The emergence of construction 5.0 marks a shift toward a human-centric approach to digitization within the construction industry. Along with diverse digital innovations related to this shift, blockchain technology offers vast opportunities for the construction industry, including streamlining project management processes, enhancing transparency in payment processes, and improving contract administration. This paper systematically reviews 109 articles using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol to examine the applications of blockchain in construction, identifying twenty-three topics across eight thematic areas. These areas were further mapped using VOSviewer Online version 1.2.3 to identify interrelationships among the themes and highlight their broad impact. Key features like immutability, security, transparency, and traceability show promise in contract administration, supply chain logistics, facilities management, and sustainability. However, the study also describes the challenges of adopting blockchain in construction, emphasizing the need for enhanced stakeholder education, improved regulatory frameworks, and the creation of industry-specific blockchain platforms to support its acceptance in the construction industry. Emphasizing emerging blockchain applications and the adoption challenges equips researchers and practitioners with the knowledge of these applications and their significance to construction practices.