Recent satellite inferences of hydrous sulfates as recurrent minerals on the surface of icy planetary bodies link with the potential mineral composition of their interior. Blödite, a mixed Mg-Na sulfate, is here taken as mineral representative of icy satellites surface to investigate its crystal structure and stability at conditions of the interior of icy bodies. To this aim we performed in situ synchrotron angle-dispersive X-ray powder diffraction experiments on natural blödite at pressures up to ~10 GPa and temperatures from ~100 K to ~570 K using diamond anvil cell technique to investigate the compression behavior and establish a low-to-high temperature equation of state that can be used as reference when modelling the interior of sulfate-rich icy satellites such as Ganymede.The experimentally determined volume expansivity, , varies from 7.6 (6) 10 -5 K -1 at 0.0001 GPa (from 199 to 413 K) to 2.6 (3) 10 -5 K -1 at 10 GPa (from 293 to 453 K) with aδ/δP coefficient = -5.6(8)10 -6 GPa -1 K -1 .The bulk modulus calculated from the least squares fitting of P-V data on the isotherm at 413 K using a second-order Birch -Murnaghan equation of state is 38 GPa, which gives the value of K/δT equal to 0.01(5) GPa -1 K -1 . The thermobaric behavior of blödite appears strongly anisotropic with c lattice parameter being more deformed with respect to a and b.Thermogravimetric analyses performed at ambient pressure showed three endotherms at 410 K, 500 K and 1000 K, with weight losses of approximately 11%, 11% and 43% caused by partial dehydration, full dehydration and sulfate decomposition. Interestingly, no clear evidence of dehydration was observed up to ~470 K and ~10 GPa, suggesting that pressure would act to stabilize the crystalline structure of blödite.The data collected allow to write the following equation of state, V(P,T) = V 0 [ 1+ 7.6(6) 10 -5 Δ T -0.026(3)P -5.6(8) 10 -6 PΔT -6.6(9) 10 -6 PT ) from which the density of blödite can be determined at conditions of the ice mantle of the large icy satellites of Jupiter. Based on current thermal models for the interior of Ganymede, for instance, blödite is predicted to remain stable with the density almost unchanged to about 1000 km in depth in equilibrium with a deep saline ocean.Blödite has higher density, bulk modulus and thermal stability than similar hydrous sulfates (e.g. mirabilite and epsomite) implying, therefore, a different contribution of these minerals to the extent of deep oceans in icy planets and their distribution over the local geotherms Keywords Blödite, high pressure, icy satellite, sulfate, in situ angle-dispersive X-ray diffraction, synchrotron. V between 119 and 433 K of 7.6 (7)10 -5 K -1 .The c lattice parameter remains the most deformable with respect to a and b that, therefore, show very similar thermal expansion values. Because the monoclinic symmetry of blödite with β angle significantly different from 90°, the principal directions of the expansion tensor should be investigated. The symmetry requires a direction parallel to b axis, and ...