Blockade of serotonin 5-HT 1B and 5-HT 2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes

Millan, Mark J.; Veiga, Sylvie; Girardon, Sylvie; Brocco, Mauricette

doi:10.1007/s00213-003-1389-y

Cited by 42 publications

(25 citation statements)

References 109 publications

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“…Both paradigms are used for measuring state anxiety that is based on the conflict between exploration of novel environments and the avoidance of potentially dangerous situations (Hogg, 1996;Rodgers and Dalvi, 1997;Hascoet et al, 2001;Millan et al, 2003;de Sousa et al, 2006). TRPV1-KO much faster adapted to the aversive light compartment, spent more time in the light compartment in the light-dark test, and explored the open arms of the elevated plus maze more intensively than their wild-type littermates, indicating that they are less anxious.…”

Section: Discussionmentioning

confidence: 99%

Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

Marsch¹,

Foeller²,

Rammes³

et al. 2007

J. Neurosci.

317

230

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The transient receptor potential vanilloid type 1 channel (TRPV1) (formerly called vanilloid receptor VR1) is known for its key role of functions in sensory nerves such as perception of inflammatory and thermal pain. Much less is known about the physiological significance of the TRPV1 expression in the brain. Here we demonstrate that TRPV1 knock-out mice (TRPV1-KO) show less anxiety-related behavior in the light-dark test and in the elevated plus maze than their wild-type littermates with no differences in locomotion. Furthermore, TRPV1-KO mice showed less freezing to a tone after auditory fear conditioning and stress sensitization. This reduction of conditioned and sensitized fear could not be explained by alterations in nociception. Also, tone perception per se was unaffected, as revealed by determination of auditory thresholds through auditory brainstem responses and distortion-product otoacoustic emissions. TRPV1-KO showed also less contextual fear if assessed 1 d or 1 month after strong conditioning protocols. These impairments in hippocampusdependent learning were mirrored by a decrease in long-term potentiation in the Schaffer collateral-commissural pathway to CA1 hippocampal neurons. Our data provide first evidence for fear-promoting effects of TRPV1 with respect to both innate and conditioned fear and for a decisive role of this receptor in synaptic plasticity.

show abstract

Section: Discussionmentioning

confidence: 99%

Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

Marsch¹,

Foeller²,

Rammes³

et al. 2007

J. Neurosci.

317

230

View full text Add to dashboard Cite

show abstract

“…Systemic treatment with the 5-HT3-R antagonist ondansetron can augment the antidepressant-like actions of SRIs in the forced swim and tail suspension tests, while the 5-HT3-R agonist 1-(m-chlorophenyl)-biguanide (mCPBG) has the opposite effect (Nakagawa et al, 1998;Redrobe and Bourin, 1997) (cf. Akagawa et al, 1999;Millan et al, 2003). 5-HT3A-R knockout mice do not display changes in baseline behaviors in these tests with the exception of increased 'depression-related' behavior in female knockouts with repeated forced swim exposure (Bhatnagar et al, 2004a).…”

Section: -Ht3 Receptorsmentioning

confidence: 98%

Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease

Holmes

2008

Neuroscience & Biobehavioral Reviews

249

166

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The serotonin system is strongly implicated in the pathophysiology and therapeutic alleviation of stress-related disorders such as anxiety and depression. Serotonergic modulation of the acute response to stress and the adaptation to chronic stress is mediated by a myriad of molecules controlling serotonin neuron development (Pet-1), synthesis (tryptophan hydroxylase 1 and 2 isozymes), packaging (vesicular monoamine transporter 2), actions at presynaptic and postsynaptic receptors (5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT3A, 5-HT4, 5-HT5A, 5-HT6, 5-HT7), reuptake (serotonin transporter), and degradation (monoamine oxidase A). A growing body of evidence from preclinical rodents models, and especially genetically modified mice and inbred mouse strains, has provided significant insight into how genetic variation in these molecules can affect the development and function of a key neural circuit between the dorsal raphe nucleus, medial prefrontal cortex and amygdala. By extension, such variation is hypothesized to have a major influence on individual differences in the stress response and risk for stress-related disease in humans. The current article provides an update on this rapidly evolving field of research.

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“…Interestingly, antidepressants such as fluoxetine and citalopram also exhibit a behavioral profile distinctive from that of antipsychotics. Acute fluoxetine or citalopram increases amphetamine-induced hyperlocomotion Millan et al, 2003) but has no effect on phencyclidine-induced model (Redmond et al, 1999). Repeated fluoxetine or citalopram treatment tends to enhance amphetamine-induced hyperlocomotion (Arnt et al, 1984;Sills et al, 1999Sills et al, , 2000 and phencyclidine-induced hyperlocomotion (Redmond et al, 1999).…”

Section: Acknowledgementsmentioning

confidence: 99%

Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibition on amphetamine-induced hyperlocomotion: Relevance to animal models of antipsychotic drugs

Sun

2009

European Journal of Pharmacology

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Blockade of serotonin 5-HT 1B and 5-HT 2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes

Cited by 42 publications

References 109 publications

Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

Reduced Anxiety, Conditioned Fear, and Hippocampal Long-Term Potentiation in Transient Receptor Potential Vanilloid Type 1 Receptor-Deficient Mice

Genetic variation in cortico-amygdala serotonin function and risk for stress-related disease

Repeated antipsychotic treatment progressively potentiates inhibition on phencyclidine-induced hyperlocomotion, but attenuates inhibition on amphetamine-induced hyperlocomotion: Relevance to animal models of antipsychotic drugs

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