Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity

Gerber, Alan; Esnault, Cyril; Aubert, Grégory; Treisman, Richard; Pralong, François P.; Schibler, Ueli

doi:10.1016/j.cell.2012.12.027

Cited by 150 publications

(166 citation statements)

References 51 publications

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“…grown under continuous light, compared to cultures in which the cells are synchronized and measured at specific time points in the cycle (W.F.M., unpublished data). This phenomenon has been shown to extend to mammalian cells, where the circadian clock drives periodic changes in actin dynamics (Gerber et al, 2013) and Golgi organization (Muueller and Gerber, 1985).…”

Section: Temporal Heterogeneity Resulting From the Circadian Cyclementioning

confidence: 99%

Organelles – understanding noise and heterogeneity in cell biology at an intermediate scale

Chang

Marshall

2017

Journal of Cell Science

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Many studies over the years have shown that non-genetic mechanisms for producing cell-to-cell variation can lead to highly variable behaviors across genetically identical populations of cells. Most work to date has focused on gene expression noise as the primary source of phenotypic heterogeneity, yet other sources may also contribute. In this Commentary, we explore organelle-level heterogeneity as a potential secondary source of cellular 'noise' that contributes to phenotypic heterogeneity. We explore mechanisms for generating organelle heterogeneity and present evidence of functional links between organelle morphology and cellular behavior. Given the many instances in which molecular-level heterogeneity has been linked to phenotypic heterogeneity, we posit that organelle heterogeneity may similarly contribute to overall phenotypic heterogeneity and underline the importance of studying organelle heterogeneity to develop a more comprehensive understanding of phenotypic heterogeneity. Finally, we conclude with a discussion of the medical challenges associated with phenotypic heterogeneity and outline how improved methods for characterizing and controlling this heterogeneity may lead to improved therapeutic strategies and outcomes for patients.

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Section: Temporal Heterogeneity Resulting From the Circadian Cyclementioning

confidence: 99%

Organelles – understanding noise and heterogeneity in cell biology at an intermediate scale

Chang

Marshall

2017

Journal of Cell Science

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“…S7D). We have shown elsewhere that systemic circadian activation of SRF target genes in the liver is associated with circadian fluctuations in MRTF activity (Gerber et al 2013).…”

Section: Both Mrtf-and Tcf-linked Signaling To Srf Can Resynchronize mentioning

confidence: 99%

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

Esnault¹,

Stewart

Gualdrini³

et al. 2014

Genes Dev.

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323

417

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The transcription factor SRF (serum response factor) recruits two families of coactivators, the MRTFs (myocardinrelated transcription factors) and the TCFs (ternary complex factors), to couple gene transcription to growth factor signaling. Here we investigated the role of the SRF network in the immediate transcriptional response of fibroblasts to serum stimulation. SRF recruited its cofactors in a gene-specific manner, and virtually all MRTF binding was directed by SRF. Much of SRF DNA binding was serum-inducible, reflecting a requirement for MRTF-SRF complex formation in nucleosome displacement. We identified 960 serum-responsive SRF target genes, which were mostly MRTF-controlled, as assessed by MRTF chromatin immunoprecipitation (ChIP) combined with deep sequencing (ChIP-seq) and/or sensitivity to MRTF-linked signals. MRTF activation facilitates RNA polymerase II (Pol II) recruitment or promoter escape according to gene context. MRTF targets encode regulators of the cytoskeleton, transcription, and cell growth, underpinning the role of SRF in cytoskeletal dynamics and mechanosensing. Finally, we show that specific activation of either MRTFs or TCFs can reset the circadian clock.

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“…Further studies are needed to evaluate the temporal order and relative contributions of these and other metabolic hormones in mediating feeding-associated resetting of circadian transcriptional programs in peripheral tissues. Along this line, using a novel screening approach, Gerber and coworkers identified serum response factor (SRF) as an immediate early response transcription factor in the liver relaying signals from as yet unidentified oscillating blood-borne factors to control liver clock gene expression (Gerber et al 2013).…”

Section: Metabolic Hormone Circadian Clock Feedbackmentioning

confidence: 99%

Endocrine regulation of circadian physiology

Tsang

Astiz

Friedrichs

et al. 2016

Journal of Endocrinology

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Endogenous circadian clocks regulate 24-h rhythms of behavior and physiology to align with external time. The endocrine system serves as a major clock output to regulate various biological processes. Recent findings suggest that some of the rhythmic hormones can also provide feedback to the circadian system at various levels, thus contributing to maintaining the robustness of endogenous rhythmicity. This delicate balance of clock-hormone interaction is vulnerable to modern lifestyle factors such as shiftwork or high-calorie diets, altering physiological set points. In this review, we summarize the current knowledge on the communication between the circadian timing and endocrine systems, with a focus on adrenal glucocorticoids and metabolic peptide hormones. We explore the potential role of hormones as systemic feedback signals to adjust clock function and their relevance for the maintenance of physiological and metabolic circadian homeostasis.

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Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity

Cited by 150 publications

References 51 publications

Organelles – understanding noise and heterogeneity in cell biology at an intermediate scale

Organelles – understanding noise and heterogeneity in cell biology at an intermediate scale

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

Endocrine regulation of circadian physiology

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