Blood Alcohol Level Discrimination

Lipscomb, Thomas R.; Nathan, Peter E.

doi:10.1001/archpsyc.1980.01780180085010

Cited by 80 publications

(8 citation statements)

References 23 publications

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“…Together with previous results, our study suggests that FHP individuals may not detect their growing level of intoxication compared to FHN. This is compatible with prior data on drinking behavior in FHP (Lipscomb and Nathan 1980; Lansky et al 1978). However, our results also indicate that FHN individuals are more vulnerable to impair-mentin Go/No-Go performance evenbylow levels ofNMDA receptor blockade—suggesting that they may be more likely to have problems with driving and other critical aspects of behavioral control at modest levels of intoxication.…”

Section: Discussionsupporting

confidence: 91%

Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism

et al. 2012

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Rationale Individuals with a family history of alcoholism (family history positive [FHP]) show higher alcoholism rates and are more impulsive than those without such a family history (family history negative [FHN]), possibly due to altered N-methyl-D-aspartate (NMDA) receptor function. Objectives We investigated whether memantine, an NMDA receptor antagonist, differentially influences impulsivity measures and Go/No-Go behavior and fMRI activity in matched FHP and FHN individuals. Methods On separate days, participants received a single dose of 40 mg memantine or identical-appearing placebo. Results No group performance differences were observed on placebo for Go correct hit or No-Go false alarm reaction time on the Go/No-Go task. During fMRI, right cingulate activation differed for FHP vs. FHN subjects during No-Go correct rejects. Memantine had attenuated effects in FHP vs. FHN subjects: For No-Go false alarms, memantine was associated with limited reduction in subcortical, cingulate, and temporal regions in FHP subjects and reduced activity in fronto-striatal–parietal networks in FHN subjects. For No-Go correct rejects, memantine (relative to placebo) reduced activity in left cingulate and caudate in FHP but not FHN subjects. Conclusions Lower sensitivity to the effects of memantine in FHP subjects is consistent with greater NMDA receptor function in this group.

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Section: Discussionsupporting

confidence: 91%

Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism

et al. 2012

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“…This upregulation in NMDA-R function might increase the risk for heavy drinking by decreasing unpleasant effects of ethanol and reducing cues that normally serve to help people regulate their drinking (Krystal et al, 2003a). The latter part of this hypothesis is consistent with evidence that individuals tolerant to ethanol have difficulty accurately estimating their blood alcohol level, even when trained to do so (Lipscomb and Nathan, 1980). …”

supporting

confidence: 86%

NMDA Glutamate Receptor Antagonism and the Heritable Risk for Alcoholism: New Insights from a Study of Nitrous Oxide

Krystal

Petrakis

O’Malley

et al. 2017

International Journal of Neuropsychopharmacology

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“…In addition, O'Malley & Maisto found that variation in BAC was a weaker predictor of self-perceived intoxication for FHP subjects than for FHN subjects. Contrary to the above findings, however, a study by Lipscomb & Nathan (1980) found no FHP-FHN differences in subjects' abilities to gauge their blood alcohol levels after various doses of alcohol.…”

Section: Introductioncontrasting

confidence: 69%

Adult Children of Alcoholics: cognitive and psychomotor characteristics

Wilson

Nagoshi

1988

British Journal of Addiction

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A comparison of individuals who report alcohol abuse in one or both parents (family history positive: FHP) with those who do not (family history negative: FHN) on a number of metabolic, behavioral, and mood measures before and after alcohol dosing revealed marginally lower cognitive abilities, on average, in the FHP group. Most of the other hypothesized differences between groups (e.g. alcohol metabolism; differential alcohol sensitivity, differential alcohol tolerance; mood) were not found, except in two-and three-way interactions among gender, age, and FH. It seems evident that the search for biological markers of increased risk for future alcohol abuse will need to take account of gender and age, in addition to familial alcohol abuse.

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Blood Alcohol Level Discrimination

Cited by 80 publications

References 23 publications

Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism

Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism

NMDA Glutamate Receptor Antagonism and the Heritable Risk for Alcoholism: New Insights from a Study of Nitrous Oxide

Adult Children of Alcoholics: cognitive and psychomotor characteristics

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