Blood and Extracellular Fluid Volume in Patients With Bartter's Syndrome

Boer, P. de

doi:10.1001/archinte.1983.00350100064017

Cited by 45 publications

(25 citation statements)

References 31 publications

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“…PRA (expressed as femtomoles of angiotensin I [Ang I] per liter per second) and plasma aldosterone were determined by 'radjoimmunoassay. 16 ANF was extracted from 2.5 ml of plasma by reverse-phase chromatography using Baker butyl wide-pore extraction columns (Phillipsburg, NJ, USA), followed by elution with methanol/glacial acetic acid (49:1 vol/vol; recovery of ANF, 62%). After evaporation, the extract was dissolved in radioimmunoassay buffer and aliquots were used for determination by radioimmunoassay using an antibody of Peninsula Laboratories (Merseyside, UK) according to the manufacturer's instructions.…”

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confidence: 99%

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Enalapril attenuates natriuresis of atrial natriuretic factor in humans.

Gaillard¹,

Koomans²,

Mees³

1988

Hypertension

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. Under these conditions baseline sodium excretion was not different from the control study, but it rose less after ANF (from 117 ± 22 to 242 ± 63 /umol/min), and the increments in glomerular nitration rate, free water clearance, phosphate, lithium, uric add, and magnesium were all blunted and nonsignificant. In addition, effective renal plasma flow tended to fall; this effect was not observed when ANF was given without enalapril. These results support the notion that the effects of ANF on renal hemodynamics and on tubular sodium handling depend on renal angiotensln II and that blood pressure reduction may interfere with the ANF-induced natriuresis. (Hypertension 11:160-165,1988)

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confidence: 99%

“…27 ' 32 This would leave unexplained the increased excretion after administration of ANF of lithium, phosphate, and uric acid, alleged indicators of proximal tubular sodium reabsorption. 16 …”

mentioning

confidence: 99%

Enalapril attenuates natriuresis of atrial natriuretic factor in humans.

Gaillard¹,

Koomans²,

Mees³

1988

Hypertension

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“…Undiluted plasma was incubated for 1 h at 37°C and pH 5.6 in the presence of phenylmethylsulfonylfluoride and 8-hydroxyquinoline, deproteinized with 3 volumes of a 9:1 mix of acetone/4 N ammonia 9: 1, dried under air stream, and dissolved in PRA buffer. PA was assessed by a nonchromatographic direct radioimmunoassay after extraction from 2 ml plasma with dichlormethane (Boer et al, 1983). NA and Ad were measured by a radio-enzymatic technique (Peuler & Johnson, 1977 bodyweight, MAP, log PRA, and log PA were calculated from the data of both studies.…”

Section: Methodsmentioning

confidence: 99%

Influence of nicardipine on blood pressure, renal function and plasma aldosterone in normotensive volunteers.

Schaik¹,

Hené²,

Geyskes³

1985

Brit J Clinical Pharma

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1 The influence of the calcium antagonist nicardipine on intrarenal sodium handling and angiotensin II induced secretion of aldosterone was investigated in 18 normotensive volunteers after the first dose and after 1 week of treatment (20 mg three times daily). 2 A short-lasting natriuresis was observed, which was caused by a decreased reabsorption of sodium localised in both proximal and distal tubules. 3 Log plasma renin activity (PRA) fell significantly on each day during angiotensin II infusion, while log plasma aldosterone (PA) rose significantly. 4 The log PRA/log PA ratio was increased during nicardipine treatment. The secretion of aldosterone, induced by angiotensin II, was not influenced by nicardipine treatment. No effect of the drug on adrenal responsiveness to angiotensin II was found.

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“…Aldosterone was extracted from 1 ml plasma with dichloromethane. The extract was evaporated, redissolved in assay buffer, and aldosterone was quantitated by RIA (ICN Pharmaceuticals Inc., Costa Mesa, CA) [19].…”

Section: Hormone Determinationsmentioning

confidence: 99%

Na+, K+-ATPase content in skeletal muscle of dogs with pituitary-dependent hyperadrenocorticism

Schotanus

Meij

Vos

et al. 2006

Domestic Animal Endocrinology

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Several hormones regulate Na + , K + -ATPase content in the muscle cell membrane, which is essential for maintaining muscle cell excitability. Chronic glucocorticoid excess is associated with muscle weakness and reduced endurance. We hypothesized that chronic glucocorticoid excess affects Na + , K + -ATPase content in canine skeletal muscle, and contributes to reduced endurance and muscle weakness associated with pituitary-dependent hyperadrenocorticism (PDH) in dogs. Therefore, Na + , K + -ATPase content in skeletal muscle was evaluated before and after hypophysectomy and hormone replacement (cortisone and l-thyroxin) in dogs with PDH (n = 13), and in healthy controls (n = 6). In addition, baseline and exercise-induced changes in plasma electrolyte concentrations and acid-base balance were evaluated before and after hypophysectomy in dogs with PDH. Na + , K + -ATPase content of gluteal muscle in dogs with PDH was significantly lower than in control dogs (201 ± 13 pmol/g versus 260 ± 8 pmol/g wet weight; P < 0.01). Similar differences were found in palatine muscle. After hypophysectomy and on hormone replacement, Na + , K + -ATPase was increased (234 ± 7 pmol/g wet weight). Both plasma pH and base excess in dogs with PDH (7.44 ± 0.01; 1.7 ± 0.6 mmol/l, respectively) were significantly higher (P < 0.05) than after hypophysectomy and hormone replacement (7.41 ± 0.01; −0.2 ± 0.4 mmol/l, respectively). Exercise induced respiratory alkalosis, but did not result in hyperkalemia in dogs with PDH. In conclusion, chronic glucocorticoid excess in dogs with PDH is associated with decreased Na + , K + -ATPase content in skeletal muscle. This may contribute to reduce endurance in canine PDH, although dogs with PDH did not exhibit exercise-induced hyper- * Corresponding author.

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Blood and Extracellular Fluid Volume in Patients With Bartter's Syndrome

Cited by 45 publications

References 31 publications

Enalapril attenuates natriuresis of atrial natriuretic factor in humans.

Enalapril attenuates natriuresis of atrial natriuretic factor in humans.

Influence of nicardipine on blood pressure, renal function and plasma aldosterone in normotensive volunteers.

Na+, K+-ATPase content in skeletal muscle of dogs with pituitary-dependent hyperadrenocorticism

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