Blood arsenic levels and the risk of familial breast cancer in Poland

Marciniak, Wojciech; Derkacz, Róża; Muszyńska, Magdalena; Baszuk, Piotr; Gronwald, Jacek; Huzarski, Tomasz; Cybulski, Cezary; Jakubowska, Anna; Falco, Michał; Dębniak, Tadeusz; Lener, Marcin; Oszurek, Oleg; Pullella, Katherine; Kotsopoulos, Joanne; Park, Sun; Narod, Steven A.; Lubiński, Jan

doi:10.1002/ijc.32595

Cited by 32 publications

(19 citation statements)

References 47 publications

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“…Previously, very high arsenic concentration in the blood samples of the cancer patients was reported by. 26,35 The hair and the toenail samples relatively had very high arsenic concentration in hair samples (1296•9μg/Kg) while in toenail samples, as high as 621•83μg/Kg was recorded. This was signi cantly higher than the control samples.…”

Section: Discussionmentioning

confidence: 99%

“…46 At the genetic level, mutations in CHEK2, PALB2, NBN, BRCA1 and other susceptible genes have been found to be mutated due to metal toxicity. [47][48][49] Marciniak et al, (2020), 35 have evaluated the arsenic exposure with 13 folds risk of breast cancer in the exposed population. The study also correlates the blood arsenic levels with the breast cancer risk in women.…”

Section: Discussionmentioning

confidence: 99%

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Arsenic Induced Breast Cancer Risk in Population of Bihar, India

Kumar¹,

Ali²,

Niraj³

et al. 2021

Preprint

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Globally, ~ 300 million people are exposed to arsenic poisoning while in India an estimated 70 million people are affected by consumption of arsenic contaminated water. The state of Bihar is an endemic belt for arsenic contamination in groundwater affecting over 10 million people with moderate to serious health manifestations. Life threatening disease like cancer is not uncommon now, and carcinoma type of cancer cases are on the rise. Breast cancer incidences in the state follows closely with more and more women getting affected. Approximately, 23% of the cancer types in women are related to breast cancer, diagnosed at a fairly advanced stage (III or IV) of the disease. The etiology of the disease is not clearly known though faulty lifestyle and genetic makeup cannot be ruled out. The present study attempts to derive a relation between increasing breast cancer cases with the sustained arsenic intake in the second most populated state of the country. Pathologically confirmed, female breast cancer patients (n = 55) from across the state were included in the study. Sampling of the breast tissue, blood, hair and toe nail was carried out by the surgical oncology department of the institute. As a part of cross-sectional study, (n = 12) female breast benign cases were taken as the control group and their biological samples were also collected. All the samples as per the protocol of NIOSH were digested and analysed by graphite furnace atomic absorption spectrophotometer. For the epidemiological parameter study, their age, type of malignancy, stage and demographic information was compiled. The results were correlated with the arsenic concentration in groundwater as per their endemic status and anomalous values on GIS platform. The role of geological studies to establish the morpho-stratigraphic control and aquifers with higher concentration was brought to use. The results are fairly indicative of the high correlation of anomalous concentration of arsenic with the sample population with diagnosed malignancy as compared to the control group. The maximum arsenic concentration observed in the biological samples in blood was 1856µg/L, in breast tissue 446.4µg/Kg, in hair 1296·9µg/Kg and in toenail 621·83µg/Kg respectively. The scattered plots correlate the relationship between age of the breast cancer patients with arsenic contamination, while the geospatial distribution positively correlates with the districts with increased arsenic endemicity in a predominantly alluvium dominated country. The high arsenic contamination in the biological samples of the breast cancer patients is an indicative marker to the possible relation of the disease to arsenic, as compared to the control population exposed to a much lesser toxicity. Consumption of water with more than 10 ppb arsenic contamination over a sustained longer time span has possibly exposed the population to a larger threat to disease as inferred from the findings. The disease breeding as a silent killer with reduced or unnoticeable symptoms upto a fairly advanced stage has further accentuated the problem. The present study thus endeavours to identify a significant relation of the disease with sustained intake of arsenic consumed through water and food products laden with anomalous concentration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Arsenic Induced Breast Cancer Risk in Population of Bihar, India

