Blood biomarkers for sarcopenia: A systematic review and meta-analysis of diagnostic test accuracy studies

Lian, Rongna; Liu, Qianqian; Jiang, Gengchen; Zhang, Xiangyu; Tang, Huiyu; Lu, Jing; Yang, Ming

doi:10.1016/j.arr.2023.102148

Cited by 9 publications

(5 citation statements)

References 55 publications

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“…Biomarkers are of tremendous importance for the prediction, diagnosis, and observation of the therapeutic success of common complex and multifactorial diseases. However, the common methods of clinical biochemistry are ineffective or have low efficacy for diagnosing senile diseases at early stages [28,57]. The predictive power of the traditional biomarkers used (e.g., plasma metabolites and body parameters) is apparently not sufficient for the reliable monitoring of stage-dependent pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments

Goncharov,

Popova,

Kudryavtsev

et al. 2024

IJMS

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The process of aging is accompanied by a dynamic restructuring of the immune response, a phenomenon known as immunosenescence. Further, damage to the endothelium can be both a cause and a consequence of many diseases, especially in elderly people. The purpose of this study was to carry out immunological and biochemical profiling of elderly people with acute ischemic stroke (AIS), chronic cerebral circulation insufficiency (CCCI), prediabetes or newly diagnosed type II diabetes mellitus (DM), and subcortical ischemic vascular dementia (SIVD). Socio-demographic, lifestyle, and cognitive data were obtained. Biochemical, hematological, and immunological analyses were carried out, and extracellular vesicles (EVs) with endothelial CD markers were assessed. The greatest number of significant deviations from conditionally healthy donors (HDs) of the same age were registered in the SIVD group, a total of 20, of which 12 were specific and six were non-specific but with maximal differences (as compared to the other three groups) from the HDs group. The non-specific deviations were for the MOCA (Montreal Cognitive Impairment Scale), the MMSE (Mini Mental State Examination) and life satisfaction self-assessment scores, a decrease of albumin levels, and ADAMTS13 (a Disintegrin and Metalloproteinase with a Thrombospondin Type 1 motif, member 13) activity, and an increase of the VWF (von Willebrand factor) level. Considering the significant changes in immunological parameters (mostly Th17-like cells) and endothelial CD markers (CD144 and CD34), vascular repair was impaired to the greatest extent in the DM group. The AIS patients showed 12 significant deviations from the HD controls, including three specific to this group. These were high NEFAs (non-esterified fatty acids) and CD31 and CD147 markers of EVs. The lowest number of deviations were registered in the CCCI group, nine in total. There were significant changes from the HD controls with no specifics to this group, and just one non-specific with a maximal difference from the control parameters, which was α1-AGP (alpha 1 acid glycoprotein, orosomucoid). Besides the DM patients, impairments of vascular repair were also registered in the CCCI and AIS patients, with a complete absence of such in patients with dementia (SIVD group). On the other hand, microvascular damage seemed to be maximal in the latter group, considering the biochemical indicators VWF and ADAMTS13. In the DM patients, a maximum immune response was registered, mainly with Th17-like cells. In the CCCI group, the reaction was not as pronounced compared to other groups of patients, which may indicate the initial stages and/or compensatory nature of organic changes (remodeling). At the same time, immunological and biochemical deviations in SIVD patients indicated a persistent remodeling in microvessels, chronic inflammation, and a significant decrease in the anabolic function of the liver and other tissues. The data obtained support two interrelated assumptions. Taking into account the primary biochemical factors that trigger the pathological processes associated with vascular pathology and related diseases, the first assumption is that purine degradation in skeletal muscle may be a major factor in the production of uric acid, followed by its production by non-muscle cells, the main of which are endothelial cells. Another assumption is that therapeutic factors that increase the levels of endothelial progenitor cells may have a therapeutic effect in reducing the risk of cerebrovascular disease and related neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 99%

Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments

Goncharov,

Popova,

Kudryavtsev

et al. 2024

IJMS

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“…The demographic affected by sarcopenia often presents a clinical convergence with individuals experiencing frailty, as the symptomatic criteria for diagnosing both conditions bear resemblance, particularly with sarcopenia aligning closely with the subtype of frailty known as physical frailty ( Kondoh and Kameda, 2023 ). A recent systematic review and meta-analysis undertook a comprehensive exploration of presently reported potential blood biomarkers associated with sarcopenia ( Lian et al, 2023 ). Despite the breadth of this review, the incorporated studies exhibited notable divergences due to disparities in research designs, leading to the revelation that the thirteen scrutinized biomarkers held low diagnostic efficacy for screening sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the breadth of this review, the incorporated studies exhibited notable divergences due to disparities in research designs, leading to the revelation that the thirteen scrutinized biomarkers held low diagnostic efficacy for screening sarcopenia. This underscores the importance of alternative methodologies, such as Mendelian randomization, which, unencumbered by confounding factors in observational studies, presents a promising avenue for the exploration and validation of novel biomarkers in this specific context ( Lian et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…The investigation of metabolic biomarkers holds significant potential in elucidating the molecular underpinnings of aging-related diseases, thereby aiding in the development of preventative strategies. For instance, the current diagnostic approach for sarcopenia predominantly relies on sophisticated and equipment-intensive methods, such as computed tomography (CT), to assess muscle mass and function, which is not only costly but also often inaccessible to many patients, suggesting the identification of blood-based biomarkers for the screening and diagnosis of sarcopenia presents a more straightforward and cost-effective alternative ( Lian et al, 2023 ). However, the challenge remains that no biomarker has yet been conclusively identified for the specific diagnosis of conditions such as frailty, sarcopenia, and vascular aging-related traits and diseases.…”

