In essence, the blockchain is a digital ledger with centralized, public, and decentralized records of executed transactions. One of the many features of blockchain technology is the interoperability capability that permit data to be exchanged between multiple systems and be considered simultaneously by multiple systems. Interoperability features in blockchain have the potential to significantly enhance outcomes in healthcare. In healthcare, blockchain researchers continue to explore how to bring innovation to this technology and how to make it interoperable. The purpose of this study is to present a systematic literature review (SLR) of research on healthcare blockchain interoperability. The researcher used the Preferred Reporting Items for Systematic Reviews guidelines, along with a systematic mapping study process, in which search protocols were used to identify, extract, and analyses all relevant publications across two scientific databases. The study highlights recent advances in the development of healthcare blockchain based on interoperability, their limitations, and the areas that require further research. Consequently, further research is needed to characterize and evaluate Blockchain interoperability in the healthcare sector.