Kumar¹,

Ali²,

Niraj³

et al. 2021

Preprint

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“…Arsenic may also be found in vegetables, legumes, nuts and fruits. In a large cohort study of 1702 Polish women, Marciniak et al [ 57 ] found that chronic low-level exposure to arsenic compounds may lead to a 13-fold increase in breast cancer. The potential mechanism by which arsenic may influence breast cancer development includes estrogen receptor function disruption and estrogen signaling pathway suppression [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Hybrid Dietary-Blood Inflammatory Profiles and Postmenopausal Breast Cancer: A Case-Control Study

et al. 2020

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The carcinogenesis process is associated with inflammation, which can be modified by diet. There is limited evidence regarding the inflammatory status and diet in association with breast cancer (BC). The aim of this study was to investigate the association of hybrid dietary-blood inflammatory profiles (HD-BIPs) with postmenopausal breast cancer occurrence. The case-control study was conducted among 420 women (230 controls, 190 primary BC cases) aged 40–79 years from north-eastern Poland. Blood levels of C-reactive protein (CRP), interleukin-6 (IL-6) and leukocyte count were marked in 129 postmenopausal women (82 controls, 47 cases). The 62-item food frequency questionnaire (FFQ-6) was used to the dietary data collection. Two HD-BIPs were found using the Principal Component Analysis (PCA). The “Pro-healthy/Neutral-inflammatory” profile was characterized by the frequent consumption of wholemeal cereals/coarse groats, legumes, vegetables, fruits, nuts/seeds and fish. The “Unhealthy/Pro-inflammatory” profile was characterized by the frequent consumption of red/processed meats, animal fats, sugar/honey/sweets, refined cereals/fine groats, and an increased concentration of CRP, IL-6 and granulocyte-to-lymphocyte ratio. The lower odds ratio (OR) of breast cancer was associated with the higher adherence to the “Pro-healthy/Neutral-inflammatory” profile (OR = 0.38; 95% Cl: 0.18–0.80; p < 0.01 for the higher level vs. lower level, crude model; OR for one-point score increment: 0.61; 95% Cl: 0.42–0.87; p < 0.01, adjusted model). The higher OR of breast cancer was associated with the higher adherence to the “Unhealthy/Pro-inflammatory” profile (OR = 3.07; 95%Cl: 1.27–7.44; p < 0.05 for the higher level v.s. lower level, adjusted model; OR for one-point score increment: 1.18; 95%Cl: 1.02–1.36; p < 0.05, adjusted model). This study revealed that the consumption of highly processed, high in sugar and animal fat foods should be avoided because this unhealthy diet was positively associated with postmenopausal breast cancer occurrence through its pro-inflammatory potential. Instead, the frequent consumption of low-processed plant foods and fish should be recommended since this pro-healthy diet was inversely associated with the cancer occurrence even though its anti-inflammatory potential has not been confirmed in this study sample.

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“…Blood samples were taken from patients’ pre-treatment at the time of diagnosis. Total arsenic concentration in their blood was measured by the inductively coupled plasma mass spectrometer method reported in our previous study [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…Biomolecular mechanisms of As clearance are still poorly understood, however there are some theories that its biotransformation may exert carcinogenesis in both a genotoxic and non-genotoxic manner [ 15 , 16 ]. Recently we have been able to show that As is a major cancer risk factor for women in Poland–high levels of blood As (the highest quartile) is associated with more than 10-times higher risk of breast cancers as compared to quartile with the lowest As levels [ 17 ]. The above correlations have not been observed in our studies of men (data not shown).…”

Section: Introductionmentioning

confidence: 99%

Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women

et al. 2021

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In following study we examined whether blood arsenic (As) levels combined with specific polymorphisms in MT1B, GSTP1, ABCB1, NQO1, CRTC3, GPX1, SOD2, CAT, XRCC1, ERCC2 can be used as a marker for the detection of colorectal cancer (CRC) among Polish women. A retrospective case-control study of CRC included 83 CRC cases and 78 healthy controls. From each study participant pre-treatment peripheral blood was collected for As level measurement by inductively coupled–plasma mass spectrometry (ICP-MS). We estimated the odds ratio (OR) of the association between blood-As levels and CRC using multivariable unconditional logistic regression models. A low blood-As level (0.27–0.67 µg/L) was associated with an increased frequency of CRC (OR: 3.69; p = 0.005). This correlation was significantly greater when participants carried particular gene variants: CAT, rs1001179-nonCC (OR: 19.4; p = 0.001); ABCB1 rs2032582–CC (OR: 14.8; p = 0.024); GPX1 rs1050450-CC (OR: 11.6; p = 0.002) and CRTC3 rs12915189-nonGG (OR: 10.3; p = 0.003). Our study provides strong evidence that low blood-As levels are significantly associated with increased CRC occurrence and that particular gene variants significantly enhanced this correlation however, due to the novelty of these findings, we suggest further validation before a definitive statement that the combined effect of low blood-As levels with specific gene polymorphisms is a suitable CRC biomarker.

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Blood arsenic levels and the risk of familial breast cancer in Poland

Cited by 32 publications

References 47 publications

Arsenic Induced Breast Cancer Risk in Population of Bihar, India

Arsenic Induced Breast Cancer Risk in Population of Bihar, India

Hybrid Dietary-Blood Inflammatory Profiles and Postmenopausal Breast Cancer: A Case-Control Study

Low Blood-As Levels and Selected Genotypes Appears to Be Promising Biomarkers for Occurrence of Colorectal Cancer in Women

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