Blood alcohol level and caloric intake in the gravid rat as a function of diurnal period, trimester, and vehicle

Martin, Joan C.; Martin, Donald C.; Radow, Barbara; Sigman, Gary

doi:10.1016/0091-3057(78)90080-1

Cited by 12 publications

(1 citation statement)

References 17 publications

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“…It has been reported that maternal malnutrition increases (Testar et al, 1986), has no effect (Goad et al, 1984), or even decreases (Ribeiro-da-Silva et al, 1994) the embryo-fetal developmental disturbances caused by ethanol in the offspring. Studies of ethanol-exposed pregnancy where a pair-fed group has been included to compensate for a (postulated) dietary restriction of the mother have not reported increased somatic malformation rate (Catlin et al, 1993;Goad et al, 1984) or other types of developmental damage (Henderson et al, 1995;Inselman et al, 1985;Martin et al, 1978;Miller and Dow-Edwards, 1988;Polache et al, 1996;Seyoum and Persaud, 1997;Zhou et al, 2001) in the pair-fed group; however, some of the studies have found decreased body weight of the offspring (Goad et al, 1984;Middaugh et al, 1988;Ribeiro-da-Silva et al, 1994;Testar et al, 1986). Therefore, the growth retardation, but not the malformations, of the offspring may be partly associated with a maternal nutritional imbalance in our study.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative Treatment Diminishes Ethanol‐Induced Congenital Malformations in the Rat

Wentzel

Rydberg

Eriksson

2006

Alcoholism Clin & Exp Res

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Section: Discussionmentioning

confidence: 99%

Antioxidative Treatment Diminishes Ethanol‐Induced Congenital Malformations in the Rat

Wentzel

Rydberg

Eriksson

2006

Alcoholism Clin & Exp Res

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Cardiac muscle development in mice exposed to ethanol in utero

1984

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The purpose of the present research was to determine the effect of in utero ethanol exposure on cardiac muscle development. Pregnant albino mice (Swiss strain) at 8 days of gestation were divided into three groups: a normal group fed Purina lab chow for rodents and water ad libitum; an ethanol group fed the liquid diet ENSURE with 20% of the calories derived from ethanol (12.6 +/- 1.2 gm/kg body weight per day); and an isocaloric group pairfed ENSURE with 20% of the calories derived from sucrose. These diets were continued until birth, at which time the litter size, crown to rump length, and weight were recorded. Randomly selected neonatal pups from each litter were decapitated and their hearts immediately processed for transmission electron microscopy. Litter size, crown to rump length, and body weight of the ethanol-treated mice at birth were significantly less than normal but not less than pairfed controls. Ultrastructural evaluation of cardiac muscle from mice treated in utero with ethanol in comparison to that from both normal and pair-fed control animals revealed various degrees of morphological alterations. The most pronounced alterations were in mitochondrial structure and included an increase in mitochondrial volume per cytoplasmic volume and a marked decrease in the amount of inner mitochondrial membrane. Myofibrillar abnormalities were also evident in the ethanol group but not in either control group. These abnormalities included a decrease in the myofibril volume per cytoplasmic volume and a disruption in myofibril organization particularly the Z-bands. The ultrastructural alterations in the cardiac muscle from the ethanol treated group were not a result of malnutrition or dehydration as the pairfed group did not exhibit these changes. It is apparent from this study that exposure of mice in utero to ethanol can cause ultrastructural abnormalities in cardiac muscle cells. Whether these changes result in heart pathophysiology and persist to adulthood are not known.

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Prenatal Effects of Alcohol Abuse in Humans and Laboratory Animals

Streissguth

Martin

1983

The Biology of Alcoholism

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Blood alcohol level and caloric intake in the gravid rat as a function of diurnal period, trimester, and vehicle

Cited by 12 publications

References 17 publications

Antioxidative Treatment Diminishes Ethanol‐Induced Congenital Malformations in the Rat

Antioxidative Treatment Diminishes Ethanol‐Induced Congenital Malformations in the Rat

Cardiac muscle development in mice exposed to ethanol in utero

Prenatal Effects of Alcohol Abuse in Humans and Laboratory Animals

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