Telemedicine has emerged as a transformative solution to bridge the healthcare gap in rural Africa, where access to medical services is often hindered by geographical remoteness and inadequate infrastructure. This paper delves into the current landscape of telemedicine in rural Africa, focusing on its accessibility and the profound impact it has on healthcare delivery. Accessibility remains a critical challenge in rural Africa, where vast distances and limited transportation infrastructure contribute to the isolation of many communities from healthcare facilities. Telemedicine, leveraging digital communication technologies, offers a promising avenue to overcome these barriers. The review examines the deployment of telemedicine infrastructure, including the availability of internet connectivity and the proliferation of mobile devices, as key factors influencing its accessibility in remote areas. Additionally, the study assesses the integration of telemedicine into existing healthcare systems, exploring the extent to which regulatory frameworks and policies support its implementation. The impact of telemedicine in rural Africa is multifaceted, encompassing improved healthcare access, enhanced diagnostic capabilities, and cost-effective interventions. The paper highlights how teleconsultations facilitate timely medical advice, reducing the need for patients to travel long distances for routine care. Moreover, the review scrutinizes the role of telemedicine in enabling remote diagnostic services, such as teleimaging and telepathology, which have proven instrumental in early disease detection and intervention. The socioeconomic impact of telemedicine is another dimension explored in this review. By alleviating the burden of healthcare-related travel expenses and reducing productivity losses due to illness, telemedicine contributes to the economic well-being of rural communities. The study investigates the potential of telemedicine to empower local healthcare workers through training programs, thereby enhancing the overall healthcare infrastructure in underserved regions. This review sheds light on the evolving landscape of telemedicine in rural Africa, emphasizing the critical need for improved accessibility and the far-reaching impact it has on healthcare delivery. As telemedicine continues to evolve, understanding its challenges and successes in the unique context of rural Africa will be instrumental in shaping effective strategies for the future.