Blocking of the effect of Δ1tetrahydrocannabinol (ΔTHC) on spontaneous motor activity in the rat by immunization with a protein conjugate of Δ1THC

Strahilevitz, Meir; Kelly, K.; Tsui, Paulus; Sehon, A.H.

doi:10.1016/0024-3205(74)90414-7

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The drug-recognizing antibodies sequester drug molecules in the blood stream, which reduces distribution to the brain, thereby reducing drug effects. To date vaccines have been shown to effectively attenuate effects of drugs such as cocaine (7–12), nicotine (13–21), morphine and heroin (22, 23), tetrahydrocannabinol (24) and phencyclidine (25, 26). Clinical studies of anti-cocaine and anti-nicotine vaccines are ongoing (27–29) and have shown titer-dependent efficacy during abstinence (28–31) as well as reduced subjective ratings of pleasurable drug effects (28).…”

Section: Introductionmentioning

confidence: 99%

A Methamphetamine Vaccine Attenuates Methamphetamine-Induced Disruptions in Thermoregulation and Activity in Rats

Miller

Moreno

Aarde

et al. 2013

Biological Psychiatry

View full text Add to dashboard Cite

Background There are no approved pharmacotherapies for d-methamphetamine (METH) addiction and existing therapies have limited efficacy. Advances in using immunotherapeutic approaches for cocaine and nicotine addiction have stimulated interest in creating a similar approach for METH addiction. This study investigated whether active vaccination against METH could potentially attenuate responses to METH, in vivo. Methods Male Sprague Dawley rats (N=32) received a 4-boost series with 1 of 3 candidate anti-METH vaccines (MH2(R), MH6, and MH7) or a control keyhole limpet hemocyanin conjugate vaccine (KLH). Effects of METH on rectal temperature and wheel activity at 27°C ambient temperature were determined. The most efficacious vaccine, MH6, was then contrasted with KLH in a subsequent experiment (N=16), wherein radiotelemetry determined home cage locomotor activity and body temperature at 23°C ambient temperature. Results The MH6 vaccine produced high antibody titers with nanomolar affinity for METH and sequestered METH in the periphery of rats. In Experiment 1, the thermoregulatory and psychomotor responses produced by METH at 27°C were blocked in the MH6 group. In Experiment 2, METH-induced decreases in body temperature and locomotor activity at 23°C were also attenuated in the MH6 group. A pharmacokinetic study in Experiment 2 showed that MH6-vaccinated rats had higher METH serum concentrations, yet lower brain METH concentrations than controls, and METH concentrations correlated with individual antibody titer. Conclusions These data demonstrate that active immunopharmacotherapy provides functional protection against physiological and behavioral disruptions induced by METH.

show abstract