The arising of the Cyber–Physical Systems’ vision and concepts drives technological evolution toward a new architectural design for the infrastructure of an environment referred to as a Smart Environment. This perspective alters the way systems within Smart City landscapes are conceived, designed, and ultimately realized. Modular architecture, resource-sharing techniques, and precise deployment approaches (such as microservices-oriented or reliant on the FaaS paradigm) serve as the cornerstones of a Smart City cognizant of multiple Cyber–Physical Systems composing it. This paper presents a framework integrating Digital Decisioning, encompassing the automated combination of human-derived knowledge and data-derived knowledge (e.g., business rules and machine learning), to enhance decision-making processes and application definition within the Smart City context.