Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats

Quinlan, Matthew G.; Sharf, Ruth; Lee, David Y.; Wise, Roy A.; Ranaldi, Robert

doi:10.1007/s00213-003-1771-9

Cited by 22 publications

(14 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, previous literature suggests that our infusion parameters should have been sensitive enough to produce region-specific effects between the amygdala and dorsal anatomical control infusion sites. Intracranial SCH-23390 infusion has produced region-specific behavioral effects with doses comparable to or higher than those used in the present study and with only 1-2 mm distance between target and dorsal anatomical control sites (Epping-Jordan et al, 1998;Ranaldi and Wise, 2001;Anderson et al, 2003;Quinlan et al, 2004), even following infusion into the BLA (Nader and LeDoux, 1999). Nevertheless, Caine et al (1995) demonstrated that infusion of [ 3 H]SCH-23390 into the CEA produces a diffusion field of approximately 2 mm 3 after an hour.…”

Section: Discussionsupporting

confidence: 42%

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Alleweireldt

Hobbs

Taylor

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

Amygdala D1 receptors have been implicated in the motivating effects of cocaine-conditioned cues and cocaine itself, but the specific nucleus involved is unclear. Thus, we infused the D1 antagonist, SCH-23390, into the rostral basolateral amygdala (rBLA), caudal basolateral amygdala (cBLA), or central amygdala (CEA), and tested its effects on self-administration of cocaine, as well as reinstatement of extinguished cocaine-seeking behavior by cocaine-conditioned cues or cocaine itself. Two anatomical controls, the posterior regions of basal ganglia (BG) and somatosensory/insular cortices (CTX), were also examined. Cocaine self-administration was increased and cue and cocaine reinstatement were decreased by SCH-23390 infusion into every region when examined across the hour test session, with the exception that cBLA infusion did not alter cocaine reinstatement. In the first 20 min of the session, when SCH-23390 was more localized in the target sites, self-administration was increased by infusion into the CEA, cBLA, BG, and CTX, with lesser increases in the rBLA. Cocaine reinstatement was attenuated during the first 20 min only by infusion into the CEA, rBLA, and CTX. Cue reinstatement was not reliably observed in the first 20 min, but there was a trend for attenuation by infusion into the cBLA, and surprisingly, significant attenuations in the BG and CTX. The findings suggest that D1 receptors in subregions of the amygdala play differential roles in the reinforcing/motivational effects of cocaine, while the cue reinstatement effects are less clear. Further research is needed to examine the novel findings that neighboring regions of the BG and CTX may play a role in motivation for cocaine.

show abstract

Section: Discussionsupporting

confidence: 42%

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Alleweireldt

Hobbs

Taylor

et al. 2005

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…Along with dendritic release of DA in the VTA, dendritically released DA in the substantia nigra [103,104] also has been shown to contribute to the rewarding effects of intravenously self-administered cocaine [105]. Therefore, it appears that the rewarding effects of cocaine are not restricted to the drug's ability to elevate DA levels in terminal regions of the mesocorticolimbic DA system but also are dependent on DA stimulation of D1 receptors in the VTA and substantia nigra.…”

Section: Discussionmentioning

confidence: 96%

Microinjections of a dopamine D1 receptor antagonist into the ventral tegmental area block the expression of cocaine conditioned place preference in rats

Galaj¹,

Manuszak²,

Arastehmanesh³

et al. 2014

Behavioural Brain Research

View full text Add to dashboard Cite

“…First hints were provided by the observations that electrical stimulation of nigrostriatal DAergic cells and terminal fields produced rewarding effects (Crow 1972;Prado-Alcala and Wise 1984;Wise 1981) and that selective lesions of the nigrostriatal pathway attenuated drug self-administration (Glick et al 1975;Linseman 1976). Those early studies have been backed up by the results of further experimentation (Suto et al 2004), including the demonstration that intra-nigral infusions of D1 receptor antagonists reduce drug self-administration (Quinlan et al 2004).…”

Section: Els Targets Mesocorticolimbic Daergic Circuits: Impact On Admentioning

confidence: 97%

Potential programming of dopaminergic circuits by early life stress

et al. 2010

View full text Add to dashboard Cite

Stress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical, and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime susceptibility to psychiatric disorders, including drug addiction. This article is intended to serve as a starting point for future studies aimed at the attenuation or reversal of the effects of adverse early life events on dopamine-regulated behaviors.

show abstract

Blockade of substantia nigra dopamine D1 receptors reduces intravenous cocaine reward in rats

Cited by 22 publications

References 39 publications

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Effects of SCH-23390 Infused into the Amygdala or Adjacent Cortex and Basal Ganglia on Cocaine Seeking and Self-Administration in Rats

Microinjections of a dopamine D1 receptor antagonist into the ventral tegmental area block the expression of cocaine conditioned place preference in rats

Potential programming of dopaminergic circuits by early life stress

Contact Info

Product

Resources

About