Blocking prostanoid receptors switches on multiple immune responses and cascades of inflammatory signaling against larval stages in snail fever

Saber, Sameh; Alomar, Suliman Yousef; Yahya, Galal

doi:10.1007/s11356-022-20108-1

Cited by 5 publications

(2 citation statements)

References 82 publications

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“…The most important feature of activated immune cells is the production and release of growth factors and cytokines that modulate the inflammatory conditions [339][340][341][342][343][344][345][346]. Cancer-associated inflammation is a determining factor in disease progression and survival in CRC, contributing to invasion, tumor angiogenesis, and metastatic spread [347,348].…”

Section: Discussionmentioning

confidence: 99%

Interleukins (Cytokines) as Biomarkers in Colorectal Cancer: Progression, Detection, and Monitoring

Maryam

Krukiewicz

Haq

et al. 2023

JCM

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Cancer is the primary cause of death in economically developed countries and the second leading cause in developing countries. Colorectal cancer (CRC) is the third most common cause of cancer-related deaths worldwide. Risk factors for CRC include obesity, a diet low in fruits and vegetables, physical inactivity, and smoking. CRC has a poor prognosis, and there is a critical need for new diagnostic and prognostic biomarkers to reduce related deaths. Recently, studies have focused more on molecular testing to guide targeted treatments for CRC patients. The most crucial feature of activated immune cells is the production and release of growth factors and cytokines that modulate the inflammatory conditions in tumor tissues. The cytokine network is valuable for the prognosis and pathogenesis of colorectal cancer as they can aid in the cost-effective and non-invasive detection of cancer. A large number of interleukins (IL) released by the immune system at various stages of CRC can act as “biomarkers”. They play diverse functions in colorectal cancer, and include IL-4, IL-6, IL-8, IL-11, IL-17A, IL-22, IL-23, IL-33, TNF, TGF-β, and vascular endothelial growth factor (VEGF), which are pro-tumorigenic genes. However, there are an inadequate number of studies in this area considering its correlation with cytokine profiles that are clinically useful in diagnosing cancer. A better understanding of cytokine levels to establish diagnostic pathways entails an understanding of cytokine interactions and the regulation of their various biochemical signaling pathways in healthy individuals. This review provides a comprehensive summary of some interleukins as immunological biomarkers of CRC.

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Section: Discussionmentioning

confidence: 99%

Interleukins (Cytokines) as Biomarkers in Colorectal Cancer: Progression, Detection, and Monitoring

Maryam

Krukiewicz

Haq

et al. 2023

JCM

Self Cite

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“…These parasites, intricately entwined in their life cycles involving both freshwater snails and human hosts, contribute to the persistent dissemination of the disease. The excretion of parasite eggs in urine and feces by infected individuals perpetuates the cycle of transmission [76,77].…”

Section: Echinococcosismentioning

confidence: 99%

Emerging and Re-Emerging Parasitic Infections of the Central Nervous System (CNS) in Europe

Tunali,

Korkmaz

2023

Infectious Disease Reports

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In a rapidly evolving global landscape characterized by increased international travel, migration, and ecological shifts, this study sheds light on the emergence of protozoal and helminthic infections targeting the central nervous system (CNS) within Europe. Despite being traditionally associated with tropical regions, these infections are progressively becoming more prevalent in non-endemic areas. By scrutinizing the inherent risks, potential outcomes, and attendant challenges, this study underscores the intricate interplay between diagnostic limitations, susceptibility of specific population subsets, and the profound influence of climate fluctuations. The contemporary interconnectedness of societies serves as a conduit for introducing and establishing these infections, warranting comprehensive assessment. This study emphasizes the pivotal role of heightened clinician vigilance, judicious public health interventions, and synergistic research collaborations to mitigate the potential consequences of these infections. Though rare, their profound impact on morbidity and mortality underscores the collective urgency required to safeguard the neurological well-being of the European populace. Through this multifaceted approach, Europe can effectively navigate the complex terrain posed with these emergent infections.

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Artemisia Species and Their Active Constituents for Treating Schistosomiasis

Taljaard

Haynes

Kooy

2023

Rev. Bras. Farmacogn.

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Schistosomiasis, a neglected tropical disease, affects millions of lives and accounts for thousands of deaths each year. The Schistosoma parasites depend on two hosts during their lifecycle: snails as intermediate hosts and human beings as definitive hosts. Therefore, to control and ultimately eliminate schistosomiasis relies on the reduction of snail populations as well as the prevention and treatment of schistosomiasis infections. Praziquantel is the primary drug for prevention and treatment, and although it is considered safe and efficacious, concerns exist regarding emerging drug resistance due to mass drug administration. For this reason, novel antischistosomal drugs are in need and the genus Artemisia might be a promising source. Notably, Artemisia species not only have been evaluated for their antischistosomal effects against Schistosoma parasites, but also for their molluscicidal effects against the snail vectors. Extracts of Artemisia afra seem to be the most active, with IC50 values comparable with the positive control, praziquantel. The antimalarial drug artemisinin, obtained from A. annua, and its semisynthetic derivatives artemether, artesunate, and artemisone have also been evaluated against both schistosomes and snail vectors. Artemether and artesunate have been found to be notably active against the adult and juvenile stages of schistosomes, whereas artemisone was shown to be effective in treating hosts harboring juvenile schistosomes. Artemisinin on the other hand in combination with praziquantel presents as a good lead combination in curing schistosomiasis. Graphical Abstract

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Blocking prostanoid receptors switches on multiple immune responses and cascades of inflammatory signaling against larval stages in snail fever

Cited by 5 publications

References 82 publications

Interleukins (Cytokines) as Biomarkers in Colorectal Cancer: Progression, Detection, and Monitoring

Interleukins (Cytokines) as Biomarkers in Colorectal Cancer: Progression, Detection, and Monitoring

Emerging and Re-Emerging Parasitic Infections of the Central Nervous System (CNS) in Europe

Artemisia Species and Their Active Constituents for Treating Schistosomiasis

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