Blood Ammonia, Experimental and Clinical Study in Abnormalities of the Liver and Portal Circulation

Mann, Joseph D.; Bollman, Jesse L.; Huizenga, Kenneth A.; Farrar, T; Grindlay, John H.

doi:10.1016/s0016-5085(19)36122-0

Cited by 33 publications

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“…A well known clinical syndrome observed in some liver diseases, and in the conditions of portacaval shunt, is considered due to ammonia intoxication (4).…”

Section: T -mentioning

confidence: 99%

Effect of Ethionine on Total Blood Ammonia in Rats.

Kowalewski

1965

Experimental Biology and Medicine

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486RATS' BLOOD AMMONIA AFTER ETHIONINE centration of 0.1 mg% without a complete loss of inhibitory effect.Of a series of anions tested for antibacterial activity in the presence of dialyzed saliva, only iodide was effective in addition to thiocyanate(6,7). Fig. 2 confirms the antibacterial effect of iodide in the presence of dialyzed saliva and also demonstrates the antibacterial effect of iodide in the presence of an amount of lactoperoxidase equivalent to the amount present in 0.5 ml of saliva. The amount of iodide employed (250 pg per tube) was considerably in excess of the amount present in 0.5 ml of saliva (0.02-0.12 p g taking a range in saliva of 0.0035-0.024 mgJlOO ml (7)). No effect of iodide was observed at a concentration equivalent to that of saliva.The mechanism of the inhibition of lactobacillus growth by saliva is unknown. Thiocyanate is oxidized by peroxidase and H2O2 and the relationship of thiocyanate oxidation to microbial growth inhibition is under investigation. The demonstration that myeloperoxidase can substitute for lactoperoxidase in the antilactobacillus system suggests the possibility that myeloperoxidase present in leucocytes might exert an antibacterial effect by a mechanism similar to that reported here.Summary. It has been previously reported by others that the growth of lactobacillus in complete growth medium is inhibited by saliva and that a component of the antilactobacillus system of saliva is thiocyanate ion. The inhibition of growth of lactobacillus by saliva i s decreased by catalase, The heat labile non-dialyzable component of the antilactobacillus system of saliva can be replaced by an amount of lactoperoxidase equivalent to the amount present in saliva. This suggests that the antilactobacillus system of saliva contains at least two components, peroxidase and thiocyanate ions. Iodide at a concentration in excess of that present in saliva can replace thiocyanate in this system.The excellent technical assistance of Mrs. Aline Alenty and Mrs. Ann Waltersdorph is very gratefully acknowledged.

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“…A well known clinical syndrome observed in some liver diseases, and in the conditions of portacaval shunt, is considered due to ammonia intoxication (4).…”

Section: T -mentioning

confidence: 99%