Blood and Urinary Aggregator and Inhibitor Composition in Controls and Renal-Stone Patients from Northeastern Thailand

Abstract

Renal-stone disease (RSD) is common in the rural communities of northeastern Thailand. We report the biochemical composition of blood and urine in 25 healthy city dwellers (Gl), 12 healthy village dwellers (G2) and 25 village dwellers who had RSD (G3). They were male with a range of ages between 20 and 50 years and were free of renal failure, urinary infection, urinary obstruction and systemic illness. The results showed that hypocitraturia, hypokalemia and hypokaliuria were more common in the latter 2 groups. The 24-h urinary citrate excretion correlated significantly with urinary potassium in G3 cases (r = 0.704, p = 0.0002). After potassium chloride supplementation, serum and urinary potassium increased remarkably (p < 0.003 and p = 0.002, respectively), whereas urinary citrate remained unchanged. Our results suggest that the predominant abnormality in our RSD patients were hypocitraturia and potassium deficiency and that these may be related.

Hypokalemia, High Erythrocyte Na⁺ and Low Erythrocyte NaK-ATPase in Relatives of Patients Dying from Sudden Unexplained Death Syndrome in North-East Thailand and in Survivors from Near-Fatal Attacks

“…It could be found among healthy rural dwellers, renal stone formers [9] and patients with distal renal tubular acidosis [22]. Hypokalemia and low urinary potassium excretion can be corrected with potassium supplementation suggesting that there was potassium deficiency [10], The mechanism of potassium depletion is not fully understood and might be multifactorial. The dietary potassium intake of NorthEast Thais can be as low as 20-25 mmol/dav [Puwasatien et al, pers.…”

“…These hypotheses are, however, difficult to prove when the subjects are still alive since SUDS is a retrospective diagnosis. We have pre viously reported that hypokalemia and low urinary potas sium are common in healthy rural males from North-East Thailand [10]. Moreover, this population group also had lower activity of erythrocyte membrane Na,K-ATPase and higher erythrocyte sodium (RBCNa) than Thais from other regions of the country [11], Since SUDS victims from North-East Thailand are healthy prior to death, they might have similar metabolic abnormalities.…”

Urinary lithogenic and inhibitory factors in preterm neonates receiving either total parenteral nutrition or milk formula

“…Furosemide is reported to affect renal excretion of several ions such as sodium, potassium, magnesium, which in turn may affect citrate excretion [22,27,33]. A study with non-furosemide treated infants demonstrated differences in urinary excretion of the above minerals that could be attributed to the different type of feeding.…”

Is There a Relationship between Citraturia and Kaliuria among Stone Formers?

“…Dear Sir, Sriboonlue et al [ 1 ] have found a relation ship between citraturia and kaliuria among stone formers. Their patients were village dwellers whose urinary and blood analysis show ed a potassium deficiency co m p ared to nonstone formers living in a large city.…”

“…Cotransport was stimulated and citrate reabsorption was increased with hypo citraturia. Sriboonlue et al [1] said excessive sweat and dietary factors could be the cause of potassium depletion. They administered potassium chloride to their patients and ob tained a correction of potassium depletion without hypocitraturia modification.…”