“…81,164,180 BK is the primary ligand for B2R, whereas des-Arg 9 -BK is the primary ligand for B1R. 85,107,148 Kinins are potent inflammatory mediators, 36,88,164 increasing vascular permeability 85,180,181 and neutrophil recruitment. 56,148,174 This may lead to inflammation, 25,148,180 edema, 75,164,180 and pain.…”