Blood-Based Biomarkers in Afp Normal/Stable Hepatocellular Carcinoma: Diagnostic and Prognostic Relevance of Mir-10b for Patients on Liver Transplant List

Aksoy, Fuat; Aksoy, Seçil Ak; Dündar, Halit Ziya; Tunca, Berrin; Erçelik, Melis; Tekin, Çagla; Kıyıcı, Murat; Selimoğlu, Kerem; Kaya, Ekrem

doi:10.1016/j.transproceed.2022.05.024

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…Therefore, less cumbersome methods may need to be developed before IgG oligosaccharide chains could be utilized as a clinical diagnostic marker. Moreover, it is worth noting that other methods for diagnosing HCC through serum diagnostic markers, such as exosomal DNA containing the TP53 gene mutation [32], phenylalanyl-tryptophan [33], miRNAs, such as miR-10b [34], prothrombin induced by vitamin K deficiency or antagonist-II [35], lncRNA-D16366 [36], des-gamma-carboxyprothrombin [37], and dickkopf-1 [38], etc., have been documented. However, the widespread adoption for a number of these biomarkers as a diagnostic tool has been limited, owing to low sensitivity, which is exacerbated by HCC often being found alongside chronic liver disease and inflammation [39].…”

Section: Discussionmentioning

confidence: 99%

The combination of serum oligosaccharide chain (G-test), alpha-fetoprotein, and aspartate aminotransferase to alanine aminotransferase ratio provides the optimal diagnostic value for early detection of hepatocellular carcinoma

et al. 2022

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Background The purpose of this study was to compare the diagnostic value of serum oligosaccharide chain (G-test), alpha-fetoprotein (AFP) and aspartic aminotransferase to alanine aminotransferase ratios (AAR), both alone and in combination, for predicting hepatocellular carcinoma (HCC) onset. Methods Between Januarys 2020–2022, 152 subjects admitted to the First Affiliated Hospital of Nanchang University was enrolled in this study, of which 77 had HCC, 18 chronic hepatitis (CH), 37 liver cirrhosis (LC) and 20 were healthy. Data for patient characteristics were collected, and differences between groups were analyzed by either Mann-Whitney U or χ2 tests. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic value of AFP, G-test, and AAR for HCC. Results G-test, AFP, and AAR were all found to have close correlations with HCC among the different patient groups, with G-test being the most predictive for HCC among healthy and CL patients, as represented by respective areas under the curve (AUC) of 0.953 and 0.792 (P < 0.001). By contrast, AAR had the greatest diagnostic ability for HCC among CH patients (AUC = 0.850; P < 0.001). However, the combination of all 3 biomarkers obtained the most optimal results for predicting HCC onset, in terms of predictive capability for all 3 non-HCC patient groups, yielding AUCs of 0.958, 0.898, and 0.808 (P < 0.001) for, respectively, healthy, CH, and LC patients. Additionally, AFP had higher specificity, but lower sensitivity, with increased threshold values, as the recommended threshold of AFP ≥ 400 ng/mL yielded a missed diagnosis rate of 72.7%. For AFP-negative HCC (AFP-NHCC) patients, G-test alone had the greatest diagnostic capability (AUC = 0.855; P < 0.001), sensitivity (83.8%), and specificity (87.5%). Conclusion G-test has the greatest diagnostic capability for HCC and AFP-NHCC, with high sensitivity and specificity, among healthy and LC patients. However, AAR had the highest diagnostic capability and sensitivity for HCC in CH. Overall, though, the combination of G-test, AFP and AAR provided the most optimal outcomes for predicting HCC onset, no matter the patient pre-conditions.

