2021
DOI: 10.3390/life11020135
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Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke

Abstract: Stroke is a major cause of disability and death globally, and prediction of mortality represents a crucial challenge. We aimed to identify blood biomarkers measured during acute ischemic stroke that could predict long-term mortality. Nine hundred and forty-one ischemic stroke patients were prospectively recruited in the Stroke-Chip study. Post-stroke mortality was evaluated during a median 4.8-year follow-up. A 14-biomarker panel was analyzed by immunoassays in blood samples obtained at hospital admission. Bio… Show more

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Cited by 11 publications
(16 citation statements)
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“…Indeed, all these circulating inflammatory markers have been associated with poor outcome after AIS. [37][38][39][40][41][42][43] Especially, IL-6 seems to play a pivotal role in thromboinflammation and has been associated with futile reperfusion in AIS. 18,44 A growing number of evidence suggest that elevated levels of systemic inflammatory markers are associated with small vessel disease burden and progression.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Indeed, all these circulating inflammatory markers have been associated with poor outcome after AIS. [37][38][39][40][41][42][43] Especially, IL-6 seems to play a pivotal role in thromboinflammation and has been associated with futile reperfusion in AIS. 18,44 A growing number of evidence suggest that elevated levels of systemic inflammatory markers are associated with small vessel disease burden and progression.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, all these circulating inflammatory markers have been associated with poor outcome after AIS. 37–43 Especially, IL-6 seems to play a pivotal role in thromboinflammation and has been associated with futile reperfusion in AIS. 18,44…”
Section: Discussionmentioning
confidence: 99%
“…Another study including 937 acute ischemic stroke patients investigated the levels of 14 blood biomarkers and found that combined evaluation of increased endostatin, tumour necrosis factor receptor‐1, and IL‐6 levels was able to predict increased risk of death post‐stroke. Mortality risk increased up to 70% when these three biomarkers were elevated, compared to 10% when the levels of the aforementioned biomarkers were normal (Ramiro et al, 2021).…”
Section: Integration Of Different Modalities and Future Directionsmentioning
confidence: 99%
“…Although ischemic stroke is the major type of these cases [ 2 , 3 ], the various etiology and clinical progress of cerebral ischemia make it difficult to predict stroke prognostication [ [4] , [5] , [6] ], highlighting the need for more sensitive predictive tools and biomarkers [ [7] , [8] , [9] ]. Previous studies have emphasized the potential of blood biomarkers in predicting functional outcomes and mortality after stroke [ [10] , [11] , [12] , [13] ].…”
Section: Introductionmentioning
confidence: 99%