Blockade of the orexin receptors in the CA1 region of hippocampus decreased the lateral hypothalamic-induced antinociceptive responses in the model of orofacial formalin test in the rats

Haghparast, Amir; Shafiei, Iman; Alizadeh, Amir-Mohammad; Ezzatpanah, Somayeh; Haghparast, Abbas

doi:10.1016/j.peptides.2017.10.006

Cited by 24 publications

(12 citation statements)

References 31 publications

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“…Indeed, pharmacological studies showed an interaction between limbic structures and orofacial pain as found in Haghparast et al (2018). It has been reported that carbachol microinjections into the hippocampus reduced formalin-induced orofacial nociception in acute orofacial pain (Haghparast et al, 2018). Moreover, Pourrahimi et al (2019) evidenced a significant increase in c-fos expression in the vlPAG following intradental capsaicin.…”

Section: Discussionmentioning

confidence: 95%

“…Our data evidenced that the activity profile of the MMPs found on the hippocampus and vlPAG was higher compared with another limbic structure. Indeed, pharmacological studies showed an interaction between limbic structures and orofacial pain as found in Haghparast et al (2018). It has been reported that carbachol microinjections into the hippocampus reduced formalin-induced orofacial nociception in acute orofacial pain (Haghparast et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

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Temporomandibular inflammation regulates the matrix metalloproteinases MMP‐2 and MMP‐9 in limbic structures

Nascimento

Paula

Gerlach

et al. 2021

Journal Cellular Physiology

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Temporomandibular disorder (TMD) is characterized by acute or chronic orofacial pain, which can be associated with inflammatory processes in the temporomandibular joint (TMJ) and emotional disorders. Peripheral and central sensitization in painful orofacial processes is common, and it can be triggered by peripheral inflammatory challenge with consequent neuroinflammation phenomena. Such neuroinflammation comes from inflammatory products from supportive cells, blood-brain barrier, and extracellular matrix. Here, we evaluated the possible recruitment of limbic structures for modified matrix metalloproteinases (MMPs) expression and activity during temporomandibular inflammation-induced orofacial persistent pain. The inflammatory process in TMJs of rats was induced by Freund's Complete Adjuvant (CFA) administration.The activity and expression of MMPs-2 and 9 were assessed by in situ zymography and conventional zymography, respectively. A glial colocalization with the MMPs was performed using immunofluorescence. The results evidenced both short-and long-term alterations on MMP-2 and -9 expression in the limbic structures following CFA-induced temporomandibular inflammation. The gelatinolytic activity was increased in the central amygdala, hippocampus, hypothalamus, ventrolateral periaqueductal gray (vlPAG), superior colliculus, and inferior colliculus. Finally, an increase of colocalization of MMP-2/GFAP and MMP-9/GFAP in CFA-induced inflammation groups was observed when compared with saline groups in the central amygdala and vlPAG. It is possible to suggest that glial activation is partly responsible for the production of gelatinases in the persistent orofacial pain, and it is involved in the initiation and maintenance of this process, indicating that inhibition of MMPs might be pursued as a potential new therapeutic target for TMD.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Temporomandibular inflammation regulates the matrix metalloproteinases MMP‐2 and MMP‐9 in limbic structures

Nascimento

Paula

Gerlach

et al. 2021

Journal Cellular Physiology

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“…, Haghparast et al . ). A primarily electrophysiology study demonstrated that intravenous orexin‐A injection can attenuate the activity of trigeminovascular nociceptive afferents (Holland et al .…”

Section: Discussionmentioning

confidence: 97%

“…, Haghparast et al . ). Certainly, a recent study indicated that orexin‐A microinjection in spinal trigeminal nucleus caudalis (Vc) was able to suppress the severity of orofacial nociception induced by subcutaneous intralip injection of capsaicin (Kooshki et al .…”

Section: Introductionmentioning

confidence: 97%

Activation of orexin‐1 receptors in the ventrolateral periaqueductal grey matter (vlPAG) modulates pulpal nociception and the induction of substance P in vlPAG and trigeminal nucleus caudalis

et al. 2018

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“…In the current study and other similar studies, it has been shown that chemical stimulation of LH using carbachol attenuates formalin nociception in a dose-dependent manner. [25][26][27][28][29] Orexin neurons in the LH receive massive cholinergic input. So carbachol as a potent muscarinic cholinergic receptor agonist is able to increase the activity of these neurons.…”

Section: Discussionmentioning

confidence: 99%

<p>Role of Dopaminergic Receptors Within the Ventral Tegmental Area in Antinociception Induced by Chemical Stimulation of the Lateral Hypothalamus in an Animal Model of Orofacial Pain</p>

Matini

Haghparast

Rezaee

et al. 2020

JPR

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Introduction:The ventral tegmental area (VTA), as one of the classical components of the brain reward circuitry, shares large neural networks with the pain processing system. We previously showed the role of VTA dopamine receptors in modulation of lateral hypothalamus (LH)-induced antinociception in acute pain conditions. However, considering the fact that the neural systems involved in the mediation of tonic pain are not the same as those that mediate phasic pain. In the present study, we aimed to examine the role of intra-VTA dopamine receptors in LH-induced antinociceptive responses during tonic orofacial pain conditions. Methods: Male Wistar rats weighing 230-250 g were implanted with two separate cannulae into the LH and VTA on the same side. Different solutions of carbachol (62.5, 125 and 250 nM), as a non-selective cholinergic receptor agonist that activates the LH projecting neurons, were microinjected into the LH. In the other groups, D1-like dopamine receptor antagonist, SCH-23390 (0.25, 1 and 4 µg/03 µL saline) or D2-like dopamine receptor antagonist, Sulpiride (0.25, 1 and 4 µg/0.3 µL DMSO 12%) were microinjected into VTA, 5 min prior intra-LH carbachol (250 nM), then subjected to orofacial formalin test. Intra-LH carbachol microinjection dose-dependently attenuated biphasic orofacial pain. Results: Intra-VTA administration of SCH-23390 or Sulpiride dose-dependently decreased intra-LH carbachol-induced antinociception during both phases of orofacial formalin test with further effects in the late phase. Discussion: The findings suggest that chemical stimulation of the LH by carbachol possibly activates the orexin projecting neurons and subsequently, the VTA dopaminergic neurons involved in the orofacial pain modulation. Detecting such neural circuitry offers an alternative approach in the development of more efficient therapies for such debilitating pain conditions.

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Blockade of the orexin receptors in the CA1 region of hippocampus decreased the lateral hypothalamic-induced antinociceptive responses in the model of orofacial formalin test in the rats

Cited by 24 publications

References 31 publications

Temporomandibular inflammation regulates the matrix metalloproteinases MMP‐2 and MMP‐9 in limbic structures

Temporomandibular inflammation regulates the matrix metalloproteinases MMP‐2 and MMP‐9 in limbic structures

Activation of orexin‐1 receptors in the ventrolateral periaqueductal grey matter (vlPAG) modulates pulpal nociception and the induction of substance P in vlPAG and trigeminal nucleus caudalis

<p>Role of Dopaminergic Receptors Within the Ventral Tegmental Area in Antinociception Induced by Chemical Stimulation of the Lateral Hypothalamus in an Animal Model of Orofacial Pain</p>

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