Blockade of the Renin-Angiotensin System in Hypertensive Patients with Atherosclerotic Renal Artery Stenosis

Jarraya, F.; Pruijm, Menno; Wuerzner, Grégoire; Burnier, Michel

doi:10.1007/s11906-013-0376-x

Cited by 2 publications

(1 citation statement)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…48 Not surprisingly, modulation of the renin-angiotensin system with ACE-inhibitors or AT 1 R blockers, apart from its blood pressure lowering effect, improves and protects microvascular density, renal blood flow, and tubular function in kidneys with renal artery stenosis. 49,60 Renovascular hypertension due to fibromuscular dysplasia Although fibromuscular dysplasia is the second most common cause of renovascular hypertension (after atherosclerotic renal artery stenosis), pathophysiological mechanisms/changes in kidneys of patients with this disease have hardly been studied. Thus far, it was assumed that renal artery fibromuscular dysplasia causes hypertension due to a decrease in renal blood flow, followed by increased renin secretion, which on its turn increases blood pressure.…”

Section: Atherosclerotic Renal Artery Stenosismentioning

confidence: 99%

The renin-angiotensin system in the hypertensive kidney

Twist

View full text Add to dashboard Cite

People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. Link to publication General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal.If the publication is distributed under the terms of Article 25fa of the Dutch Copyright Act, indicated by the "Taverne" license above, please follow below link for the End User Agreement:

show abstract

Section: Atherosclerotic Renal Artery Stenosismentioning

confidence: 99%

The renin-angiotensin system in the hypertensive kidney

Twist

View full text Add to dashboard Cite

show abstract

Relationship between 24-h Ambulatory Blood Pressure Variability and Degree of Renal Artery Stenosis in Hospitalized Patients with Hypertension

Luo,

Liu,

Peng

et al. 2024

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Blood pressure variability (BPV) is a critical risk factor for cardiovascular outcomes and is associated with atherosclerotic renal artery stenosis (ARAS), which is diagnosed using digital subtraction angiography (DSA). However, the relationship between the degree of renal artery stenosis (d-RAS), diagnosed using renal artery contrast-enhanced ultrasound (CEUS), and 24-hour ambulatory BPV in hospitalized patients with ARAS remains unclear. Methods: Hospitalized hypertensive patients were divided into ARAS and non-ARAS groups based RAS diagnoses using CEUS. The ARAS patients were further classified into unilateral and bilateral categories. Quantification of BPV over 24 hours, daytime, and nighttime utilized standard deviation (SD), coefficient of variation (CV), and average real variability (ARV). Percentage stenosis was used to evaluate d-RAS. Pearson’s and multivariate beta regression analyses were used to assess correlations between BPV and d-RAS. Results: We found that 24-hour systolic BPV (SBPV), presented as SD, CV, and ARV indices, was positively correlated with unilateral d-RAS (R1 = 0.460, p = 0.001; R1 = 0.509, p < 0.001; R1 = 0.677, p < 0.001, respectively). This correlation was consistent with the daytime SBPV (R1 = 0.512, p < 0.001; R1 = 0.539, p < 0.001; R1 = 0.678, p < 0.001, respectively) and daytime diastolic BPV (DBPV) (R1 = 0.379, p = 0.010; R1 = 0.397, p = 0.007; R1 = 0.319, p = 0.033, respectively). Similarly, 24-hour DBPV assessed by SD and CV also correlated positively with unilateral d-RAS (R1 = 0.347, p = 0.019; R1 = 0.340, p = 0.022, respectively), as did nighttime SBPV assessed by ARV indices (R1 = 0.415, p = 0.005). No significant correlations were found between BPV and bilateral d-RAS (p > 0.05). Multivariate beta regression analysis indicated that 24-hour SBPV (odds ratio [OR] = 1.035, 95% confidence interval [CI]: 1.054–1.607, p = 0.035) and daytime SBPV (OR = 1.033, 95% CI: 1.004–1.061, p = 0.023; both evaluated via AVR) were independent risk factors for d-RAS. Conclusions: SBPV is positively correlated with unilateral d-RAS at all time points. Both 24-hour and daytime SBPV (evaluated using ARV indices) were identified as independent d-RAS risk factors.

show abstract

Blockade of the Renin-Angiotensin System in Hypertensive Patients with Atherosclerotic Renal Artery Stenosis

Cited by 2 publications

References 69 publications

The renin-angiotensin system in the hypertensive kidney

The renin-angiotensin system in the hypertensive kidney

Relationship between 24-h Ambulatory Blood Pressure Variability and Degree of Renal Artery Stenosis in Hospitalized Patients with Hypertension

Contact Info

Product

Resources

About