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Section: Discussionmentioning

confidence: 99%

The combination of serum oligosaccharide chain (G-test), alpha-fetoprotein, and aspartate aminotransferase to alanine aminotransferase ratio provides the optimal diagnostic value for early detection of hepatocellular carcinoma

et al. 2022

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“…Out of these, three miRNA (miR‐192, miR‐146, and miR‐16) were found promising diagnostic and prognostic markers (Fründt et al, 2021). Sixteen miRNAs were tested through qRT‐PCR in AFP‐stable HCC and AFP‐trending HCC patients, and it was found that upregulated miR‐24 and miR‐10b and downregulated miR‐143 had independent and significant association with HCC in AFP‐stable patients (Aksoy et al, 2022).…”

Section: Role Of Mirna In Diagnosis and Prognosismentioning

confidence: 99%

Role of miRNA in pathogenesis, diagnosis, and prognosis in hepatocellular carcinoma

Lv,

Sun

2023

Chem Biol Drug Des

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Hepatocellular carcinoma (HCC) is one of the most common cancers and is responsible for the second cancer‐related death globally. Many treatment regimens have been developed to cure the disease; however, life expectancy is still low. Therefore, there is an urgent need to explore new selective, specific, and robust diagnosis markers for efficient early recognition of the ailment. Along with the diagnosis, the treatment's effectiveness can be determined by prognostic markers, and miRNAs are excellent tools for the diagnosis and prognosis of HCC. In addition, the altered expression profile of a few miRNAs promotes HCC cell migration and invasion, and selective up‐ or downregulation of these responsible genes may help mitigate the disorder. On one hand, few of the miRNAs have been found to enhance angiogenesis, a crucial step of tumor growth; on the other hand, upregulation of specific miRNAs is reported to suppress angiogenesis and resulting tumor growth of HCC cells. Exosomal miRNAs have significant implications in promoting angiogenesis, increased endothelial cell permeability, tube formation, and metastasis to hepatic and pulmonary tissues. miRNA also attributes to drug resistance toward chemotherapy and the prevention of autophagy also. Identifying novel miRNA and determining their differential expression in HCC tissue may serve as a potential tool for diagnosis, prognosis, and therapy to enhance the life expectancy and quality of life of HCC patients. In the present review, we have summarized the recent advances in HCC‐related research.

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“…21 Because of their regulated formation and cell-targeting specificity, they could serve not only as noninvasive diagnostic biomarkers but also as potential therapeutic nanocarriers. 22,23 Qiu et al analyzed the association of exosomal micro ribonucleic acids (microRNAs) with viral hepatitis B virus (HBV) reactivation after LT. In a pilot cohort of patients with and without HBV reactivation, they identified exosomal microRNA-766 as a promising prognostic biomarker and a potential functional target for the treatment of HBV reactivation.…”

Section: Novel Biomarkersmentioning

confidence: 99%

“…In a pilot cohort of patients with and without HBV reactivation, they identified exosomal microRNA-766 as a promising prognostic biomarker and a potential functional target for the treatment of HBV reactivation. 23,24 Further exploring the role of novel, innovative circulatory biomarkers, Izzy et al determined that symmetric dimethylarginine, as a marker of endothelial injury, may predict future renal failure in LT recipients. 25 Glycomic signatures, a comprehensive analysis of glycans in a specific biological setting, is an emerging tool in the identification of prognostic biomarkers.…”

Section: Novel Biomarkersmentioning

confidence: 99%

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2020–2021?—Report of the Basic and Translational Research Committee of the International Liver Transplantation Society

et al. 2021

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Blood-Based Biomarkers in Afp Normal/Stable Hepatocellular Carcinoma: Diagnostic and Prognostic Relevance of Mir-10b for Patients on Liver Transplant List

Cited by 7 publications

References 33 publications

The combination of serum oligosaccharide chain (G-test), alpha-fetoprotein, and aspartate aminotransferase to alanine aminotransferase ratio provides the optimal diagnostic value for early detection of hepatocellular carcinoma

The combination of serum oligosaccharide chain (G-test), alpha-fetoprotein, and aspartate aminotransferase to alanine aminotransferase ratio provides the optimal diagnostic value for early detection of hepatocellular carcinoma

Role of miRNA in pathogenesis, diagnosis, and prognosis in hepatocellular carcinoma

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2020–2021?—Report of the Basic and Translational Research Committee of the International Liver Transplantation Society

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