Blood biochemical indicators in young and adult <i>Cebus apella</i> of both sexes

Núñez, Harold; Araya, Magdalena; Cisternas, Felipe A.; Arredondo, Miguel; Méndez, Marco A.; Pizarro, Fernando; Ortiz, A; Ortíz, Rita; Olivares, Manuel

doi:10.1111/j.1600-0684.2007.00215.x

Cited by 10 publications

(15 citation statements)

References 14 publications

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“…Results were first compared to values previously obtained in the reference group (25). At 36 mo, Fe nutrition indicators, liver enzymes, and serum metal concentrations were for all four groups within the range measured in the colony ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Their diets consisted of fresh foods plus vitamin and mineral supplements following the norms of the Primate Center, as previously published (25). Copper dosing was set at 5.5 mg and 7.5 mg/d (as copper gluconate) in 1 or 2 doses to avoid acute manifestations (mainly salivation and loose stools).…”

Section: Methodsmentioning

confidence: 99%

“…Food and water were consumed ad libitum (25). Monkeys that showed normal clinical and blood biochemical values were randomly assigned to one of four groups (4 animals each): adult (3-3.5 y at enrollment) monkeys treated with copper gluconate for 36 mo (ACu 6 ; 2 females, 2 males), age-matched controls (AC; 1 female, 3 male adult controls, matched by age, no copper treatment); young (newborn at enrollment) monkeys treated with copper for 36 mo (YCu; 2 female, 2 males), and young age-matched controls (YC; 2 female, 2 males) fed the same formula without copper.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, a hair sample was obtained from the monkey's flank and kept at room temperature until analyzed. Hematological indicators, liver aminotransferases (serum aspartate aminotransferase, alanine aminotransferase, and GGT), and serum and hair copper concentrations were measured as previously described (25).…”

Section: Methodsmentioning

confidence: 99%

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Administration of High Doses of Copper to Capuchin Monkeys Does Not Cause Liver Damage but Induces Transcriptional Activation of Hepatic Proliferative Responses

Araya

Núñez

Pavéz

et al. 2012

The Journal of Nutrition

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Liver cells respond to copper loading upregulating protective mechanisms. However, to date, except for liver content, there are no good indicators that identify individuals with excess liver copper. We hypothesized that administering high doses of copper to young (5.5 mg Cu · kg⁻¹ . d⁻¹) and adult (7.5 mg Cu · kg⁻¹ . d⁻¹) capuchin monkeys would induce detectable liver damage. Study groups included adult monkeys (2 females, 2 males) 3-3.5 y old at enrollment treated with copper for 36 mo (ACu); age-matched controls (1 female, 3 males) that did not receive additional copper (AC); young monkeys (2 female, 2 males) treated from birth with copper for 36 mo (YCu); and young age-matched controls (2 female, 2 males) that did not receive additional copper (YC). We periodically assessed clinical, blood biochemical, and liver histological indicators and at 36 mo the hepatic mRNA abundance of MT2a, APP, DMT1, CTR1, HGF, TGFβ, and NFκΒ only in adult monkeys. After 36 mo, the liver copper concentration was 4-5 times greater in treated monkeys relative to controls. All monkeys remained healthy with normal routine serum biochemical indices and there was no evidence of liver tissue damage. Relative mRNA abundance of HGF, TGFβ and NFκB was significantly greater in ACu than in AC monkeys. In conclusion, capuchin monkeys exposed to copper at doses up to 50 times the current upper level enhanced expression of genes related to inflammation and injury without clinical, blood biochemical, or histological evidence of liver damage.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Administration of High Doses of Copper to Capuchin Monkeys Does Not Cause Liver Damage but Induces Transcriptional Activation of Hepatic Proliferative Responses

Araya

Núñez

Pavéz

et al. 2012

The Journal of Nutrition

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“…O valor médio de glicose observada em machos , porém próximos ao valores encontrados por outros autores 13,17 .…”

Section: Dosagens Bioquímicasunclassified

Perfil bioquímico de Sapajus libidinosus spix, 1923, e bugios (Alouatta caraya Humboldt, 1812) de vida livre do Sul do Estado do Tocantins

Ribeiro

Silva-Júnior

Lemes

et al. 2016

EST

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Resumo: Este estudo objetivou estabelecer valores de referência para dosagens de parâmetros sanguíneos de macaco-prego (Sapajus libidinosus) e bugios (Alouatta caraya) de vida livre no Sul do estado do Tocantins, Brasil. Foram colhidas amostras de sangue de 15 macacos-prego e 47 bugios pretos, todos capturados manualmente durante o resgate de fauna da usina hidrelétrica São Salvador situada ao sul do Estado do Tocantins, no alto rio Tocantins. Foram avaliadas variáveis distribuídas nos seguintes grupos: dosagens bioquímicas (dez variáveis), lipídicas (cinco variáveis) e hormonais (duas variáveis). Os resultados obtidos para cada variável foram apresentados e comparados por sexo usando estatística descritiva considerando os valores mínimos, máximos, média e desvio padrão. Para S. libidinosus foi observada diferenças significativas em apenas três variáveis (Peso corporal, creatinina e hormônio T3), houve diferença sexual significativa em apenas um grupo de variáveis (hormônios), enquanto que para A. caraya foi observada diferença significativa em oito variáveis (peso corporal, VLDL, triglicérides, proteínas totais, RDW, plaquetas, DHL e fosfatase alcalina), apenas o grupo de variáveis relacionado à bioquímica geral apresentou diferença sexual significativa. A importância deste trabalho científico deve-se ao seu caráter inédito relacionado à avaliação e variação sexual do perfil bioquímico de Sapajus libidinosus e Alouatta caraya de vida livre. Palavras-chave: Alouatta caraya. Dosagens bioquímicas. Sapajus libidinosus.

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Hematology and Serum Biochemistry in Wild Howler Monkeys

Canales‐Espinosa¹,

Rovirosa-Hernández²,

Thoisy³

et al. 2014

Howler Monkeys

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Blood biochemical indicators in young and adult Cebus apella of both sexes

Abstract: These results provide valuable information that help understanding the physiology of C. apella.

Cited by 10 publications

References 14 publications

Administration of High Doses of Copper to Capuchin Monkeys Does Not Cause Liver Damage but Induces Transcriptional Activation of Hepatic Proliferative Responses

Administration of High Doses of Copper to Capuchin Monkeys Does Not Cause Liver Damage but Induces Transcriptional Activation of Hepatic Proliferative Responses

Perfil bioquímico de Sapajus libidinosus spix, 1923, e bugios (Alouatta caraya Humboldt, 1812) de vida livre do Sul do Estado do Tocantins

Hematology and Serum Biochemistry in Wild Howler Monkeys

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