Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists

Detke, Michael J.; Wieland, Scott; Lucki, Irwin

doi:10.1007/bf02246053

Cited by 120 publications

(74 citation statements)

References 39 publications

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“…Chronic, but not subchronic, administration of the tricyclic antidepressant desipramine was also effective at reducing immobility (F(1,28) ¼ 5.840, po0.05) and increasing climbing (F(1,28) ¼ 8.147, po0.01). The dissociation between SSRIs and tricyclics to differentially affect the distinct active behaviors of swimming and climbing, respectively, has been reported previously (Detke et al, 1995). Additionally, we did not detect an effect of the antipsychotic haloperidol (1 mg/ kg/day) in the FST either when administered subchronically or chronically.…”

Section: Fst Specifically Detects Antidepressant Effects and Depends supporting

confidence: 77%

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Holick

Lee

Hen

et al. 2007

Neuropsychopharmacol

277

206

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We previously reported that chronic, but not subchronic, treatment with the selective serotonin reuptake inhibitor (SSRI) fluoxetine altered behavior in the forced swimming test (FST) in BALB/cJ mice. We now use this model to investigate mechanisms underlying the delayed onset of the behavioral response to antidepressants, specifically (1) adult hippocampal neurogenesis and (2) expression of the 5-HT1A receptor. Here, we show data validating this model of chronic antidepressant action. We found the FST to be selectively responsive to chronic administration of the SSRI fluoxetine (18 mg/kg/day) and the tricyclic antidepressant desipramine (20 mg/kg/day), but not to the antipsychotic haloperidol (1 mg/kg/day) in BALB/cJ mice. The behavioral effects of fluoxetine emerged by 12 days of treatment, and were affected neither by ablation of progenitor cells of the hippocampus nor by genetic deletion of the 5-HT1A receptor. The effect of fluoxetine in the BALB/cJ mice was also neurogenesis-independent in the novelty-induced hypophagia test. We also found that chronic fluoxetine does not induce an increase in cell proliferation or the number of young neurons as measured by BrdU and doublecortin immunolabeling, respectively, in BALB/cJ mice. These data are in contrast to our previous report using a different strain of mice (129SvEvTac). In conclusion, we find that BALB/cJ mice show a robust response to chronic SSRI treatment in the FST, which is not mediated by an increase in new neurons in the hippocampus, and does not require the 5-HT1A receptor. These findings suggest that SSRIs can produce antidepressant-like effects via distinct mechanisms in different mouse strains.

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Section: Fst Specifically Detects Antidepressant Effects and Depends supporting

confidence: 77%

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Holick

Lee

Hen

et al. 2007

Neuropsychopharmacol

277

206

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“…8-OH-DPAT boosted the antiimmobility effects produced by the NRI desipramine, and dose-dependently potentiated the drug induced climbing behavior (Figure 4). These results are consistent with 5-HT 1A -receptor antagonists preventing the antidepressantlike effects of desipramine in the FST (Detke et al 1995c).…”

Section: Discussionmentioning

confidence: 46%

Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test

Reneric

Bouvard

Stinus

2001

Neuropsychopharmacology

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The rat forced swimming test (FST) predicts the efficacy of antidepressants, which decrease immobility duration in the test, and can distinguish selective serotonin (5-HT) and noradrenaline (NA) reuptake inhibitors, which, respectively, increase swimming and climbing behaviors. However, dual 5-HT and NA reuptake-inhibition produces climbing behavior solely, thereby suggesting with other data that the NA-system mediates inhibiting interactions on 5-HT-induced swimming in the FST. Since ␣ 2 -adrenoreceptors and 5-HT 1A -receptors have important regulatory functions and are involved in 5-HT/NA interactions, we examined whether the ␣ 2 -receptorantagonist idazoxan and the 5-HT 1A -receptor-agonist 8-hydroxy-2-(di-n -propylamino)-tetralin (8-OH-DPAT) would modify the behavioral pattern induced in the FST by either selective or non-selective antidepressant treatments. The rats were treated subacutely (3 injections IP over 48 h) with: (a) idazoxan (0.5-10 mg/kg) alone, and in combination with desipramine (10 mg/kg), or desipramine ϩ fluoxetine (10/10 mg/kg), or the dual serotonin/ noradrenaline reuptake-inhibitor milnacipran (20 mg/kg). (b) 8-OH- (Porsolt et al. 1977(Porsolt et al. , 1978(Porsolt et al. , 1979, which detects all the major classes of antidepressant treatments (Borsini and Meli 1988) NO . 4 (MAOIs), atypical antidepressants, and electroconvulsive shock. The FST is also used to investigate the mechanisms of action of antidepressant drugs (Borsini 1995) or the functional interactions that occur when antidepressants are administered (Redrobe and Bourin 1999;Rénéric and Lucki 1998). The rat FST consists of placing the animal in a jar filled with water for a pre-test on day 1, and for a five-minute test session 24 hours later, with the drugs being administered sub-acutely (3 injections) between the two sessions. The animal first attempts to escape and then progressively adopts an immobile posture, making only small movements to keep its head above water. Effective antidepressant treatments decrease the duration of immobility in the test session (Porsolt et al. 1978). Other methods of scoring the FST take into account swimming and climbing, two main active behaviors occurring in the test, which contribute to the antidepressant-like decrease in immobility-duration (Detke et al. 1995b). This procedure showed that noradrenaline (NA)-reuptake inhibitors (NRIs) and selective serotonin (5-hydroxytryptamine/ 5-HT)-reuptake inhibitors (SSRIs) increased selectively and respectively climbing and swimming behavior (Detke et al. 1995b). This technique can thus distinguish components to the behavioral response to antidepressants (Lucki 1997), which is in agreement with distinguishable neurochemical and behavioral contributions to the therapeutic effects of antidepressants in humans (Heninger et al. 1996;Katz et al. 1994).Serotonin and noradrenaline systems are directly involved in the pathogenesis and the recovery from depression (Blier et al. 1990;Caldecott Hazard et al. 1991), and there were clinical suggestions that...

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“…Moreover, the protective effect of long-term fluoxetine is only slightly inhibited by SCH 23390, it is mimicked by 8-OH-DPAT, a selective 5-HT 1A receptor agonist, and it is cancelled by (-)-pindolol (Gambarana et al 1995a, Gambarana et al unpublished observations). Pindolol also blocks the protective effect of 8-OH-DPAT in the forced swim test (Detke et al 1995). The antidepressant activity of H. perforatum showed the same sensitivity to the administration of SCH 23390 after both acute and repeated treatment.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of an Hypericum Perforatum (St. John's Wort) Extract in Preventing and Reverting a Condition of Escape Deficit in Rats

Gambarana

1999

Neuropsychopharmacology

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Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists

Cited by 120 publications

References 39 publications

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor

Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test

Efficacy of an Hypericum Perforatum (St. John's Wort) Extract in Preventing and Reverting a Condition of Escape Deficit in Rats

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