sensitization that occurs rapidly to the reinforcing effects of cocaine, and provide a model to study the potential impact of initial experience on the development of drug dependence.

show abstract

Section: Discussionmentioning

confidence: 99%

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

Morgan

Liu

Roberts

2005

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…The systemic administration of either NMDA (Karler et al, 1989;Wolf et al, 1995) or AMPA/kainate (Karler et al, 1991a;Li et al, 1997;cf Akiyama et al, 1998) receptor antagonists as well as the application into the VTA of either NMDA (Cador et al, 1999;Vezina and Queen, 2000) or mGlu (Kim and Vezina, 1998) receptor antagonists has been shown to prevent the induction of AMPH-induced locomotor sensitization. Moreover, systemically administering NMDA receptor antagonists with AMPH during preexposure also prevents cellular correlates of locomotor Figure 6 Injection cannula tip placements in the VTA.…”

Section: Induction Of Sensitization By Amph Requires Activation Of Glmentioning

confidence: 99%

“…Indeed, induction of locomotor sensitization by AMPH has been shown to be dependent on activation of Nmethyl-D-aspartate (NMDA: Cador et al, 1999;Vezina and Queen, 2000) and metabotropic glutamate (mGlu: Kim and Vezina, 1998) receptors in the VTA. Systemic administration of NMDA (Karler et al, 1989;Wolf et al, 1995) or a-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA)/kainate receptor antagonists (Karler et al, 1991a;Li et al, 1997) also prevents the development of locomotor sensitization by systemic AMPH. Moreover, induction of locomotor sensitization by AMPH is blocked by lesions of the PFC, which provides major glutamatergic afferentation to the VTA Cador et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Previous Exposure to VTA Amphetamine Enhances Cocaine Self-Administration under a Progressive Ratio Schedule in an NMDA, AMPA/Kainate, and Metabotropic Glutamate Receptor-Dependent Manner

Suto

Tanabe

Austin

et al. 2003

Neuropsychopharmacol

View full text Add to dashboard Cite

Previous exposure to amphetamine (AMPH) in the ventral tegmental area (VTA) enhances cocaine self-administration in a D 1 dopamine receptor-dependent manner. The present study examined the contribution of VTA NMDA, AMPA/kainate, and metabotropic glutamate (mGlu) receptors to this effect. Rats in different groups received three intra-VTA injections, one every third day, of either saline (0.5 ml/ side), AMPH (2.5 mg/0.5 ml/side), AMPH+CPP (NMDA receptor antagonist; 10 mM or 100 mM/0.5 ml/side), AMPH+CNQX (AMPA/ kainate receptor antagonist; 0.3 mM or 1 mM/0.5 ml/side), AMPH+MCPG (mGlu receptor antagonist; 0.5 mM or 50 mM/0.5 ml/side), or the glutamate receptor antagonists alone. Starting 7-10 days after the last pre-exposure injection, rats were trained to self-administer cocaine (0.3 mg/kg/infusion) and then tested under a progressive ratio (PR) schedule of reinforcement for 6 consecutive days. As reported previously, VTA AMPH pre-exposed rats worked more and obtained more infusions of cocaine than saline pre-exposed animals. Coadministration of CPP, CNQX, or MCPG with AMPH during pre-exposure dose-dependently blocked this enhancement of cocaine self-administration. Rats pre-exposed to the glutamate receptor antagonists alone did not differ on the test days from the saline pre-exposed controls. These results indicate that, in a manner paralleling the induction of sensitization of the locomotor stimulating effects of AMPH, activation of NMDA, AMPA/kainate, and mGlu receptors during pre-exposure to AMPH in the VTA is necessary for the enhancement of cocaine self-administration to develop.

show abstract

“…One interesting feature of sensitization is its long-lasting aspect (Robinson and Becker 1986;Woolverton and Johnson 1992) that is reminiscent of long-term potentiation (LTP) and other N-methyl-D-aspartate (NMDA) receptor-mediated events. Indeed, extracellular levels of glutamate increase in the ventral tegmental area (VTA) after cocaine administration in sensitized rats (Kalivas and Duffy 1998) and inhibition of the NMDA receptor has been shown to block sensitization induced by psychostimulants (Karler et al 1989, see also Vanderschuren and Kalivas 2000, for review). These data strongly suggest that hyperactivity of not only the dopaminergic but also the glutamatergic system is involved in cocaine-induced sensitization.…”

Section: Introductionmentioning

confidence: 99%

Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats

et al. 2002

View full text Add to dashboard Cite

Rationale-Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the opioid receptor-like (ORL-1) receptor, shows similarities to dynorphin A (1−17) in structure and functions. Dynorphin and other kappa opioid receptor agonists have been shown to block cocaine sensitization.Objective-The present study was designed to examine the ability of OFQ/N to block cocaineinduced behavioral sensitization.Methods-Rats were habituated to testing chambers for 1 h, injected with artificial cerebrospinal fluid (aCSF) or OFQ/N (15 nmol) followed by saline or cocaine (20 mg/kg) and locomotor activity was measured for a further 1 h. Rats were treated similarly for the next 2 days except the dose of OFQ/N was doubled on each subsequent day. Rats were then challenged with cocaine (7.5 mg/kg) in the absence of OFQ/N on day 8. The specificity of OFQ/N's action was examined in the presence of J-113397 (30 nmol), an ORL-1 receptor antagonist. The ability of OFQ/N to block the contextindependent component of cocaine sensitization was also tested wherein rats were treated in their home cages on days 1−3. Finally, the effect of intra-VTA OFQ/N administration on cocaine sensitization was examined.Results-Sensitization did not develop in rats repeatedly treated with OFQ/N, via either route of administration, prior to cocaine administration on days 1−3. The inhibitory effect of OFQ/N was not dependent on context and was blocked by pretreatment with J-113397.Conclusion-Our results indicate that OFQ/N blocks cocaine-induced behavioral sensitization through activation of the ORL-1 receptor and that the VTA may be one of the substrates for this action of OFQ/N.

show abstract

Blockade of “reverse tolerance” to cocaine and amphetamine by MK-801

Cited by 471 publications

References 8 publications

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

Previous Exposure to VTA Amphetamine Enhances Cocaine Self-Administration under a Progressive Ratio Schedule in an NMDA, AMPA/Kainate, and Metabotropic Glutamate Receptor-Dependent Manner

Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats

Contact Info

Product

Resources

About