Blockage of metallothionein synthesis via adrenaline β receptor activation invalidates dehydroeffusol-mediated prevention of amyloid β1-42 toxicity

Tamano, Haruna; Takiguchi, Mako; Murakami, Daichi; Kawano, Yuya; Fukuda, Toshiyuki; Ikeda, Hiroki; Akagi, Yasuhito; Ikeura, Shinji; Takeda, Atsushi

doi:10.1016/j.neulet.2024.137708

Neuroscience Letters

2024

DOI: 10.1016/j.neulet.2024.137708

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Blockage of metallothionein synthesis via adrenaline β receptor activation invalidates dehydroeffusol-mediated prevention of amyloid β1-42 toxicity

Haruna Tamano,

Mako Takiguchi,

Daichi Murakami

et al.

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Insight into brain metallothioneins from bidirectional Zn2+ signaling in synaptic dynamics

Takeda,

Tamano

2024

Metallomics

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The basal levels as the labile Zn2+ pools in the extracellular and intracellular compartments are in the range of ∼10 nM and ∼100 pM, respectively. The influx of extracellular Zn2+ is used for memory via cognitive activity and is regulated for synaptic plasticity, a cellular mechanism of memory. When Zn2+ influx into neurons excessively occurs, however, it becomes a critical trigger for cognitive decline and neurodegeneration, resulting in acute and chronic pathogenesis. Aging, a biological process, generally accelerates vulnerability to neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). The basal level of extracellular Zn2+ is age relatedly increased in the rat hippocampus, and the influx of extracellular Zn2+ contributes to accelerating vulnerability to the AD and PD pathogenesis in experimental animals with aging. Metallothioneins (MTs) are Zn2+-binding proteins for cellular Zn2+ homeostasis and involved in not only supplying functional Zn2+ required for cognitive activity, but also capturing excess (toxic) Zn2+ involved in cognitive decline and neurodegeneration. Therefore, it is estimated that regulation of MT synthesis is involved in both neuronal activity and neuroprotection. The present report provides recent knowledge regarding the protective/preventive potential of MT synthesis against not only normal aging but also the AD and PD pathogenesis in experimental animals, focused on MT function in bidirectional Zn2+ signaling in synaptic dynamics.

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Insight into brain metallothioneins from bidirectional Zn2+ signaling in synaptic dynamics

Takeda,

Tamano

2024

Metallomics

View full text Add to dashboard Cite

show abstract

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Blockage of metallothionein synthesis via adrenaline β receptor activation invalidates dehydroeffusol-mediated prevention of amyloid β1-42 toxicity

Cited by 1 publication

References 30 publications

Insight into brain metallothioneins from bidirectional Zn2+ signaling in synaptic dynamics

Insight into brain metallothioneins from bidirectional Zn2+ signaling in synaptic dynamics

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