Blond and blood juice supplementation in high fat diet fed mice: effect on antioxidant status and DDAH/ADMA pathway

Sorrenti, Valeria; Giacomo, Claudia Di; Acquaviva, Rosaria; Cosenza, Jennifer; Carota, Giuseppe; Galvano, Fabio

doi:10.1039/c9ra00669a

Cited by 3 publications

(2 citation statements)

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“…NASH, in turn, can lead to cirrhosis or to related complications, such as hepatocellular carcinoma. However, it is possible to prevent or even reverse fatty liver disease with lifestyle changes [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the by-products and the waste which comes from processing red oranges and olive leaves are particularly rich in bioactive compounds such as a) anthocyanins, flavanones and hydroxycinnamic acids, and b) oleuropein, elenolic acid, hydroxytyrosol, tyrosol and rutin, respectively, and have numerous nutraceutical properties such as the ability to control blood pressure, blood sugar content, triglyceride and cholesterol levels and so on [ 6 , 7 , 8 , 9 , 10 , 11 ]. So, the preparation of natural extracts may represent a way to use the waste and by-products of agricultural production by giving orange processing factories and the olive industry new possibilities that allow them to increase the added value of their production [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Beneficial Effects of Standardized Extracts from Wastes of Red Oranges and Olive Leaves

Burò

Consoli

Castellano³

et al. 2022

Antioxidants

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The awareness of the large amount of waste produced along the food chain, starting in the agricultural sector and continuing across industrial transformation to the domestic context, has in recent years also aroused strong concern amongst the public, who are ing about the possible consequences that this could have on environmental sustainability, resource waste and human health. The aim of the present research is the recovery of substances with high added value from waste and by-products typical of the Mediterranean area, such as the residue from the industrial processing of red oranges, called pastazzo (peels, pulps and seeds), which is particularly rich in anthocyanins, flavanones and hydroxycinnamic acids, and has numerous nutraceutical properties, as well as the olive leaves coming from olive-tree pruning, which are rich in substances such as oleuropein, elenolic acid, hydroxytyrosol, tyrosol and rutin. The effect of Red Orange Extract (ROE) and Olive Leaf Extract (OLE) on HepG2 fatty storage capacity was assessed performing Oil Red O’ staining, and antioxidant properties of the extracts were evaluated following the steatosis model onset. Based on the results obtained, the preparation of natural extracts that are derived from these waste products can be useful for preventing, counteracting or delaying the onset of the complications of fatty liver disease, such as hepatic steatosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Standardized Extracts from Wastes of Red Oranges and Olive Leaves

Burò

Consoli

Castellano³

et al. 2022

Antioxidants

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Beverages and Non-alcoholic fatty liver disease (NAFLD): Think before you drink

2021

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Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial

Notarnicola,

Tutino,

De Nunzio

et al. 2024

Nutrients

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Background: Consumption of flavonoid-rich orange juice has been shown to reduce adiposity and liver steatosis in murine models of diet-induced obesity. However, little is known about the effects of whole orange intake, independent of body weight changes, on liver function and steatosis in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). The goal is to understand the direct impact of orange consumption on metabolic health. Methods: Sixty-two men and women aged 30–65 with MASLD (Controlled Attenuation Parameter, (CAP) > 275 dB/m) were randomly assigned to consume either 400 g of whole oranges or non-citrus fruits daily for 4 weeks. Baseline evaluations included medical assessments, blood tests, and body composition. Liver health was assessed using transient elastography (FibroScan®) for steatosis and fibrosis, conducted by blinded personnel. This clinical trial was registered at ClinicalTrials.gov (NCT05558592). Results: After 4 weeks of orange supplementation, liver steatosis decreased in the treatment group, with 70.9% showing steatosis compared to 100% in controls (p < 0.004), indicating a 30% reduction in liver disease prevalence. There were no significant changes in fibrosis or plasma liver enzymes, though plasma gamma glutaril transferase (GGT) levels decreased significantly. Body weight, waist circumference, body composition, lipid profile, fasting glucose, insulin, and C-reactive protein levels remained unchanged. Dietary analysis revealed no change in caloric intake, but vitamins C, A, thiamine, and riboflavin increased in the orange group. Conclusions: Our findings suggest that phytochemical-rich foods, especially whole fruits like oranges, may enhance liver function as an adjunct treatment for MASLD. The notable reduction in liver steatosis prevalence occurred independently of body weight changes. Further studies are needed to investigate the long-term effects of orange supplementation on steatosis and fibrosis progression and to identify the specific bioactive compounds and mechanisms involved.

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Blond and blood juice supplementation in high fat diet fed mice: effect on antioxidant status and DDAH/ADMA pathway

Abstract: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease spread throughout the world.

Cited by 3 publications

References 37 publications

Beneficial Effects of Standardized Extracts from Wastes of Red Oranges and Olive Leaves

Beneficial Effects of Standardized Extracts from Wastes of Red Oranges and Olive Leaves

Beverages and Non-alcoholic fatty liver disease (NAFLD): Think before you drink

Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial

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