Healthcare is a data-intensive domain, once a considerable volume of data is daily to monitoring patients, managing clinical research, producing medical records, and processing medical insurance claims. While the focus of applications of blockchain in practice has been to build distributed ledgers involving virtual tokens, the impetus of this emerging technology has now extended to the medical domain. With the increased popularity, it is crucial to study how this technology accompanied with a system for smart contracts can support and challenge the healthcare domain for all interrelated actors (patients, physicians, insurance companies, regulators) and involved assets (e.g. patients' data, physician's data, equipment's and drug's supply chain, etc.). The contributions of this paper are the following: (i) report the results of a systematic literature review conducted to identify, extract, evaluate and synthesize the studies on the symbiosis of blockchain in healthcare; (ii) summarize and categorize existing benefits/challenges on incorporating blockchain in healthcare domain; (iii) provide a framework that will facilitate new research activities; and (iv) establish the state of evidence with in-depth assessment.