Section: Introductionmentioning

confidence: 99%

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Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases

Qian,

Huang,

Zhang

et al. 2024

Front. Genet.

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Background: Physical weakness and cardiovascular risk increase significantly with age, but the underlying biological mechanisms remain largely unknown. This study aims to reveal the causal effect of circulating metabolites on frailty, sarcopenia and vascular aging related traits and diseases through a two-sample Mendelian Randomization (MR) analysis.Methods: Exposures were 486 metabolites analyzed in a genome-wide association study (GWAS), while outcomes included frailty, sarcopenia, arterial stiffness, atherosclerosis, peripheral vascular disease (PAD) and aortic aneurysm. Primary causal estimates were calculated using the inverse-variance weighted (IVW) method. Methods including MR Egger, weighted median, Q-test, and leave-one-out analysis were used for the sensitive analysis.Results: A total of 125 suggestive causative associations between metabolites and outcomes were identified. Seven strong causal links were ultimately identified between six metabolites (kynurenine, pentadecanoate (15:0), 1-arachidonoylglycerophosphocholine, androsterone sulfate, glycine and mannose) and three diseases (sarcopenia, PAD and atherosclerosis). Besides, metabolic pathway analysis identified 13 significant metabolic pathways in 6 age-related diseases. Furthermore, the metabolite-gene interaction networks were constructed.Conclusion: Our research suggested new evidence of the relationship between identified metabolites and 6 age-related diseases, which may hold promise as valuable biomarkers.

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“…The underlying pathogenesis of sarcopenia remains unknown. Since dysregulated inflammatory response has been frequently reported to be associated to the reduction in muscle mass and physical function in adults with sarcopenia, inflammatory biomarkers may be used to understand the pathogenesis of sarcopenia, and provide early diagnosis and prognosis prediction [ 12 – 14 ]. For example, a number of pro-inflammatory cytokines have been proposed to decrease muscle mass by increasing muscle protein breakdown, and reduce muscle protein synthesis, leading to sarcopenia [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Association between the systemic immune-inflammation index and sarcopenia: a systematic review and meta-analysis

Xie,

2024

J Orthop Surg Res

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Background Sarcopenia is associated with increased morbidity and mortality. The systemic immune-inflammation index (SII) has been correlated to a variety of disorders. The present study conducted a systematic review and meta-analysis to investigate the relationship between SII and sarcopenia. Methods A literature search was performed in Web of Science, PubMed, Embase, Cochrane Library, CINAHL, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database, and VIP Chinese Science and Technology Database, from inception to March 2024. Then, the literature quality was assessed. After the heterogeneity test, a random effects or fixed effects model was applied to establish the forest plot, and investigate the relationship between SII and sarcopenia. Then, the sensitivity analysis and publication bias were examined. Results Nine articles, which included 18,634 adults, were analyzed. Sarcopenic adults had higher SII levels, when compared to non-sarcopenic adults (standardized mean difference [SMD] = 0.66, 95% confidence interval [CI] = 0.22 − 0.19, p = 0.003). The high SII level was associated to the increased risk of sarcopenia (odds ratio = 1.52, 95% CI = 1.09–2.13, p = 0.01). In addition, the subgroup analysis revealed that the SII levels were higher in the sarcopenic group, when compared to the non-sarcopenic group, in elderly adults, as well as in adults with or without gastrointestinal disorders. The analysis was robust with a low risk of publication bias. Conclusions SII is closely associated to sarcopenia. Sarcopenic adults had elevated SII levels. The high SII level increased the risk of sarcopenia. Large scale multi-center prospective studies are required to validate these study findings.

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Blood biomarkers for sarcopenia: A systematic review and meta-analysis of diagnostic test accuracy studies

Cited by 9 publications

References 55 publications

Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments

Immunological Profile and Markers of Endothelial Dysfunction in Elderly Patients with Cognitive Impairments

Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases

Association between the systemic immune-inflammation index and sarcopenia: a systematic review and meta-analysis

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