Blood and urinary ketoacids in indian childhood cirrhosis

Dhatt, P. S.; Gupta, Harish; Saini, A. S.

doi:10.1007/bf02756291

Cited by 1 publication

(6 citation statements)

References 13 publications

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“…Dhatt et al studied serum glutamine levels in children with Indian childhood cirrhosis (ICC) and reported no significant differences in average serum glutamine in patients with ICC and HE compared to patients with ICC and no HE (13 ± 3.8 vs 12.9 ± 3.76 mg/mL, P >.05). However, glutamine levels were higher in both ICC with and without HE when compared to healthy controls (ICC and HE: 13 ± 3.8 vs 8.8 ± 2.4 mg/mL, P < 0.05; ICC without HE: 12.9 ± 3.76 vs 8.8 ± 2.4 mg/mL, P < 0.05), suggesting glutamine elevation was attributed to ICC, rather than HE (32).…”

Section: Resultsmentioning

confidence: 91%

“…Study content is summarized in Table 1. The studies included 6 pediatric and 9 mixed cohorts (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). Patients in these studies were categorized as either MHE or HE and were compared to controls with and without liver disease.…”

Section: Resultsmentioning

confidence: 99%

“…Serum biomarkers and observed associations with HE or MHE are summarized in Table 2 (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). IL-6 and TNF-alpha were the most frequently studied biomarkers, with all remaining markers evaluated in 2 or fewer studies.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies (32,33) observed glutamine in various liver pathologies. Dhatt et al studied serum glutamine levels in children with Indian childhood cirrhosis (ICC) and reported no significant differences in average serum glutamine in patients with ICC and HE compared to patients with ICC and no HE (13 ± 3.8 vs 12.9 ± 3.76 mg/mL, P >.05).…”

Section: Resultsmentioning

confidence: 99%

“…Two independent reviewers screened remaining abstracts, and subsequently 115 full texts, for final inclusion and data extraction (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). A third author, who did not participate in the initial review of each article, adjudicated any discordant screening results.…”

Section: Selection and Screeningmentioning

confidence: 99%

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Novel Serum Biomarkers Associated With Pediatric Hepatic Encephalopathy: A Systematic Review

Krishnan

Rao

Chang

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Background:The pathophysiology of pediatric hepatic encephalopathy (HE) is not well understood. Various serum biomarkers associated with HE may provide insight into its pathology, but their use and interpretation in clinical practice for diagnosis and prognostication remain undetermined. We sought to investigate reported correlations of serum biomarkers with presence and degree of HE in children. Methods: We conducted a systematic review of studies examining novel serum biomarkers and cytokines in association with HE that included children on PubMed, Embase, Lilacs, and Scopus. We utilized Covidence for abstract and text review by 2 independent reviewers for each study. Results: We reviewed 2824 unique publications; 15 met criteria for inclusion. Categories of biomarkers reported were inflammatory cytokines, products of amino acid metabolism, trace elements and vitamins, and hepatic and neuro biomarkers. Of 19 individual biomarkers, only 5 were measured in more than 1 study. Elevations in interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were most commonly reported as associated with HE. Notably, we observed lower average IL-6 and TNF-alpha levels in pediatric-only studies compared to mixed age studies. Overall, high bias and poor applicability to our review question was observed. We encountered low numbers of studies with pediatric focus, and few conducted with low bias study designs. Conclusion: Investigated biomarkers span a large range of categories and suggest potentially useful correlations with HE. Further well-designed prospective biomarker research is necessary to better elucidate the pathogenesis of HE in children and improve early detection and clinical care.

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Section: Resultsmentioning

confidence: 91%