Clinical research evolved side-by-side with technology, leading to exponential data generation contributing to social and economic development. Nevertheless, data storage, integrity, and privacy concerns have emerged, raising trust issues regarding data sharing. This chapter will demonstrate how blockchain technology (BT) can address these problems and help optimizing processes, minimize costs, and monetize data. It will explain why these models are not fully explored and how cryptocurrencies are advantageous compared to traditional currency. Worldwide examples of companies developing network infrastructures that rely on private players will be provided, and European cases, where consortium models that count with different partners to build health blockchain infrastructures are being developed, will be discussed. Considering the business models to be addressed under the European Union (EU) jurisdiction, a hypothetical BT-based healthcare model with potential application in the EU scenario will also be highlighted.